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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2458
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a1
Name: cytochrome P450, family 1, subfamily a, polypeptide 1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a1increases expression EXP 401794453RGDbenzo[a]pyrene increases expression of mRNA, protein in rat heart 
Cyp1a1increases expressionISOCYP1A1 (Homo sapiens)152975620RGDbenzo[a]pyrene increases expression of CYP1A1 mRNA in lung epithelial cell 
Cyp1a1affects expressionEXP 6480464CTDBenzo(a)pyrene affects the expression of CYP1A1 mRNAPMID:27099206
Cyp1a1increases activityEXP 6480464CTDBenzo(a)pyrene results in increased activity of CYP1A1 mRNA; Benzo(a)pyrene results in increased activity of CYP1A1 protein; CYP1A1 protein results in increased activity of Benzo(a)pyrenePMID:10190573 PMID:1316759 PMID:15315710 PMID:15822858 PMID:16906435 PMID:18493746 PMID:19497421 PMID:21505853 PMID:29649501 PMID:35437857 PMID:8079350
Cyp1a1increases expressionEXP 6480464CTDBenzo(a)pyrene results in increased expression of CYP1A1 mRNA; Benzo(a)pyrene results in increased expression of CYP1A1 proteinPMID:10190573 PMID:1316759 PMID:15211619 PMID:15315710 PMID:16198082 PMID:16237193 PMID:17141280 PMID:17961608 PMID:18711122 PMID:19497421 PMID:19889059 PMID:20412032 PMID:21383588 PMID:21604763 PMID:21745554 PMID:21942922 PMID:22643862 PMID:22785257 PMID:22960446 PMID:23639521 PMID:24657529 PMID:25489928 PMID:26466350 PMID:29649501 PMID:34283317 PMID:37189300 PMID:8079350 PMID:8902619 PMID:9395520
Cyp1a1multiple interactionsEXP 6480464CTD1,2,5,6-dibenzanthracene affects the reaction [Benzo(a)pyrene affects the expression of CYP1A1 mRNA]; 1,2,5,6-dibenzanthracene promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; 1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; 1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; 1-methylphenanthrene affects the reaction [Benzo(a)pyrene affects the expression of CYP1A1 mRNA]; 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; 7-ketocholesterol inhibits the reaction [[Benzo(a)pyrene co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of CYP1A1 mRNA]; 7-ketocholesterol inhibits the reaction [[Benzo(a)pyrene co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of CYP1A1 protein]; 7H-dibenzo(c,g)carbazole inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; [[CYP1A1 protein co-treated with POR protein co-treated with EPHX1 protein] results in increased oxidation of Benzo(a)pyrene] which results in increased abundance of benzo(a)pyrene 7,8-dihydrodiol; [[CYP1A1 protein co-treated with POR protein] results in increased oxidation of Benzo(a)pyrene] which results in increased abundance of benzo(a)pyrene-DNA adduct; [Benzo(a)pyrene co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of CYP1A1 mRNA; [Benzo(a)pyrene co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of CYP1A1 protein; [Benzo(a)pyrene co-treated with GNMT protein] results in increased expression of CYP1A1 mRNA; [Benzo(a)pyrene co-treated with GNMT protein] results in increased expression of CYP1A1 protein; [Benzo(a)pyrene co-treated with Oxygen] affects the expression of CYP1A1 protein; [chrysene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene] promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; [chrysene co-treated with benz(a)anthracene] promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; [chrysene co-treated with Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene] results in increased expression of CYP1A1 mRNA; [chrysene co-treated with Benzo(a)pyrene co-treated with benz(a)anthracene] results in increased expression of CYP1A1 mRNA; [chrysene co-treated with Benzo(a)pyrene] results in increased expression of CYP1A1 mRNA; [CYP1A1 protein co-treated with CYB5A protein] results in increased oxidation of Benzo(a)pyrene; [CYP1A1 protein co-treated with POR protein co-treated with EPHX1 protein] results in increased oxidation of Benzo(a)pyrene; [CYP1A1 protein co-treated with POR protein] results in increased oxidation of Benzo(a)pyrene; acetyl-11-ketoboswellic acid inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; AHR affects the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; AHR protein affects the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; anthracene inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; Benzo(a)pyrene promotes the reaction [1,2,5,6-dibenzanthracene results in increased expression of CYP1A1 mRNA]; Benzo(a)pyrene promotes the reaction [benzo(b)fluoranthene results in increased expression of CYP1A1 mRNA]; Benzo(a)pyrene promotes the reaction [CD40LG protein results in increased expression of CYP1A1 mRNA]; Benzo(a)pyrene promotes the reaction [fluoranthene results in increased expression of CYP1A1 mRNA]; Benzo(a)pyrene results in increased expression of and results in increased activity of CYP1A1 protein; benzo(b)fluoranthene affects the reaction [Benzo(a)pyrene