Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2458
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a1
Name: cytochrome P450, family 1, subfamily a, polypeptide 1
Acc ID: CHEBI:88046
Term: cylindrospermopsin
Definition: A triazaacenaphthylene that is 2,2a,3,4,5,5a,6,7-octahydro-1H-1,8,8b-triazaacenaphthylene which is substituted at positions 3, 4, and 7 by methyl, sulfooxy, and (2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)(hydroxy)methyl groups, respectively (the 2aS,3R,4S,5aS,7R stereoisomer in which the carbon bearing the hydroxy group has R configuration). It is a cyanotoxin produced by several species of freshwater cyanobacteria, such as Aphanizomenon ovalisporum.
Chemical ID: MESH:C089595
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a1decreases expressionISOCYP1A1 (Homo sapiens)6480464CTDcylindrospermopsin results in decreased expression of CYP1A1 mRNAPMID:32244372
Cyp1a1increases expressionISOCYP1A1 (Homo sapiens)6480464CTDcylindrospermopsin results in increased expression of CYP1A1 mRNAPMID:21607682 PMID:23726867 PMID:24921660
Cyp1a1multiple interactionsISOCYP1A1 (Homo sapiens)6480464CTD[4,4'-hexafluorisopropylidene diphenol co-treated with cylindrospermopsin] results in decreased expression of CYP1A1 mRNA; [bisphenol A co-treated with cylindrospermopsin] results in decreased expression of CYP1A1 mRNA; [bisphenol F co-treated with cylindrospermopsin] results in decreased expression of CYP1A1 mRNA; [bisphenol S co-treated with cylindrospermopsin] results in decreased expression of CYP1A1 mRNA; [cylindrospermopsin co-treated with 4,4'-hexafluorisopropylidene diphenol] results in increased expression of CYP1A1 mRNA; [cylindrospermopsin co-treated with bisphenol A] results in increased expression of CYP1A1 mRNA; [cylindrospermopsin co-treated with bisphenol F] results in increased expression of CYP1A1 mRNA; [cylindrospermopsin co-treated with bisphenol S] results in increased expression of CYP1A1 mRNAPMID:32244372
Go Back to source page   Continue to Ontology report