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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2458
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a1
Name: cytochrome P450, family 1, subfamily a, polypeptide 1
Acc ID: CHEBI:6076
Term: itraconazole
Definition: An N-arylpiperazine that is cis-ketoconazole in which the imidazol-1-yl group is replaced by a 1,2,4-triazol-1-yl group and in which the actyl group attached to the piperazine moiety is replaced by a p-[(+-)1-sec-butyl-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl]phenyl group. A potent P-glycoprotein and CYP3A4 inhibitor, it is used as an antifungal drug for the treatment of various fungal infections, including aspergillosis, blastomycosis, candidiasis, chromoblastomycosis, coccidioidomycosis, cryptococcosis, histoplasmosis, and sporotrichosis.
Chemical ID: MESH:D017964
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a1decreases activityISOCYP1A1 (Homo sapiens)6480464CTDItraconazole results in decreased activity of CYP1A1 proteinPMID:17283379
Cyp1a1increases expressionISOCyp1a1 (Mus musculus)6480464CTDItraconazole results in increased expression of CYP1A1 mRNAPMID:17283379
Cyp1a1increases expressionISOCYP1A1 (Homo sapiens)6480464CTDItraconazole results in increased expression of CYP1A1 mRNA; Itraconazole results in increased expression of CYP1A1 proteinPMID:17283379 PMID:28390928
Cyp1a1multiple interactionsISOCyp1a1 (Mus musculus)6480464CTDItraconazole results in increased expression of and results in increased activity of CYP1A1 proteinPMID:17283379
Cyp1a1multiple interactionsISOCYP1A1 (Homo sapiens)6480464CTDDactinomycin inhibits the reaction [Itraconazole results in increased expression of CYP1A1 mRNA]; Itraconazole results in increased expression of and results in increased activity of CYP1A1 proteinPMID:17283379
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