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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2458
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a1
Name: cytochrome P450, family 1, subfamily a, polypeptide 1
Acc ID: CHEBI:34069
Term: 1,8-Dinitropyrene
Definition: A pyrene that has formula C16H8N2O4.
Chemical ID: MESH:C033310
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a1affects metabolic processingEXP 6480464CTDCYP1A1 protein affects the metabolism of 1,8-dinitropyrenePMID:2180560
Cyp1a1increases expressionISOCyp1a1 (Mus musculus)6480464CTD1,8-dinitropyrene results in increased expression of CYP1A1 proteinPMID:17240030
Cyp1a1increases expressionISOCYP1A1 (Homo sapiens)6480464CTD1,8-dinitropyrene results in increased expression of CYP1A1 mRNAPMID:12107646
Cyp1a1multiple interactionsISOCYP1A1 (Homo sapiens)6480464CTD[CYP1A1 protein co-treated with POR protein] results in increased metabolism of 1,8-dinitropyrenePMID:11113705
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