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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2458
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a1
Name: cytochrome P450, family 1, subfamily a, polypeptide 1
Acc ID: CHEBI:81508
Term: 2,3,4,7,8-Pentachlorodibenzofuran
Definition: A dibenzofuran that has formula C12H3Cl5O.
Chemical ID: MESH:C038890
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a1increases activityEXP 6480464CTD2,3,4,7,8-pentachlorodibenzofuran results in increased activity of CYP1A1 proteinPMID:17160103 PMID:20705892
Cyp1a1increases expressionEXP 6480464CTD2,3,4,7,8-pentachlorodibenzofuran results in increased expression of CYP1A1 mRNA; 2,3,4,7,8-pentachlorodibenzofuran results in increased expression of CYP1A1 proteinPMID:20705892 PMID:21724226 PMID:25654323 PMID:29738842
Cyp1a1multiple interactionsEXP 6480464CTD[Tetrachlorodibenzodioxin co-treated with 2,3,4,7,8-pentachlorodibenzofuran co-treated with 3,4,5,3',4'-pentachlorobiphenyl] results in increased activity of CYP1A1 proteinPMID:17342195
Cyp1a1increases activityISOCYP1A1 (Homo sapiens)6480464CTD2,3,4,7,8-pentachlorodibenzofuran results in increased activity of CYP1A1 proteinPMID:20705892
Cyp1a1increases expressionISOCyp1a1 (Mus musculus)6480464CTD2,3,4,7,8-pentachlorodibenzofuran results in increased expression of CYP1A1 mRNAPMID:23674508 PMID:24472611 PMID:24713691
Cyp1a1increases expressionISOCYP1A1 (Homo sapiens)6480464CTD2,3,4,7,8-pentachlorodibenzofuran results in increased expression of CYP1A1 mRNA; 2,3,4,7,8-pentachlorodibenzofuran results in increased expression of CYP1A1 proteinPMID:19447902 PMID:20705892 PMID:21703235 PMID:24472611 PMID:25654323 PMID:29738842
Cyp1a1multiple interactionsISOCYP1A1 (Homo sapiens)6480464CTD2,3,4,7,8-pentachlorodibenzofuran promotes the reaction [AHR protein binds to CYP1A1 promoter]; 2,3,4,7,8-pentachlorodibenzofuran promotes the reaction [ARNT protein binds to CYP1A1 promoter]; 2,3,4,7,8-pentachlorodibenzofuran promotes the reaction [EP300 protein binds to CYP1A1 promoter]; 2,3,4,7,8-pentachlorodibenzofuran promotes the reaction [NCOA3 protein binds to CYP1A1 promoter]; [2,3,4,7,8-pentachlorodibenzofuran results in increased activity of AHR protein] which results in increased expression of CYP1A1 protein; AHR protein mutant form inhibits the reaction [2,3,4,7,8-pentachlorodibenzofuran results in increased expression of CYP1A1 mRNA]; AHR protein mutant form promotes the reaction [2,3,4,7,8-pentachlorodibenzofuran results in increased expression of CYP1A1 mRNA]PMID:11294989 PMID:21703235
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