affects the expression of CYP1A1 mRNA]; benzo(b)fluoranthene promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; chrysene inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; CYB5A protein promotes the reaction [[[CYP1A1 protein co-treated with POR protein] results in increased oxidation of Benzo(a)pyrene] which results in increased abundance of benzo(a)pyrene-DNA adduct]; CYB5A protein promotes the reaction [[CYP1A1 protein co-treated with POR protein] results in increased oxidation of Benzo(a)pyrene]; dibenzo(a,l)pyrene affects the reaction [Benzo(a)pyrene affects the expression of CYP1A1 mRNA]; dibenzo(a,l)pyrene promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; Drugs, Chinese Herbal inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; EPHX1 protein affects the reaction [CYB5A protein promotes the reaction [[[CYP1A1 protein co-treated with POR protein] results in increased oxidation of Benzo(a)pyrene] which results in increased abundance of benzo(a)pyrene-DNA adduct]]; erucin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; Ethinyl Estradiol inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; Ethinyl Estradiol inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; ferric oxide promotes the reaction [Benzo(a)pyrene results in increased expression of and results in increased activity of CYP1A1 protein]; ferric oxide promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; fluoranthene affects the reaction [Benzo(a)pyrene affects the expression of CYP1A1 mRNA]; fluoranthene promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; INS1 protein inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; lead nitrate inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; Oxygen inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; Phenobarbital promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; Resveratrol inhibits the reaction [[Benzo(a)pyrene co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of CYP1A1 protein]; Staurosporine inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; sulforaphane analog inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; Sulpiride inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; Tetrachlorodibenzodioxin promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; TNF inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; TNF protein inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; TNF protein inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; Wortmannin inhibits the reaction [INS1 protein inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]]PMID:10496962 PMID:11042205 PMID:15211619 PMID:15315710 PMID:15681594 PMID:16198082 PMID:16901605 PMID:17141280 PMID:18711122 PMID:19497421 PMID:21383588 PMID:21745554 PMID:22643862 PMID:22785257 PMID:23639521 PMID:24530354 PMID:24657529 PMID:25233930 PMID:25489928 PMID:26466350 PMID:27099206 PMID:29649501 PMID:35437857 PMID:37189300 PMID:8902619 PMID:9261130 PMID:9395520
Cyp1a1affects activityISOCYP1A1 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the activity of CYP1A1 proteinPMID:37515497
Cyp1a1affects expressionISOCYP1A1 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the expression of CYP1A1 mRNAPMID:20624995 PMID:26474839
Cyp1a1affects metabolic processingISOCyp1a1 (Mus musculus)6480464CTDCYP1A1 protein affects the metabolism of Benzo(a)pyrenePMID:20371670
Cyp1a1affects metabolic processingISOCYP1A1 (Homo sapiens)6480464CTDCYP1A1 protein affects the metabolism of Benzo(a)pyrenePMID:20542099
Cyp1a1affects methylationISOCYP1A1 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of CYP1A1 promoterPMID:27901495
Cyp1a1affects response to substanceISOCyp1a1 (Mus musculus)6480464CTDCYP1A1 protein affects the susceptibility to Benzo(a)pyrenePMID:20127859
Cyp1a1decreases activityISOCyp1a1 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased activity of CYP1A1 proteinPMID:15621696
Cyp1a1decreases expressionISOCYP1A1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of CYP1A1 mRNAPMID:32234424
Cyp1a1increases activityISOCyp1a1 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased activity of CYP1A1 protein; CYP1A1 protein results in increased activity of Benzo(a)pyrenePMID:15297030 PMID:15337587 PMID:15606143 PMID:15863256 PMID:18057710 PMID:18321868 PMID:21715664 PMID:25911668 PMID:36193556
Cyp1a1increases activityISOCYP1A1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased activity of CYP1A1 mRNA; Benzo(a)pyrene results in increased activity of CYP1A1 protein; CYP1A1 results in increased activity of Benzo(a)pyrenePMID:11408366 PMID:11752233 PMID:12641979 PMID:15905203 PMID:17065433 PMID:18493746 PMID:19070657 PMID:19202560 PMID:19553035 PMID:20888851 PMID:21329749 PMID:21913209 PMID:22037238 PMID:25082669 PMID:26474839 PMID:33411230
