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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2458
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a1
Name: cytochrome P450, family 1, subfamily a, polypeptide 1
Acc ID: CHEBI:4917
Term: eugenol
Definition: A phenylpropanoid formally derived from guaiacol with an allyl chain substituted para to the hydroxy group. It is a major component of clove essential oil, and exhibits antibacterial, analgesic and antioxidant properties. It has been widely used in dentistry to treat toothache and pulpitis.
Chemical ID: MESH:D005054
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a1decreases activityISOCYP1A1 (Homo sapiens)6480464CTDEugenol results in decreased activity of CYP1A1 proteinPMID:17275817
Cyp1a1decreases expressionISOCYP1A1 (Homo sapiens)6480464CTDEugenol results in decreased expression of CYP1A1 mRNAPMID:20713136
Cyp1a1increases expressionISOCYP1A1 (Homo sapiens)6480464CTDEugenol results in increased expression of CYP1A1 mRNAPMID:22686307 PMID:29191726
Cyp1a1multiple interactionsISOCYP1A1 (Homo sapiens)6480464CTD[CYP1A1 protein co-treated with Copper] results in increased activity of Eugenol; Eugenol inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1A1 mRNA]; Eugenol inhibits the reaction [CYP1A1 protein results in increased metabolism of and results in increased activity of 9,10-Dimethyl-1,2-benzanthracene]; Eugenol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]PMID:15576237 PMID:17275817 PMID:29191726
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