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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2458
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a1
Name: cytochrome P450, family 1, subfamily a, polypeptide 1
Acc ID: CHEBI:109895
Term: beta-carboline
Definition: The parent compound of the beta-carbolines, a tricyclic structure comprising an indole ring system ortho- fused to C-3 and C-4 of a pyridine ring.
Chemical ID: MESH:C010262
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a1increases expressionISOCyp1a1 (Mus musculus)6480464CTDnorharman results in increased expression of CYP1A1 mRNA; norharman results in increased expression of CYP1A1 proteinPMID:28336214
Cyp1a1multiple interactionsISOCYP1A1 (Homo sapiens)6480464CTDCYP1A1 protein affects the metabolism of [norharman co-treated with aniline]PMID:15279827
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