GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cyp1a1 | increases expression | EXP | | 6480464 | CTD | Ethanol results in increased expression of CYP1A1 mRNA; Ethanol results in increased expression of CYP1A1 protein | PMID:23273579 PMID:26747958 | Cyp1a1 | multiple interactions | EXP | | 6480464 | CTD | [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] co-treated with zinc protoporphyrin] results in increased expression of CYP1A1 protein; [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in decreased expression of CYP1A1 protein; Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in decreased expression of CYP1A1 protein] | PMID:26747958 | Cyp1a1 | increases expression | ISO | Cyp1a1 (Mus musculus) | 6480464 | CTD | Ethanol results in increased expression of CYP1A1 mRNA | PMID:22486318 | Cyp1a1 | multiple interactions | ISO | Cyp1a1 (Mus musculus) | 6480464 | CTD | [Ethanol promotes the reaction [AHR protein binds to CYP1A1 promoter]] which results in increased expression of CYP1A1 mRNA; Ethanol inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; Ethanol inhibits the reaction [Ethanol results in increased expression of CYP1A1 mRNA]; Ethanol promotes the reaction [AHR protein binds to CYP1A1 promoter] | PMID:22486318 | Cyp1a1 | multiple interactions | ISO | CYP1A1 (Homo sapiens) | 6480464 | CTD | [[Gasoline co-treated with Ethanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of CYP1A1 mRNA | PMID:29432896 | | ||||||||||||||||||||||
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