Cyp1a1increases expressionISOCyp1a1 (Mus musculus)6480464CTDBenzo(a)pyrene metabolite results in increased expression of CYP1A1 mRNA; Benzo(a)pyrene results in increased expression of CYP1A1; Benzo(a)pyrene results in increased expression of CYP1A1 mRNA; Benzo(a)pyrene results in increased expression of CYP1A1 proteinPMID:11171528 PMID:11356909 PMID:11577022 PMID:12117779 PMID:14562683 PMID:14625279 PMID:14645679 PMID:15297030 PMID:15316568 PMID:15337587 PMID:15621696 PMID:17060372 PMID:17275222 PMID:17682057 PMID:17997381 PMID:18321868 PMID:1849469 PMID:19406224 PMID:19428948 PMID:19449198 PMID:19573549 PMID:19666105 PMID:19770486 PMID:19896525 PMID:19961161 PMID:20371670 PMID:20570689 PMID:20713471 PMID:20869020 PMID:21567390 PMID:21569818 PMID:21715664 PMID:21978865 PMID:22120587 PMID:22486318 PMID:22761424 PMID:22935520 PMID:23274566 PMID:23747951 PMID:24374135 PMID:24530354 PMID:25230394 PMID:25908611 PMID:25911668 PMID:26377693 PMID:26546711 PMID:26656082 PMID:27286660 PMID:27869817 PMID:29368147 PMID:29906497 PMID:30165701 PMID:31830554 PMID:32417428 PMID:32553695 PMID:33393179 PMID:34472326 PMID:34998820 PMID:9325024
Cyp1a1increases expressionISOCYP1A1 (Homo sapiens)6480464CTDBenzo(a)pyrene analog results in increased expression of CYP1A1 mRNA; Benzo(a)pyrene analog results in increased expression of CYP1A1 protein; Benzo(a)pyrene results in increased expression of CYP1A1 mRNA; Benzo(a)pyrene results in increased expression of CYP1A1 proteinPMID:10496959 PMID:10693172 PMID:10872632 PMID:11162773 PMID:11279601 PMID:11768231 PMID:11782367 PMID:11849738 PMID:11854143 PMID:11884429 PMID:11959854 PMID:12107646 PMID:12730081 PMID:14645679 PMID:14993811 PMID:15041469 PMID:15056799 PMID:15566942 PMID:15627480 PMID:15661813 PMID:15713371 PMID:15735009 PMID:15808406 PMID:15808407 PMID:15905203 PMID:16258175 PMID:16269432 PMID:16280210 PMID:16484233 PMID:16545412 PMID:16972788 PMID:17065433 PMID:17253728 PMID:17944540 PMID:18061397 PMID:18174961 PMID:18214805 PMID:18767135 PMID:18952161 PMID:19070657 PMID:19152381 PMID:19244278 PMID:19365803 PMID:19463884 PMID:19576839 PMID:19737606 PMID:19800895 PMID:19828881 PMID:19879285 PMID:19879933 PMID:20064835 PMID:20106945 PMID:20146248 PMID:20163913 PMID:20228066 PMID:20307623 PMID:20403331 PMID:20435083 PMID:20464547 PMID:20542099 PMID:20553787 PMID:20951464 PMID:21256203 PMID:21256954 PMID:21262253 PMID:21316925 PMID:21453744 PMID:21458546 PMID:21507987 PMID:21632981 PMID:21669939 PMID:21714911 PMID:21720915 PMID:21781905 PMID:21802500 PMID:21871943 PMID:21873647 PMID:21887816 PMID:22178795 PMID:22266578 PMID:22316170 PMID:22409540 PMID:22581694 PMID:22686307 PMID:22761424 PMID:22837390 PMID:22889811 PMID:22951985 PMID:23639521 PMID:24114850 PMID:24361490 PMID:24472612 PMID:24486526 PMID:25398514 PMID:25690898 PMID:25929522 PMID:26238291 PMID:26350169 PMID:26438400 PMID:26621329 PMID:26657896 PMID:27196671 PMID:27752740 PMID:27825931 PMID:27830268 PMID:28238931 PMID:28351761 PMID:28461126 PMID:28882572 PMID:29471073 PMID:29545172 PMID:29549414 PMID:30248327 PMID:30294794 PMID:30439556 PMID:30453624 PMID:31087746 PMID:31096615 PMID:31111189 PMID:31255691 PMID:31515600 PMID:31542801 PMID:31830554 PMID:32227843 PMID:32244372 PMID:32890658 PMID:33249052 PMID:33393179 PMID:33411230 PMID:33421718 PMID:33961948 PMID:35870112 PMID:37515497 PMID:9860486
Cyp1a1increases hydrolysisISOCYP1A1 (Homo sapiens)6480464CTDCYP1A1 protein results in increased hydrolysis of Benzo(a)pyrenePMID:19919601
Cyp1a1increases hydroxylationISOCYP1A1 (Homo sapiens)6480464CTDCYP1A1 protein results in increased hydroxylation of Benzo(a)pyrenePMID:25902338
Cyp1a1increases metabolic processingISOCyp1a1 (Mus musculus)6480464CTDCYP1A1 protein results in increased metabolism of Benzo(a)pyrenePMID:2154339 PMID:24530354 PMID:32553695
Cyp1a1increases metabolic processingISOCYP1A1 (Homo sapiens)6480464CTDCYP1A1 protein results in increased metabolism of Benzo(a)pyrenePMID:19330882 PMID:19879933 PMID:2791199 PMID:32553695 PMID:35882637
Cyp1a1increases response to substanceISOCYP1A1 (Homo sapiens)6480464CTDCYP1A1 protein results in increased susceptibility to Benzo(a)pyrenePMID:27913846 PMID:31733235 PMID:8608954
Cyp1a1multiple interactionsISOCyp1a1 (Mus musculus)6480464CTD1,10-phenanthroline inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; [1,10-phenanthroline co-treated with cupric chloride] inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; [1,10-phenanthroline co-treated with cupric chloride] inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; [Azacitidine co-treated with Butyrates] inhibits the reaction [Chromium inhibits the reaction [Benzo(a)pyrene promotes the reaction [AHR protein binds to CYP1A1 promoter]]]; [Azacitidine co-treated with Butyrates] inhibits the reaction [Chromium inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]]; [Benzo(a)pyrene binds to and affects the localization of AHR protein] promotes the reaction [[AHR protein binds to CYP1A1 enhancer] which results in increased expression of CYP1A1 mRNA]; [Benzo(a)pyrene binds to and affects the localization of AHR protein] which results in increased expression of CYP1A1 mRNA; [Benzo(a)pyrene