Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
2,3,4,7,8-pentachlorodibenzofuran results in increased expression of CYP1A1 mRNA; 2,3,4,7,8-pentachlorodibenzofuran results in increased expression of CYP1A1 protein
[Tetrachlorodibenzodioxin co-treated with 2,3,4,7,8-pentachlorodibenzofuran co-treated with 3,4,5,3',4'-pentachlorobiphenyl] results in increased activity of CYP1A1 protein
2,3,4,7,8-pentachlorodibenzofuran results in increased expression of CYP1A1 mRNA; 2,3,4,7,8-pentachlorodibenzofuran results in increased expression of CYP1A1 protein
2,3,4,7,8-pentachlorodibenzofuran promotes the reaction [AHR protein binds to CYP1A1 promoter]; 2,3,4,7,8-pentachlorodibenzofuran promotes the reaction [ARNT protein binds to CYP1A1 promoter]; 2,3,4,7,8-pentachlorodibenzofuran promotes the reaction [EP300 protein binds to CYP1A1 promoter]; 2,3,4,7,8-pentachlorodibenzofuran promotes the reaction [NCOA3 protein binds to CYP1A1 promoter]; [2,3,4,7,8-pentachlorodibenzofuran results in increased activity of AHR protein] which results in increased expression of CYP1A1 protein; AHR protein mutant form inhibits the reaction [2,3,4,7,8-pentachlorodibenzofuran results in increased expression of CYP1A1 mRNA]; AHR protein mutant form promotes the reaction [2,3,4,7,8-pentachlorodibenzofuran results in increased expression of CYP1A1 mRNA]