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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2458
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a1
Name: cytochrome P450, family 1, subfamily a, polypeptide 1
Acc ID: CHEBI:28145
Term: dibenzofuran
Definition: A mancude organic heterotricyclic parent that consists of a furan ring flanked by two benzene rings ortho-fused across the 2,3- and 4,5-positions.
Chemical ID: MESH:C023614
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a1increases expressionEXP 6480464CTDdibenzofuran analog results in increased expression of CYP1A1 mRNA; dibenzofuran analog results in increased expression of CYP1A1 proteinPMID:20566336
Cyp1a1multiple interactionsEXP 6480464CTD2,2',4,4',5-brominated diphenyl ether inhibits the reaction [dibenzofuran analog results in increased expression of CYP1A1 mRNA]; 2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [dibenzofuran analog results in increased expression of CYP1A1 mRNA]; 2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [dibenzofuran analog results in increased expression of CYP1A1 protein]PMID:20566336
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