binds to and results in increased activity of AHR protein] which results in increased expression of CYP1A1 protein; [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of CYP1A1 mRNA; [Benzo(a)pyrene co-treated with Dietary Fats] results in increased expression of CYP1A1 mRNA; [Benzo(a)pyrene co-treated with Dietary Fats] results in increased expression of CYP1A1 protein; [Benzo(a)pyrene co-treated with sodium bichromate] results in decreased expression of CYP1A1 mRNA; [Benzo(a)pyrene results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA; [chromium hexavalent ion co-treated with Benzo(a)pyrene] affects the expression of CYP1A1 mRNA; [chromium hexavalent ion co-treated with Benzo(a)pyrene] results in increased expression of CYP1A1 protein; [CYP1A1 protein co-treated with Trichloroepoxypropane] results in increased metabolism of Benzo(a)pyrene; [CYP1A1 protein results in increased metabolism of Benzo(a)pyrene] which results in increased abundance of 4,5-dihydroxy-4,5-dihydrobenzo(a)pyrene; [CYP1A1 protein results in increased metabolism of Benzo(a)pyrene] which results in increased abundance of 9,10-dihydro-9,10-dihydroxybenzo(a)pyrene; [CYP1A1 protein results in increased metabolism of Benzo(a)pyrene] which results in increased abundance of benzo(a)pyrene 7,8-dihydrodiol; [fluoranthene co-treated with pyrene co-treated with benz(a)anthracene co-treated with chrysene co-treated with benzo(b)fluoranthene co-treated with benzo(k)fluoranthene co-treated with Benzo(a)pyrene] results in increased expression of CYP1A1 mRNA; [lipopolysaccharide, E coli O55-B5 co-treated with Benzo(a)pyrene] affects the expression of CYP1A1 mRNA; [Lipopolysaccharides inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]] which results in increased abundance of benzo(a)pyrene-DNA adduct; [Potassium Dichromate co-treated with potassium chromate(VI)] inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; Acetylcysteine inhibits the reaction [Benzo(a)pyrene results in decreased activity of CYP1A1 protein]; AHR mRNA promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1]; AHR protein affects the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; AHR protein promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; Arsenic inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; Arsenic promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; Arsenic promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; Azacitidine inhibits the reaction [Chromium inhibits the reaction [Benzo(a)pyrene promotes the reaction [AHR protein binds to CYP1A1 promoter]]]; Azacitidine inhibits the reaction [Chromium inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]]; Benzo(a)pyrene inhibits the reaction [[DNMT1 protein binds to HDAC1 protein] which binds to CYP1A1 promoter]; Benzo(a)pyrene inhibits the reaction [HDAC1 protein binds to CYP1A1 promoter]; Benzo(a)pyrene promotes the reaction [AHR protein binds to CYP1A1 promoter]; Benzo(a)pyrene promotes the reaction [Dust results in increased expression of CYP1A1 protein]; Benzo(a)pyrene promotes the reaction [sodium bichromate results in decreased expression of CYP1A1 mRNA]; Bucladesine affects the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; Butyrates inhibits the reaction [Chromium inhibits the reaction [Benzo(a)pyrene promotes the reaction [AHR protein binds to CYP1A1 promoter]]]; Butyrates inhibits the reaction [Chromium inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]]; Cadmium inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; Cadmium promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; Cadmium promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; Capsaicin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; Chromium inhibits the reaction [Benzo(a)pyrene inhibits the reaction [HDAC1 protein binds to CYP1A1 promoter]]; Chromium inhibits the reaction [Benzo(a)pyrene promotes the reaction [H3F4 protein modified form binds to CYP1A1 promoter]]; Chromium inhibits the reaction [Benzo(a)pyrene promotes the reaction [H4C16 protein modified form binds to CYP1A1 promoter]]; Chromium inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; Chromium inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; Chromium promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; Chromium promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; CLOCK gene mutant form inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; Colforsin affects the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; Copper inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; Copper inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; Cycloheximide affects the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; CYP1A1 protein results in increased metabolism of and results in decreased activity of Benzo(a)pyrene; CYP1B1 gene mutant form promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; Dextran Sulfate inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; Dust promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; EPHX1 protein promotes the reaction [CYP1A1 protein results in increased metabolism of Benzo(a)pyrene]; Ethanol inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; ferric chloride inhibits the reaction [1,10-phenanthroline inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]]; hesperetin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; Lead inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; Lead inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; Lipopolysaccharides inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; Lipopolysaccharides promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; Mercury inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; Mercury promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; Mercury promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; nickel chloride inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; pinocembrin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; Plant Extracts inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; Quercetin inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; Resveratrol inhibits the reaction [[Benzo(a)pyrene binds to and results in increased activity of AHR protein] which results in increased expression of CYP1A1 protein]; Resveratrol inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; SOD1 protein promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; SOD1 protein promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; thymoquinone inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; zinc chloride inhibits the reaction [1,10-phenanthroline inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]]PMID:11577022 PMID:12884409 PMID:14625279 PMID:14645679 PMID:15297030 PMID:15337587 PMID:15621696 PMID:17060372 PMID:17275222 PMID:17682057 PMID:18057710 PMID:18321868 PMID:1849469 PMID:19449198 PMID:19666105 PMID:19896525 PMID:20869020 PMID:21292640 PMID:2154339 PMID:21978865 PMID:22486318 PMID:22613061 PMID:24530354 PMID:25820237 PMID:25911668 PMID:26546711 PMID:27858113 PMID:27869817 PMID:28987381 PMID:30165701 PMID:31730885 PMID:31830554 PMID:32553695 PMID:33393179 PMID:34998820 PMID:36193556 PMID:7750161 PMID:8961944
Cyp1a1multiple interactionsISOCYP1A1 (Homo sapiens)6480464CTD(25S)-26-adamantyl-25-hydroxy-2-methylene-22,23-didehydro-19,27-dinor-20-epi-vitamin D3 inhibits the reaction [Calcitriol promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; 1-nitropyrene inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; 1-nitropyrene inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; 2,4,3',5'-tetramethoxystilbene promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; 2-((2,6-dichlorophenyl)amino)benzeneacetic acid 4-(3H-1,2-dithiol-3-thione-5-yl)phenyl ester inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; 2-aminoethoxydiphenyl borate inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; 2-aminoethoxydiphenyl borate inhibits the reaction [Benzo(a)pyrene results in increased secretion of CYP1A1 protein]; 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; 2-oxohexyl isothiocyanate inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; 3',4'-dimethoxyflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of and results in increased activity of CYP1A1 protein]; 3',4'-dimethoxyflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; 3'-methoxy-4'-nitroflavone inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; 3'-methoxy-4'-nitroflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; 3-methylquercetin inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; 5,7-dimethoxyflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of and results in increased activity of CYP1A1 protein]; 5,7-dimethoxyflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; 5,7-dimethoxyflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; 7H-dibenzo(c,g)carbazole promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; [2-Hydroxypropyl-beta-cyclodextrin co-treated with hesperetin] inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; [3,4,5,3',4'-pentachlorobiphenyl co-treated with Benzo(a)pyrene] results in increased activity of CYP1A1 protein; [Benzo(a)pyrene binds to and results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA; [Benzo(a)pyrene co-treated with 1,12-benzoperylene] results in increased expression of CYP1A1 mRNA; [Benzo(a)pyrene co-treated with 1,12-benzoperylene] results in increased expression of CYP1A1 protein; [Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of CYP1A1 mRNA; [Benzo(a)pyrene co-treated with 1-methylphenanthrene] affects the expression of CYP1A1 mRNA; [Benzo(a)pyrene co-treated with 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] results in increased expression of CYP1A1 mRNA; [Benzo(a)pyrene co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased expression of CYP1A1 mRNA; [Benzo(a)pyrene