GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cyp1a1 | affects expression | ISO | CYP1A1 (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide affects the expression of CYP1A1 mRNA | PMID:11678611 | Cyp1a1 | decreases expression | ISO | CYP1A1 (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide results in decreased expression of CYP1A1 mRNA | PMID:35872050 | Cyp1a1 | increases expression | ISO | CYP1A1 (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide results in increased expression of CYP1A1 mRNA | PMID:17530438 PMID:27829220 | Cyp1a1 | multiple interactions | ISO | Cyp1a1 (Mus musculus) | 6480464 | CTD | Arsenic Trioxide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of and results in increased activity of CYP1A1 protein]; Arsenic Trioxide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] | PMID:35872050 | Cyp1a1 | multiple interactions | ISO | CYP1A1 (Homo sapiens) | 6480464 | CTD | [Tretinoin co-treated with Arsenic Trioxide] results in increased expression of CYP1A1 mRNA; Arsenic Trioxide inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; Arsenic Trioxide inhibits the reaction [Dioxins results in increased activity of CYP1A1 protein]; Arsenic Trioxide inhibits the reaction [Methylcholanthrene results in increased expression of and results in increased activity of CYP1A1 protein]; Arsenic Trioxide inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; Arsenic Trioxide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of and results in increased activity of CYP1A1 protein]; Arsenic Trioxide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; verlukast promotes the reaction [Arsenic Trioxide results in decreased activity of CYP1A1 protein] | PMID:12490585 PMID:15894607 PMID:35872050 | |
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