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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2458
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a1
Name: cytochrome P450, family 1, subfamily a, polypeptide 1
Acc ID: CHEBI:50131
Term: 5-aza-2'-deoxycytidine
Definition: A 2'-deoxyribonucleoside that has formula C8H12N4O4.
Chemical ID: MESH:C014347
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a1multiple interactionsEXP 6480464CTD[Decitabine co-treated with Hydroxamic Acids analog] results in increased expression of CYP1A1; Decitabine promotes the reaction [6-formylindolo(3,2-b)carbazole results in increased expression of CYP1A1 mRNA]PMID:21445578 PMID:31626383
Cyp1a1increases expressionISOCYP1A1 (Homo sapiens)6480464CTDDecitabine results in increased expression of CYP1A1 mRNAPMID:21515334
Cyp1a1multiple interactionsISOCyp1a1 (Mus musculus)6480464CTDDecitabine promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]PMID:20116417
Cyp1a1multiple interactionsISOCYP1A1 (Homo sapiens)6480464CTDDecitabine affects the reaction [Curcumin affects the reaction [6-formylindolo(3,2-b)carbazole results in increased expression of CYP1A1 mRNA]]; Decitabine promotes the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP1A1 mRNA]; Decitabine promotes the reaction [6-formylindolo(3,2-b)carbazole results in increased expression of CYP1A1 mRNA]PMID:25116688 PMID:27041069
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