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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2458
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a1
Name: cytochrome P450, family 1, subfamily a, polypeptide 1
Acc ID: CHEBI:16130
Term: DDT
Definition: A chlorophenylethane that is 1,1,1-trichloro-2,2-diphenylethane substituted by additional chloro substituents at positions 4 of the phenyl substituents. It is a commonly used organochlorine insecticide.
Chemical ID: MESH:D003634
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a1increases expressionEXP 6480464CTDDDT results in increased expression of CYP1A1 mRNAPMID:29477483
Cyp1a1multiple interactionsEXP 6480464CTD[Polychlorinated Biphenyls co-treated with DDT co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CYP1A1 mRNAPMID:16036770
Cyp1a1decreases expressionISOCYP1A1 (Homo sapiens)6480464CTDDDT results in decreased expression of CYP1A1 mRNAPMID:31521043
Cyp1a1increases expressionISOCyp1a1 (Mus musculus)6480464CTDDDT results in increased expression of CYP1A1 mRNAPMID:28263910
Cyp1a1increases expressionISOCYP1A1 (Homo sapiens)6480464CTDDDT results in increased expression of CYP1A1 mRNAPMID:20865247
Cyp1a1multiple interactionsISOCYP1A1 (Homo sapiens)6480464CTD[indole-3-carbinol co-treated with DDT] results in increased expression of CYP1A1 mRNA; aurapten inhibits the reaction [DDT results in increased expression of CYP1A1 mRNA]; nobiletin inhibits the reaction [DDT results in increased expression of CYP1A1 mRNA]PMID:17311112 PMID:20865247
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