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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2458
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a1
Name: cytochrome P450, family 1, subfamily a, polypeptide 1
Acc ID: CHEBI:4811
Term: epoxiconazole
Definition: A racemate composed of equimolar amounts of (2S,3R)- and (2R,3S)-epoxiconazole. A broad-spectrum fungicide for control of diseases caused by Ascomycetes, Basidiomycetes and Deuteromycetes. Epoxiconazole is moderately toxic to birds, honeybees, earthworms and most aquatic organisms.
Chemical ID: MESH:C109476
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a1increases activityEXP 6480464CTDepoxiconazole results in increased activity of CYP1A1 proteinPMID:29038839
Cyp1a1increases expressionEXP 6480464CTDepoxiconazole results in increased expression of CYP1A1 mRNAPMID:25182419 PMID:29038839
Cyp1a1multiple interactionsEXP 6480464CTD[epoxiconazole co-treated with cyproconazole] results in increased activity of CYP1A1 protein; [epoxiconazole co-treated with cyproconazole] results in increased expression of CYP1A1 mRNA; [prochloraz co-treated with epoxiconazole co-treated with cyproconazole] results in increased activity of CYP1A1 protein; [prochloraz co-treated with epoxiconazole co-treated with cyproconazole] results in increased expression of CYP1A1 mRNAPMID:29038839
Cyp1a1increases expressionISOCYP1A1 (Homo sapiens)6480464CTDepoxiconazole results in increased expression of CYP1A1 mRNA; epoxiconazole results in increased expression of CYP1A1 proteinPMID:25233012 PMID:29294346 PMID:32194361
Cyp1a1multiple interactionsISOCYP1A1 (Homo sapiens)6480464CTD2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [epoxiconazole results in increased expression of CYP1A1 mRNA]; [fluxapyroxad co-treated with epoxiconazole] results in increased expression of CYP1A1 mRNA; [fluxapyroxad co-treated with epoxiconazole] results in increased expression of CYP1A1 proteinPMID:25233012 PMID:29294346
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