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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2458
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a1
Name: cytochrome P450, family 1, subfamily a, polypeptide 1
Acc ID: CHEBI:25812
Term: ozone
Definition: An elemental molecule with formula O3. An explosive, pale blue gas (b.p. -112degreeC) that has a characteristic, pungent odour, it is continuously produced in the upper atmosphere by the action of solar ultraviolet radiation on atmospheric oxygen. It is an antimicrobial agent used in the production of bottled water, as well as in the treatment of meat, poultry and other foodstuffs.
Chemical ID: MESH:D010126
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a1increases expressionEXP 6480464CTDOzone results in increased expression of CYP1A1 mRNAPMID:23805001
Cyp1a1multiple interactionsEXP 6480464CTD[Ozone co-treated with Particulate Matter] results in increased expression of CYP1A1 mRNAPMID:23805001
Cyp1a1decreases expressionISOCyp1a1 (Mus musculus)6480464CTDOzone results in decreased expression of CYP1A1 mRNAPMID:31626304
Cyp1a1increases expressionISOCYP1A1 (Homo sapiens)6480464CTDOzone results in increased expression of CYP1A1 mRNA; Ozone results in increased expression of CYP1A1 proteinPMID:19536146
Cyp1a1multiple interactionsISOCyp1a1 (Mus musculus)6480464CTD[Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased expression of CYP1A1 mRNAPMID:34911549
Cyp1a1multiple interactionsISOCYP1A1 (Homo sapiens)6480464CTD[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of CYP1A1 mRNA; [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of CYP1A1 mRNA; [Volatile Organic Compounds co-treated with Ozone] results in increased oxidation of CYP1A1 mRNA; AHR protein affects the reaction [Ozone results in increased expression of CYP1A1 mRNA]; AHR protein affects the reaction [Ozone results in increased expression of CYP1A1 protein]PMID:19536146 PMID:32699268
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