co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in increased expression of CYP1A1 protein; [Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of CYP1A1 mRNA; [Benzo(a)pyrene co-treated with Butyric Acid] results in increased expression of CYP1A1 mRNA; [Benzo(a)pyrene co-treated with Calcitriol] results in increased expression of CYP1A1 mRNA; [Benzo(a)pyrene results in increased activity of AHR protein] promotes the reaction [AHR protein binds to CYP1A1 promoter]; [Benzo(a)pyrene results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA; [Benzo(a)pyrene results in increased activity of and affects the localization of AHR protein] which results in increased expression of CYP1A1 mRNA; [Benzo(a)pyrene results in increased activity of and affects the localization of AHR protein] which results in increased expression of CYP1A1 protein; [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA] which results in increased secretion of 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA] which results in increased secretion of 9-hydroxybenzo(a)pyrene; [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA] which results in increased secretion of benzo(a)pyrene 7,8-dihydrodiol; [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA] which results in increased secretion of Benzo(a)pyrene metabolite; [Benzo(a)pyrene results in increased expression of CYP1A1 protein] which results in increased chemical synthesis of benzo(a)pyrene-DNA adduct; [Benzo(a)pyrene results in increased expression of CYP1A1 protein] which results in increased metabolism of Benzo(a)pyrene; [CYP1A1 protein co-treated with Trichloroepoxypropane] results in increased metabolism of Benzo(a)pyrene; [CYP1A1 protein results in increased metabolism of Benzo(a)pyrene] which results in increased expression of TP53 protein modified form; [CYP1A1 protein results in increased susceptibility to Benzo(a)pyrene] which results in increased mutagenesis of HPRT1 gene; [Docosahexaenoic Acids co-treated with Benzo(a)pyrene] results in decreased expression of CYP1A1 mRNA; [Dust co-treated with Benzo(a)pyrene] results in increased expression of CYP1A1 mRNA; [Estradiol co-treated with Benzo(a)pyrene] promotes the reaction [Oleic Acid results in increased expression of CYP1A1 mRNA]; [Estradiol co-treated with Benzo(a)pyrene] promotes the reaction [Oleic Acid results in increased expression of CYP1A1 protein]; [fluoranthene co-treated with pyrene] promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; [phenanthrene co-treated with pyrene co-treated with Benzo(a)pyrene co-treated with benzo(k)fluoranthene co-treated with dibenzo(a,l)pyrene co-treated with benzo(b)fluoranthene] results in increased expression of CYP1A1 mRNA; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin] inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] which results in increased metabolism of Benzo(a)pyrene; [TP53 protein affects the susceptibility to Benzo(a)pyrene] which results in increased expression of CYP1A1 protein; [TP53 protein binds to CYP1A1 promoter] affects the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; AHR gene mutant form inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; AHR mutant form inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; AHR protein affects the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; AHR protein promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; alizarin affects the reaction [Benzo(a)pyrene affects the activity of CYP1A1 protein]; alpha-naphthoflavone inhibits the reaction [[3,4,5,3',4'-pentachlorobiphenyl co-treated with Benzo(a)pyrene] results in increased activity of CYP1A1 protein]; alpha-naphthoflavone inhibits the reaction [[Benzo(a)pyrene binds to and results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [[Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] which results in increased metabolism of Benzo(a)pyrene]; alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [Calcitriol promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]]; alpha-naphthoflavone promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; alvocidib inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; alyssin inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; Apigenin inhibits the reaction [CYP1A1 results in increased activity of Benzo(a)pyrene]; Arsenic Trioxide inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; Benzo(a)pyrene affects the reaction [Calcitriol promotes the reaction [VDR protein binds to CYP1A1 promoter]]; Benzo(a)pyrene affects the reaction [CYP1A1 protein results in increased hydroxylation of Estradiol]; Benzo(a)pyrene binds to and results in decreased activity of CYP1A1 protein; Benzo(a)pyrene promotes the reaction [7H-dibenzo(c,g)carbazole results in increased expression of CYP1A1 mRNA]; Benzo(a)pyrene promotes the reaction [[AHR protein binds to ARNT protein] which results in increased expression of CYP1A1 mRNA]; Benzo(a)pyrene promotes the reaction [AHR protein binds to