RGD Reference Report - Cytochrome P450 1A1 and manganese superoxide dismutase genes polymorphisms in ankylosing spondylitis. - Rat Genome Database

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Cytochrome P450 1A1 and manganese superoxide dismutase genes polymorphisms in ankylosing spondylitis.

Authors: Yen, JH  Tsai, WC  Chen, CJ  Lin, CH  Ou, TT  Hu, CJ  Liu, HW 
Citation: Yen JH, etal., Immunol Lett. 2003 Aug 5;88(2):113-6.
RGD ID: 1581252
Pubmed: PMID:12880680   (View Abstract at PubMed)

OBJECTIVES: To investigate the associations of cytochrome p450 1A1 (CYP1A1) and manganese superoxide dismutase (MnSOD) genes polymorphisms with the susceptibility to AS in Taiwan. METHODS: The polymorphisms of CYP1A1 and MnSOD genes were determined in 70 patients with ankylosing spondylitis (AS) and 93 healthy controls by polymerase chain reaction (PCR)/restriction fragment length polymorphisms (RFLP) methods. RESULTS: The genotype frequency of CYP1A1 4887C/A was significantly lower in patients with AS than in controls. The phenotype frequency of CYP1A1 4887A also tended to be decreased in patients with AS. There were no significant differences in the genotype, allele, and phenotype frequencies of MnSOD gene polymorphisms between patients with AS and controls. CONCLUSION: CYP1A1 4887A may be a protective factor for the development of AS in Taiwan. However, MnSOD gene polymorphisms are not associated with the susceptibility to AS.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
ankylosing spondylitis  IAGP 1581252DNA:polymorphism: :4887C>A (human)RGD 
ankylosing spondylitis  ISOCYP1A1 (Homo sapiens)1581252; 1581252DNA:polymorphism: :4887C>A (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cyp1a1  (cytochrome P450, family 1, subfamily a, polypeptide 1)

Genes (Mus musculus)
Cyp1a1  (cytochrome P450, family 1, subfamily a, polypeptide 1)

Genes (Homo sapiens)
CYP1A1  (cytochrome P450 family 1 subfamily A member 1)

Objects referenced in this article
Gene SOD2 superoxide dismutase 2 Homo sapiens
Gene Sod2 superoxide dismutase 2, mitochondrial Mus musculus
Gene Sod2 superoxide dismutase 2 Rattus norvegicus

Additional Information