RGD Reference Report - Effect of CYP1A1 MspI polymorphism on cigarette smoking related coronary artery disease and diabetes. - Rat Genome Database

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Effect of CYP1A1 MspI polymorphism on cigarette smoking related coronary artery disease and diabetes.

Authors: Wang, XL  Greco, M  Sim, AS  Duarte, N  Wang, J  Wilcken, DE 
Citation: Wang XL, etal., Atherosclerosis. 2002 Jun;162(2):391-7.
RGD ID: 2307073
Pubmed: PMID:11996959   (View Abstract at PubMed)

CYP1A1, is one of the key detoxifying enzymes catabolizing cigarette smoking derived toxins and may be relevant to smoking-induced atherogenesis. Recently a CYP1A1 MspI polymorphism at the 3'-flanking region of the gene has been found to be associated with smoking related cancer risk and may, therefore, also be associated with vascular disease. To explore this, we investigated interactive effects between smoking and the CYP1A1 MspI polymorphism on coronary artery disease (CAD), diabetes and hypertension in 701 patients (aged < or =65 years) consecutively referred to Eastern Heart Clinic for angiographic investigation. The frequencies of the TT (80.2%), TC (17.7%) and CC (2.1%) genotypes were in Hardy-Weinberg equilibrium with the rare C allele frequency 0.11. The C allele carriers had an increased risk for triple vessel disease (three major epicardial coronary arteries with > or =50% luminal obstruction, OR, 3.44; 95%CI, 1.46-8.09; P=0.0046) in light smokers (< or =20 packyears). We further identified an interactive effect between smoking, the CYP1A1 MspI polymorphism and type 2 diabetes (chi(2)=9.508, P=0.002). The C allele carriers who were smokers had an increased risk of diabetes (OR, 2.44; 95%CI, 1.32-4.49; P=0.0059). Our study suggests that CYP1A1 may participate in the pathogenesis of atherosclerosis and in the development of diabetes and its vascular complications. The presence of the rare C allele of the CYP1A1 gene in smokers may enhance predisposition to severe CAD and type 2 diabetes. These findings contribute to the understanding of cardiovascular risk and to smoking related vascular disease.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
diabetes mellitus  IAGP 2307073associated with Smoking Inhalation Injury and DNA:polymorphism:3' UTR:5639T>C (human)RGD 
diabetes mellitus  ISOCYP1A1 (Homo sapiens)2307073; 2307073associated with Smoking Inhalation Injury and DNA:polymorphism:3' UTR:5639T>C (human)RGD 
type 2 diabetes mellitus  IAGP 2307073DNA:polymorphism:3' UTR:5639T>C (human)RGD 
type 2 diabetes mellitus  ISOCYP1A1 (Homo sapiens)2307073; 2307073DNA:polymorphism:3' UTR:5639T>C (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cyp1a1  (cytochrome P450, family 1, subfamily a, polypeptide 1)

Genes (Mus musculus)
Cyp1a1  (cytochrome P450, family 1, subfamily a, polypeptide 1)

Genes (Homo sapiens)
CYP1A1  (cytochrome P450 family 1 subfamily A member 1)


Additional Information