CYP1A1 promoter]; Benzo(a)pyrene promotes the reaction [AHR protein results in increased expression of CYP1A1 mRNA]; Benzo(a)pyrene promotes the reaction [ARNT protein binds to CYP1A1 promoter]; Benzo(a)pyrene promotes the reaction [Butyric Acid results in increased expression of CYP1A1 mRNA]; Benzo(a)pyrene promotes the reaction [ESR1 protein binds to CYP1A1 promoter]; Benzo(a)pyrene promotes the reaction [Estradiol results in increased expression of CYP1A1 mRNA]; Benzo(a)pyrene promotes the reaction [IL1B protein results in increased expression of CYP1A1 mRNA]; Benzo(a)pyrene results in increased expression of and affects the localization of CYP1A1 protein; Benzo(a)pyrene results in increased expression of and results in increased activity of CYP1A1 protein; BRCA1 protein affects the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; Butyric Acid promotes the reaction [[Benzo(a)pyrene results in increased expression of CYP1A1 protein] which results in increased chemical synthesis of benzo(a)pyrene-DNA adduct]; Butyric Acid promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; Butyric Acid promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; Cadmium Chloride inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; Calcitriol affects the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; Calcitriol promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; Calcitriol promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; Calcium promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; Chlorodiphenyl (54% Chlorine) promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; chlorophyllin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; chrysin inhibits the reaction [CYP1A1 results in increased activity of Benzo(a)pyrene]; chrysoeriol inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; cobaltous chloride inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; cryptotanshinone promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; cryptotanshinone promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; CXCL8 protein promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; Cycloheximide promotes the reaction [[Benzo(a)pyrene co-treated with Calcitriol] results in increased expression of CYP1A1 mRNA]; CYP1A1 protein affects the reaction [Benzo(a)pyrene results in increased expression of H2AX protein]; CYP1A1 protein polymorphism affects the metabolism of and results in increased activity of Benzo(a)pyrene; CYP1A1 protein promotes the reaction [Benzo(a)pyrene results in increased mutagenesis of HPRT1 gene]; CYP1A1 protein results in decreased susceptibility to [Benzo(a)pyrene co-treated with 7H-dibenzo(c,g)carbazole]; CYP1A1 protein results in increased metabolism of and results in increased activity of Benzo(a)pyrene; CYP1A1 protein results in increased metabolism of and results in increased susceptibility to Benzo(a)pyrene; Dasatinib inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; Dexamethasone inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; Dexmedetomidine promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; dihydrotanshinone I promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; dihydrotanshinone I promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; ellipticine inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; EPHX1 protein promotes the reaction [CYP1A1 protein results in increased metabolism of Benzo(a)pyrene]; Etoposide promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; fluoranthene promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; Grape Seed Proanthocyanidins inhibits the reaction [[Benzo(a)pyrene co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased expression of CYP1A1 mRNA]; Grape Seed Proanthocyanidins inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; Grape Seed Proanthocyanidins inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; GSTM1 protein inhibits the reaction [CYP1A1 protein promotes the reaction [Benzo(a)pyrene results in increased mutagenesis of HPRT1 gene]]; GSTM1 protein inhibits the reaction [CYP1A1 protein results in increased susceptibility to Benzo(a)pyrene]; GUSB protein affects the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; Harmaline inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; harmalol inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; Hexachlorocyclohexane inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; kaempferol inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; lead nitrate inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; lithocholic acid acetate promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; Luteolin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; mannose-6-phosphate affects the reaction [GUSB protein affects the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]]; Mercuric Chloride inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; Methyl Parathion inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; methylparaoxon inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; Mycophenolic Acid promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; nickel chloride inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; PARG affects the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; PARG affects the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; pinocembrin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; pinocembrin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; pinocembrin promotes the reaction [Dasatinib inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]]; Plant Extracts inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; Prazosin promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; Propranolol promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; PTGES3 protein affects the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; PTGES3 protein affects the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; pyrene promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; Quercetin inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; Quercetin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; Quercetin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; Quercetin promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; Reserpine promotes the reaction [Benzo(a)pyrene results in increased expression of and results in increased activity of CYP1A1 protein]; Reserpine promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; Resveratrol inhibits the reaction [[Benzo(a)pyrene results in increased activity of AHR protein] promotes the reaction [AHR protein binds to CYP1A1 promoter]]; Resveratrol inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; Resveratrol inhibits the reaction [Benzo(a)pyrene results in increased expression of and results in increased activity of CYP1A1 protein]; Resveratrol inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; S-sulindac inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; sodium arsenite inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; sodium arsenite inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; sulforaphane inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; tanshinone promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; tanshinone promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; THZ1 compound inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; TNF inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; TP53 protein affects the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; TP53 protein promotes the reaction [ellipticine inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]]; TP53 protein promotes the reaction [Etoposide promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]]; trichostatin A inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; trichostatin A promotes the reaction [[Benzo(a)pyrene results in increased expression of CYP1A1 protein] which results in increased chemical synthesis of benzo(a)pyrene-DNA adduct]; trichostatin A promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; trichostatin A promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; U 0126 inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; VDR mutant form inhibits the reaction [Calcitriol promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]]; Vorinostat promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; Vorinostat promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; wogonin affects the reaction [Benzo(a)pyrene affects the activity of CYP1A1 protein]; wogonin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]PMID:10496959 PMID:10693172 PMID:11141357 PMID:11279601 PMID:11408366 PMID:11752233 PMID:11768231 PMID:11854143 PMID:12490585 PMID:12799773 PMID:14645679 PMID:14993811 PMID:15056799 PMID:15162144 PMID:15298956 PMID:15566942 PMID:15608128 PMID:15627480 PMID:15661813 PMID:15713371 PMID:15735009 PMID:15905203 PMID:16237193 PMID:16280210 PMID:16426572 PMID:16484233 PMID:16679317 PMID:16972788 PMID:17525473 PMID:17690111 PMID:17919675 PMID:18174961 PMID:18767135 PMID:19152381 PMID:19202560 PMID:19244278 PMID:19276279 PMID:19463884 PMID:19553035 PMID:19619570 PMID:19800895 PMID:20146248 PMID:20163913 PMID:20228066 PMID:20403331 PMID:20464547 PMID:20553787 PMID:21256954 PMID:21262253 PMID:21316925 PMID:21329749 PMID:21453744 PMID:21507987 PMID:21669939 PMID:21720915 PMID:21781905 PMID:22037238 PMID:22266578 PMID:22837390 PMID:23639521 PMID:24361490 PMID:24486526 PMID:25082669 PMID:25233930 PMID:25398514 PMID:25929522 PMID:25956473 PMID:26091049 PMID:26438400 PMID:27830268 PMID:27913846 PMID:28238931 PMID:28351761 PMID:29471073 PMID:29524502 PMID:29545172 PMID:30204910 PMID:30439556 PMID:31730885 PMID:31830554 PMID:32062438 PMID:32159784 PMID:32227843 PMID:32553695 PMID:33249052 PMID:33393179 PMID:36399157 PMID:37515497 PMID:8961944
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