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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2458
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a1
Name: cytochrome P450, family 1, subfamily a, polypeptide 1
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a1decreases expressionEXP 6480464CTDDoxorubicin results in decreased expression of CYP1A1 mRNAPMID:32289291
Cyp1a1increases expressionEXP 6480464CTDDoxorubicin results in increased expression of CYP1A1 mRNA; Doxorubicin results in increased expression of CYP1A1 proteinPMID:19796650
Cyp1a1multiple interactionsEXP 6480464CTDDoxorubicin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]PMID:18493746
Cyp1a1decreases expressionISOCyp1a1 (Mus musculus)6480464CTDDoxorubicin results in decreased expression of CYP1A1 mRNAPMID:21040762
Cyp1a1increases expressionISOCyp1a1 (Mus musculus)6480464CTDDoxorubicin results in increased expression of CYP1A1 mRNAPMID:22712078
Cyp1a1multiple interactionsISOCyp1a1 (Mus musculus)6480464CTD[[MT1 protein co-treated with MT2 protein] affects the susceptibility to Doxorubicin] which affects the expression of CYP1A1 mRNA; Lovastatin inhibits the reaction [Doxorubicin results in increased expression of CYP1A1 mRNA]PMID:21040762 PMID:22712078
Cyp1a1multiple interactionsISOCYP1A1 (Homo sapiens)6480464CTDDoxorubicin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]PMID:18493746
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