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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2458
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a1
Name: cytochrome P450, family 1, subfamily a, polypeptide 1
Acc ID: CHEBI:33007
Term: chromium(6+)
Definition: A monoatomic hexacation that has formula Cr.
Chemical ID: MESH:C074702
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a1affects expressionISOCyp1a1 (Mus musculus)6480464CTDchromium hexavalent ion affects the expression of CYP1A1 mRNAPMID:28472532
Cyp1a1increases expressionISOCyp1a1 (Mus musculus)6480464CTDchromium hexavalent ion results in increased expression of CYP1A1 mRNAPMID:16517059
Cyp1a1multiple interactionsISOCyp1a1 (Mus musculus)6480464CTD[chromium hexavalent ion co-treated with Benzo(a)pyrene] affects the expression of CYP1A1 mRNA; [chromium hexavalent ion co-treated with Benzo(a)pyrene] results in increased expression of CYP1A1 protein; Ascorbic Acid inhibits the reaction [chromium hexavalent ion results in increased expression of CYP1A1 mRNA]PMID:16517059 PMID:25820237
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