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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2458
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a1
Name: cytochrome P450, family 1, subfamily a, polypeptide 1
Acc ID: CHEBI:2825
Term: aristolochic acid A
Definition: An aristolochic acid that is phenanthrene-1-carboxylic acid that is substituted by a methylenedioxy group at the 3,4 positions, by a methoxy group at position 8, and by a nitro group at position 10. It is the most abundant of the aristolochic acids and is found in almost all Aristolochia (birthworts or pipevines) species. It has been tried in a number of treatments for inflammatory disorders, mainly in Chinese and folk medicine. However, there is concern over their use as aristolochic acid is both carcinogenic and nephrotoxic.
Chemical ID: MESH:C000228
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a1decreases expressionEXP 6480464CTDaristolochic acid I results in decreased expression of CYP1A1 mRNAPMID:36863539
Cyp1a1increases abundanceEXP 6480464CTDCYP1A1 protein results in increased abundance of aristolochic acid I metabolitePMID:21362632
Cyp1a1increases expressionEXP 6480464CTDaristolochic acid I results in increased expression of CYP1A1 mRNAPMID:26845733
Cyp1a1increases metabolic processingEXP 6480464CTDCYP1A1 protein results in increased metabolism of aristolochic acid IPMID:21362632 PMID:26845733
Cyp1a1multiple interactionsEXP 6480464CTD1-phenylazo-2-naphthol promotes the reaction [aristolochic acid I results in increased expression of and results in increased activity of CYP1A1 protein]; [1-phenylazo-2-naphthol co-treated with aristolochic acid I] results in increased expression of CYP1A1 mRNA; aristolochic acid I results in increased expression of and results in increased activity of CYP1A1 protein; Oxygen deficiency affects the reaction [CYP1A1 protein results in increased metabolism of aristolochic acid I]PMID:26845733
Cyp1a1increases expressionISOCyp1a1 (Mus musculus)6480464CTDaristolochic acid I results in increased expression of CYP1A1 mRNAPMID:25230394
Cyp1a1increases expressionISOCYP1A1 (Homo sapiens)6480464CTDaristolochic acid I results in increased expression of CYP1A1 mRNAPMID:33212167
Cyp1a1increases metabolic processingISOCYP1A1 (Homo sapiens)6480464CTDCYP1A1 protein results in increased metabolism of aristolochic acid IPMID:26845733
Cyp1a1increases oxidationISOCYP1A1 (Homo sapiens)6480464CTDCYP1A1 protein results in increased oxidation of aristolochic acid IPMID:22086975
Cyp1a1multiple interactionsISOCyp1a1 (Mus musculus)6480464CTD[[alpha-naphthoflavone results in decreased activity of CYP1A2 protein] co-treated with [alpha-naphthoflavone results in decreased activity of CYP1A1 protein]] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]; [CYP1A1 protein co-treated with CYP1A2 protein] affects the reaction [[Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]]; [CYP1A1 protein results in increased oxidation of aristolochic acid I] which results in increased abundance of aristolochic acid I metabolite; [ellipticine results in decreased activity of CYP1A1 protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]; CYP1A1 protein affects the reaction [[Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]]; CYP1A1 protein promotes the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]; CYP1A1 protein results in increased reduction of and results in increased oxidation of and affects the activity of aristolochic acid IPMID:21932800
Cyp1a1multiple interactionsISOCYP1A1 (Homo sapiens)6480464CTD[CYP1A1 protein results in increased oxidation of aristolochic acid I] which results in increased chemical synthesis of aristolochic acid I metabolite; CYP1A1 protein results in increased reduction of and results in increased activity of aristolochic acid I; Oxygen deficiency affects the reaction [CYP1A1 protein results in increased metabolism of aristolochic acid I]PMID:22086975 PMID:26845733
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