GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cyp1a1 | multiple interactions | EXP | | 6480464 | CTD | [[CYP1A1 protein co-treated with POR protein co-treated with EPHX1 protein] results in increased oxidation of Benzo(a)pyrene] which results in increased abundance of benzo(a)pyrene 7,8-dihydrodiol | PMID:24530354 | Cyp1a1 | increases chemical synthesis | ISO | CYP1A1 (Homo sapiens) | 6480464 | CTD | CYP1A1 protein results in increased chemical synthesis of benzo(a)pyrene 7,8-dihydrodiol | PMID:19879933 | Cyp1a1 | increases expression | ISO | CYP1A1 (Homo sapiens) | 6480464 | CTD | benzo(a)pyrene 7,8-dihydrodiol results in increased expression of CYP1A1 mRNA | PMID:10706104 PMID:21028851 | Cyp1a1 | multiple interactions | ISO | Cyp1a1 (Mus musculus) | 6480464 | CTD | [CYP1A1 protein results in increased metabolism of Benzo(a)pyrene] which results in increased abundance of benzo(a)pyrene 7,8-dihydrodiol | PMID:2154339 PMID:24530354 | Cyp1a1 | multiple interactions | ISO | CYP1A1 (Homo sapiens) | 6480464 | CTD | [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA] which results in increased secretion of benzo(a)pyrene 7,8-dihydrodiol; benzo(a)pyrene 7,8-dihydrodiol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; CYP1A1 protein affects the metabolism of and results in increased activity of benzo(a)pyrene 7,8-dihydrodiol; CYP1A1 protein promotes the reaction [benzo(a)pyrene 7,8-dihydrodiol results in increased mutagenesis of HPRT1 gene]; GSTM1 protein inhibits the reaction [CYP1A1 protein promotes the reaction [benzo(a)pyrene 7,8-dihydrodiol results in increased mutagenesis of HPRT1 gene]]; hyperforin inhibits the reaction [CYP1A1 protein affects the metabolism of benzo(a)pyrene 7,8-dihydrodiol]; hypericin inhibits the reaction [CYP1A1 protein affects the metabolism of benzo(a)pyrene 7,8-dihydrodiol]; Medroxyprogesterone Acetate inhibits the reaction [benzo(a)pyrene 7,8-dihydrodiol results in increased expression of CYP1A1 mRNA]; pseudohypericin inhibits the reaction [CYP1A1 protein affects the metabolism of benzo(a)pyrene 7,8-dihydrodiol]; Quercetin inhibits the reaction [CYP1A1 protein affects the metabolism of benzo(a)pyrene 7,8-dihydrodiol]; Ursodeoxycholic Acid inhibits the reaction [benzo(a)pyrene 7,8-dihydrodiol results in increased expression of CYP1A1 mRNA] | PMID:10706104 PMID:14633740 PMID:15720144 PMID:17525473 PMID:21028851 PMID:32227843 | | ||||||||||||||||||||||
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