GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cyp1a1 | multiple interactions | EXP | | 6480464 | CTD | anthracene inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA] | PMID:15315710 | Cyp1a1 | increases activity | ISO | CYP1A1 (Homo sapiens) | 6480464 | CTD | anthracene results in increased activity of CYP1A1 protein | PMID:19362136 | Cyp1a1 | increases expression | ISO | CYP1A1 (Homo sapiens) | 6480464 | CTD | anthracene results in increased expression of CYP1A1 mRNA | PMID:21668866 | Cyp1a1 | multiple interactions | ISO | CYP1A1 (Homo sapiens) | 6480464 | CTD | [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] affects the expression of CYP1A1 mRNA; [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] affects the expression of CYP1A1 protein; [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of CYP1A1 protein; AHRR protein affects the reaction [[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of CYP1A1 protein]; alyssin inhibits the reaction [anthracene results in increased activity of CYP1A1 protein]; sulforaphane inhibits the reaction [anthracene results in increased activity of CYP1A1 protein] | PMID:19362136 PMID:28710019 PMID:30980910 | |
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