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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2458
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a1
Name: cytochrome P450, family 1, subfamily a, polypeptide 1
Acc ID: CHEBI:28694
Term: copper atom
Definition: A copper group element atom that has formula Cu.
Chemical ID: MESH:D003300
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a1decreases expressionEXP 6480464CTDCopper results in decreased expression of CYP1A1 mRNAPMID:22465980
Cyp1a1increases expressionISOCyp1a1 (Mus musculus)6480464CTDCopper results in increased expression of CYP1A1 mRNAPMID:15297030 PMID:16093525 PMID:18078826
Cyp1a1increases stabilityISOCyp1a1 (Mus musculus)6480464CTDCopper results in increased stability of CYP1A1 proteinPMID:16093525
Cyp1a1multiple interactionsISOCyp1a1 (Mus musculus)6480464CTDbenzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Copper results in increased expression of CYP1A1 mRNA]; Buthionine Sulfoximine promotes the reaction [Copper inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]]; Copper inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; Copper inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; Copper inhibits the reaction [beta-Naphthoflavone results in increased activity of CYP1A1 protein]; Copper inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; Copper inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 protein]; Copper inhibits the reaction [Methylcholanthrene results in increased activity of CYP1A1 protein]; Copper inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; Copper inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 protein]; Copper inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; Copper inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; Copper inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]; Cycloheximide promotes the reaction [Copper results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [Copper results in increased expression of CYP1A1 mRNA]; pyrazolanthrone inhibits the reaction [Copper results in increased expression of CYP1A1 mRNA]; pyrazolanthrone promotes the reaction [Copper inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]]; pyrrolidine dithiocarbamic acid promotes the reaction [Copper results in increased expression of CYP1A1 mRNA]; Tetradecanoylphorbol Acetate inhibits the reaction [Copper results in increased expression of CYP1A1 mRNA]; Tetradecanoylphorbol Acetate promotes the reaction [Copper inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]]; U 0126 inhibits the reaction [Copper inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]]; U 0126 promotes the reaction [Copper results in increased expression of CYP1A1 mRNA]PMID:15297030 PMID:16093525 PMID:18078826
Cyp1a1multiple interactionsISOCYP1A1 (Homo sapiens)6480464CTD[CYP1A1 protein co-treated with Copper] results in increased activity of EugenolPMID:15576237
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