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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2458
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a1
Name: cytochrome P450, family 1, subfamily a, polypeptide 1
Acc ID: CHEBI:50182
Term: 3,3'-diindolylmethane
Definition: An indole that has formula C17H14N2.
Chemical ID: MESH:C016392
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a1increases expressionEXP 6480464CTD3,3'-diindolylmethane results in increased expression of CYP1A1 proteinPMID:8384853
Cyp1a1decreases activityISOCYP1A1 (Homo sapiens)6480464CTD3,3'-diindolylmethane results in decreased activity of CYP1A1 proteinPMID:11597580 PMID:19770484
Cyp1a1increases activityISOCYP1A1 (Homo sapiens)6480464CTD3,3'-diindolylmethane analog results in increased activity of CYP1A1 protein; 3,3'-diindolylmethane results in increased activity of CYP1A1 proteinPMID:11294972
Cyp1a1increases expressionISOCYP1A1 (Homo sapiens)6480464CTD3,3'-diindolylmethane analog results in increased expression of CYP1A1 mRNA; 3,3'-diindolylmethane results in increased expression of CYP1A1 mRNA; 3,3'-diindolylmethane results in increased expression of CYP1A1 proteinPMID:11179685 PMID:11294972 PMID:15672752 PMID:16972788 PMID:19770484 PMID:22495798 PMID:23583297 PMID:9771935
Cyp1a1multiple interactionsISOCYP1A1 (Homo sapiens)6480464CTD3,3'-diindolylmethane promotes the reaction [AHR protein binds to CYP1A1 promoter]; 3,3'-diindolylmethane promotes the reaction [ARNT protein binds to CYP1A1 promoter]; 3,3'-diindolylmethane promotes the reaction [ESR1 protein binds to CYP1A1 promoter]; [3,3'-diindolylmethane results in increased expression of CYP1A1 mRNA] which results in increased abundance of aflatoxin B1-DNA adductPMID:16972788 PMID:19770484
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