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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2458
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a1
Name: cytochrome P450, family 1, subfamily a, polypeptide 1
Acc ID: CHEBI:30621
Term: diarsenic trioxide
Definition: An arsenic oxide in which arsenic and oxygen atoms are present in the ratio 2:3.
Chemical ID: MESH:C006632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a1affects expressionISOCYP1A1 (Homo sapiens)6480464CTDArsenic Trioxide affects the expression of CYP1A1 mRNAPMID:11678611
Cyp1a1decreases expressionISOCYP1A1 (Homo sapiens)6480464CTDArsenic Trioxide results in decreased expression of CYP1A1 mRNAPMID:35872050
Cyp1a1increases expressionISOCYP1A1 (Homo sapiens)6480464CTDArsenic Trioxide results in increased expression of CYP1A1 mRNAPMID:17530438 PMID:27829220
Cyp1a1multiple interactionsISOCyp1a1 (Mus musculus)6480464CTDArsenic Trioxide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of and results in increased activity of CYP1A1 protein]; Arsenic Trioxide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]PMID:35872050
Cyp1a1multiple interactionsISOCYP1A1 (Homo sapiens)6480464CTD[Tretinoin co-treated with Arsenic Trioxide] results in increased expression of CYP1A1 mRNA; Arsenic Trioxide inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; Arsenic Trioxide inhibits the reaction [Dioxins results in increased activity of CYP1A1 protein]; Arsenic Trioxide inhibits the reaction [Methylcholanthrene results in increased expression of and results in increased activity of CYP1A1 protein]; Arsenic Trioxide inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; Arsenic Trioxide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of and results in increased activity of CYP1A1 protein]; Arsenic Trioxide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; verlukast promotes the reaction [Arsenic Trioxide results in decreased activity of CYP1A1 protein]PMID:12490585 PMID:15894607 PMID:35872050
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