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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2458
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a1
Name: cytochrome P450, family 1, subfamily a, polypeptide 1
Acc ID: CHEBI:82285
Term: ortho-Aminoazotoluene
Definition: An azobenzene that has formula C14H15N3.
Chemical ID: MESH:D009762
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a1increases activityISOCyp1a1 (Mus musculus)6480464CTDo-Aminoazotoluene results in increased activity of CYP1A1 proteinPMID:15863256
Cyp1a1increases expressionISOCyp1a1 (Mus musculus)6480464CTDo-Aminoazotoluene results in increased expression of CYP1A1 mRNAPMID:10887293 PMID:14562683
Cyp1a1multiple interactionsISOCyp1a1 (Mus musculus)6480464CTDAHR protein affects the reaction [o-Aminoazotoluene affects the expression of CYP1A1 mRNA]PMID:12700417
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