GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cyp1a1 | multiple interactions | EXP | | 6480464 | CTD | Methoxychlor results in increased expression of and results in increased activity of CYP1A1 protein | PMID:12919727 | Cyp1a1 | decreases activity | ISO | Cyp1a1 (Mus musculus) | 6480464 | CTD | Methoxychlor results in decreased activity of CYP1A1 protein | PMID:15620088 PMID:18420780 | Cyp1a1 | decreases methylation | ISO | CYP1A1 (Homo sapiens) | 6480464 | CTD | CYP1A1 protein results in decreased methylation of Methoxychlor | PMID:12433799 | Cyp1a1 | multiple interactions | ISO | Cyp1a1 (Mus musculus) | 6480464 | CTD | Methoxychlor inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 enhancer]]; Methoxychlor inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; Methoxychlor inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] | PMID:17654248 | | ||||||||||||||||||||||
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