Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
2,3,7,8-tetrachlorodibenzofuran results in increased expression of CYP1A1 mRNA; 2,3,7,8-tetrachlorodibenzofuran results in increased expression of CYP1A1 protein
2,3,7,8-tetrachlorodibenzofuran results in increased expression of CYP1A1 mRNA; 2,3,7,8-tetrachlorodibenzofuran results in increased expression of CYP1A1 protein
2,3,7,8-tetrachlorodibenzofuran promotes the reaction [AHR protein binds to CYP1A1 promoter]; AHR gene mutant form inhibits the reaction [2,3,7,8-tetrachlorodibenzofuran results in increased expression of CYP1A1 mRNA]; AHR protein promotes the reaction [2,3,7,8-tetrachlorodibenzofuran results in increased expression of CYP1A1 mRNA]
2,3,7,8-tetrachlorodibenzofuran promotes the reaction [AHR protein binds to CYP1A1 promoter]; 2,3,7,8-tetrachlorodibenzofuran promotes the reaction [AHR protein mutant form binds to CYP1A1 promoter]; 2,3,7,8-tetrachlorodibenzofuran promotes the reaction [ARNT protein binds to CYP1A1 promoter]; 2,3,7,8-tetrachlorodibenzofuran promotes the reaction [EP300 protein binds to CYP1A1 promoter]; [2,3,7,8-tetrachlorodibenzofuran co-treated with Calcium] results in increased expression of CYP1A1 mRNA; AHR protein mutant form inhibits the reaction [2,3,7,8-tetrachlorodibenzofuran results in increased expression of CYP1A1 mRNA]; AHR protein promotes the reaction [2,3,7,8-tetrachlorodibenzofuran results in increased activity of CYP1A1 protein]
