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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2458
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a1
Name: cytochrome P450, family 1, subfamily a, polypeptide 1
Acc ID: CHEBI:2979
Term: baicalein
Definition: A trihydroxyflavone with the hydroxy groups at positions C-5, -6 and -7.
Chemical ID: MESH:C006680
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a1decreases activityISOCYP1A1 (Homo sapiens)6480464CTDbaicalein results in decreased activity of CYP1A1 proteinPMID:21053930 PMID:21482471
Cyp1a1decreases expressionISOCYP1A1 (Homo sapiens)6480464CTDbaicalein results in decreased expression of CYP1A1 mRNAPMID:18451504
Cyp1a1increases chemical synthesisISOCYP1A1 (Homo sapiens)6480464CTDCYP1A1 protein results in increased chemical synthesis of baicaleinPMID:19666078
Cyp1a1increases expressionISOCYP1A1 (Homo sapiens)6480464CTDbaicalein results in increased expression of CYP1A1 proteinPMID:14644660
Cyp1a1multiple interactionsISOCYP1A1 (Homo sapiens)6480464CTD[CYP1A1 protein results in increased metabolism of chrysin] which results in increased chemical synthesis of baicalein; baicalein inhibits the reaction [benz(a)anthracene results in increased expression of CYP1A1 mRNA]; baicalein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]PMID:12224597 PMID:18451504 PMID:19666078
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