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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2458
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a1
Name: cytochrome P450, family 1, subfamily a, polypeptide 1
Acc ID: CHEBI:81517
Term: 3,4,5,3',4',5'-Hexachlorobiphenyl
Definition: A hexachlorobiphenyl that has formula C12H4Cl6.
Chemical ID: MESH:C027309
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a1increases expressionEXP 6480464CTD3,4,5,3',4',5'-hexachlorobiphenyl results in increased expression of CYP1A1 mRNA; 3,4,5,3',4',5'-hexachlorobiphenyl results in increased expression of CYP1A1 proteinPMID:25654323 PMID:29738842
Cyp1a1multiple interactionsEXP 6480464CTD[3,4,5,3',4'-pentachlorobiphenyl co-treated with 3,4,5,3',4',5'-hexachlorobiphenyl co-treated with Dibenzofurans, Polychlorinated co-treated with Polychlorinated Dibenzodioxins] results in increased expression of CYP1A1 mRNA; [Tetrachlorodibenzodioxin co-treated with 3,4,5,3',4',5'-hexachlorobiphenyl] results in increased expression of CYP1A1 proteinPMID:11339718 PMID:30744511
Cyp1a1increases expressionISOCYP1A1 (Homo sapiens)6480464CTD3,4,5,3',4',5'-hexachlorobiphenyl results in increased expression of CYP1A1 mRNAPMID:21781905
Cyp1a1multiple interactionsISOCyp1a1 (Mus musculus)6480464CTD[3,4,5,3',4',5'-hexachlorobiphenyl binds to and affects the localization of AHR protein] which results in increased expression of CYP1A1 mRNAPMID:21292640
Cyp1a1multiple interactionsISOCYP1A1 (Homo sapiens)6480464CTD3,4,5,3',4',5'-hexachlorobiphenyl promotes the reaction [AHR protein results in increased expression of CYP1A1 mRNA]PMID:21781905
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