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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2458
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a1
Name: cytochrome P450, family 1, subfamily a, polypeptide 1
Acc ID: CHEBI:29866
Term: arsenite(3-)
Definition: An arsenite ion resulting from the removal of all three protons from the hydroxy groups of arsenous acid.
Chemical ID: MESH:C015001
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a1multiple interactionsEXP 6480464CTDarsenite inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [[AHR protein co-treated with ARNT protein] binds to CYP1A1 promoter]]; arsenite inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of and results in increased activity of CYP1A1 protein]; arsenite inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; Hemin inhibits the reaction [arsenite inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]]; tin mesoporphyrin inhibits the reaction [arsenite inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]]PMID:22159698
Cyp1a1increases expressionISOCyp1a1 (Mus musculus)6480464CTDarsenite results in increased expression of CYP1A1 mRNAPMID:15894712
Cyp1a1increases expressionISOCYP1A1 (Homo sapiens)6480464CTDarsenite results in increased expression of CYP1A1 mRNAPMID:31646340
Cyp1a1multiple interactionsISOCyp1a1 (Mus musculus)6480464CTDarsenite affects the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; arsenite inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; arsenite promotes the reaction [AHR protein binds to CYP1A1 promoter]PMID:15630080 PMID:15894712 PMID:23369756
Cyp1a1multiple interactionsISOCYP1A1 (Homo sapiens)6480464CTDarsenite inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]PMID:15630080
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