GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cyp1a1 | decreases expression | EXP | | 6480464 | CTD | Copper results in decreased expression of CYP1A1 mRNA | PMID:22465980 | Cyp1a1 | increases expression | ISO | Cyp1a1 (Mus musculus) | 6480464 | CTD | Copper results in increased expression of CYP1A1 mRNA | PMID:15297030 PMID:16093525 PMID:18078826 | Cyp1a1 | increases stability | ISO | Cyp1a1 (Mus musculus) | 6480464 | CTD | Copper results in increased stability of CYP1A1 protein | PMID:16093525 | Cyp1a1 | multiple interactions | ISO | Cyp1a1 (Mus musculus) | 6480464 | CTD | benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Copper results in increased expression of CYP1A1 mRNA]; Buthionine Sulfoximine promotes the reaction [Copper inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]]; Copper inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; Copper inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; Copper inhibits the reaction [beta-Naphthoflavone results in increased activity of CYP1A1 protein]; Copper inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; Copper inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 protein]; Copper inhibits the reaction [Methylcholanthrene results in increased activity of CYP1A1 protein]; Copper inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; Copper inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 protein]; Copper inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; Copper inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; Copper inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]; Cycloheximide promotes the reaction [Copper results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [Copper results in increased expression of CYP1A1 mRNA]; pyrazolanthrone inhibits the reaction [Copper results in increased expression of CYP1A1 mRNA]; pyrazolanthrone promotes the reaction [Copper inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]]; pyrrolidine dithiocarbamic acid promotes the reaction [Copper results in increased expression of CYP1A1 mRNA]; Tetradecanoylphorbol Acetate inhibits the reaction [Copper results in increased expression of CYP1A1 mRNA]; Tetradecanoylphorbol Acetate promotes the reaction [Copper inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]]; U 0126 inhibits the reaction [Copper inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]]; U 0126 promotes the reaction [Copper results in increased expression of CYP1A1 mRNA] | PMID:15297030 PMID:16093525 PMID:18078826 | Cyp1a1 | multiple interactions | ISO | CYP1A1 (Homo sapiens) | 6480464 | CTD | [CYP1A1 protein co-treated with Copper] results in increased activity of Eugenol | PMID:15576237 | |
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