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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2458
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a1
Name: cytochrome P450, family 1, subfamily a, polypeptide 1
Acc ID: CHEBI:34873
Term: N-nitrosodiethylamine
Definition: A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
Chemical ID: MESH:D004052
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a1increases expressionEXP 6480464CTDDiethylnitrosamine results in increased expression of CYP1A1 mRNA; Diethylnitrosamine results in increased expression of CYP1A1 proteinPMID:21295105 PMID:23494807 PMID:27565560
Cyp1a1multiple interactionsEXP 6480464CTD[Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased expression of CYP1A1 protein; [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CYP1A1 mRNA; [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CYP1A1 protein; [Diethylnitrosamine co-treated with oxfendazole co-treated with isoquercitrin] results in increased expression of CYP1A1 mRNA; [Diethylnitrosamine co-treated with oxfendazole] results in increased expression of CYP1A1 mRNA; [Diethylnitrosamine co-treated with Piperonyl Butoxide] results in increased expression of CYP1A1 mRNA; [indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in increased expression of CYP1A1 mRNA; [indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of CYP1A1 mRNA; [Mastic Resin co-treated with Diethylnitrosamine] results in increased expression of CYP1A1 mRNA; [Omeprazole co-treated with Diethylnitrosamine] results in increased expression of CYP1A1 mRNA; [Orphenadrine co-treated with Diethylnitrosamine] results in increased expression of CYP1A1 mRNA; [oxfendazole co-treated with Diethylnitrosamine] results in increased expression of CYP1A1 mRNA; [oxfendazole co-treated with Diethylnitrosamine] results in increased expression of CYP1A1 protein; allyl sulfide inhibits the reaction [Diethylnitrosamine results in increased expression of CYP1A1 mRNA]; beta-Naphthoflavone promotes the reaction [Diethylnitrosamine results in increased expression of CYP1A1 mRNA]; Diethylnitrosamine results in increased expression of and results in increased activity of CYP1A1 protein; Melatonin inhibits the reaction [[Diethylnitrosamine co-treated with oxfendazole] results in increased expression of CYP1A1 mRNA]PMID:11165752 PMID:18164116 PMID:18648771 PMID:18754104 PMID:18977376 PMID:20033131 PMID:20045035 PMID:21295105 PMID:22129741 PMID:22687989 PMID:23494807 PMID:23665939
Cyp1a1multiple interactionsISOCyp1a1 (Mus musculus)6480464CTD2,4,5,2',4',5'-hexachlorobiphenyl promotes the reaction [[3,4,5,3',4'-pentachlorobiphenyl co-treated with Diethylnitrosamine] results in increased expression of CYP1A1 mRNA]; [3,4,5,3',4'-pentachlorobiphenyl co-treated with Diethylnitrosamine] results in increased expression of CYP1A1 mRNA; [[dicyclanil co-treated with Diethylnitrosamine] results in increased expression of CYP1A1 mRNA] which results in increased abundance of Reactive Oxygen Species; [dicyclanil co-treated with Diethylnitrosamine] results in increased expression of CYP1A1 mRNA; [Diethylnitrosamine co-treated with Piperonyl Butoxide] results in increased expression of CYP1A1 mRNA; Diethylnitrosamine promotes the reaction [AHR protein binds to CYP1A1 promoter]; Plant Extracts inhibits the reaction [[[dicyclanil co-treated with Diethylnitrosamine] results in increased expression of CYP1A1 mRNA] which results in increased abundance of Reactive Oxygen Species]; Plant Extracts inhibits the reaction [[Diethylnitrosamine co-treated with dicyclanil] results in increased expression of CYP1A1 mRNA]PMID:15535986 PMID:17162532 PMID:19182440 PMID:19690152 PMID:20101389 PMID:20118626 PMID:23457121
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