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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2458
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a1
Name: cytochrome P450, family 1, subfamily a, polypeptide 1
Acc ID: CHEBI:82312
Term: 7H-Dibenzo[c,g]carbazole
Definition: A carbazole that has formula C20H13N.
Chemical ID: MESH:C013478
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a1increases expressionEXP 6480464CTD7H-dibenzo(c,g)carbazole results in increased expression of CYP1A1 mRNAPMID:23639521
Cyp1a1multiple interactionsEXP 6480464CTD7H-dibenzo(c,g)carbazole inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]PMID:23639521
Cyp1a1increases expressionISOCYP1A1 (Homo sapiens)6480464CTD7H-dibenzo(c,g)carbazole results in increased expression of CYP1A1 mRNAPMID:23639521
Cyp1a1multiple interactionsISOCYP1A1 (Homo sapiens)6480464CTD7H-dibenzo(c,g)carbazole promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; Benzo(a)pyrene promotes the reaction [7H-dibenzo(c,g)carbazole results in increased expression of CYP1A1 mRNA]; CYP1A1 protein affects the metabolism of and results in increased activity of 7H-dibenzo(c,g)carbazole; CYP1A1 protein results in decreased susceptibility to [Benzo(a)pyrene co-treated with 7H-dibenzo(c,g)carbazole]PMID:15534862 PMID:23639521
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