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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2458
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a1
Name: cytochrome P450, family 1, subfamily a, polypeptide 1
Acc ID: CHEBI:5692
Term: hexachlorobenzene
Definition: A member of the class of chlorobenzenes that is benzene in which all of the hydrogens are replaced by chlorines. An agricultural fungicide introduced in the mid-1940s and formerly used as a seed treatment, its use has been banned since 1984 under the Stockholm Convention on Persistent Organic Pollutants.
Chemical ID: MESH:D006581
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a1increases expressionEXP 6480464CTDHexachlorobenzene results in increased expression of CYP1A1 mRNA; Hexachlorobenzene results in increased expression of CYP1A1 proteinPMID:15159207 PMID:17202759 PMID:2539049 PMID:2845946 PMID:2856071
Cyp1a1increases expressionISOCyp1a1 (Mus musculus)6480464CTDHexachlorobenzene results in increased expression of CYP1A1 mRNAPMID:28923513 PMID:37169060
Cyp1a1increases expressionISOCYP1A1 (Homo sapiens)6480464CTDHexachlorobenzene results in increased expression of CYP1A1 mRNAPMID:19879930 PMID:27519288
Cyp1a1multiple interactionsISOCyp1a1 (Mus musculus)6480464CTDHexachlorobenzene affects the reaction [AHR protein affects the expression of CYP1A1 mRNA]PMID:28923513
Cyp1a1multiple interactionsISOCYP1A1 (Homo sapiens)6480464CTDHexachlorobenzene results in increased expression of and results in increased activity of CYP1A1 proteinPMID:24365113
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