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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2458
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a1
Name: cytochrome P450, family 1, subfamily a, polypeptide 1
Acc ID: CHEBI:34631
Term: chlorpyrifos
Definition: An organic thiophosphate that is O,O-diethyl hydrogen phosphorothioate in which the hydrogen of the hydroxy group has been replaced by a 3,5,6-trichloropyridin-2-yl group.
Chemical ID: MESH:D004390
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a1affects metabolic processingEXP 6480464CTDCYP1A1 protein affects the metabolism of ChlorpyrifosPMID:15587241
Cyp1a1decreases activityEXP 6480464CTDChlorpyrifos results in decreased activity of CYP1A1 proteinPMID:15587241
Cyp1a1decreases activityISOCyp1a1 (Mus musculus)6480464CTDChlorpyrifos results in decreased activity of CYP1A1 proteinPMID:15620088
Cyp1a1decreases activityISOCYP1A1 (Homo sapiens)6480464CTDChlorpyrifos results in decreased activity of CYP1A1 proteinPMID:20183062
Cyp1a1decreases expressionISOCYP1A1 (Homo sapiens)6480464CTDChlorpyrifos results in decreased expression of CYP1A1 proteinPMID:21784029
Cyp1a1increases expressionISOCyp1a1 (Mus musculus)6480464CTDChlorpyrifos results in increased expression of CYP1A1 mRNAPMID:37019170
Cyp1a1increases expressionISOCYP1A1 (Homo sapiens)6480464CTDChlorpyrifos results in increased expression of CYP1A1 mRNA; Chlorpyrifos results in increased expression of CYP1A1 proteinPMID:16190164 PMID:19326769 PMID:20035023 PMID:21784029 PMID:25233012 PMID:32171938 PMID:32194361 PMID:33011216
Cyp1a1multiple interactionsISOCyp1a1 (Mus musculus)6480464CTD[Atrazine co-treated with Chlorpyrifos co-treated with Endosulfan] results in increased expression of CYP1A1 mRNAPMID:22515965
Cyp1a1multiple interactionsISOCYP1A1 (Homo sapiens)6480464CTD2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Chlorpyrifos results in increased expression of CYP1A1 mRNA]PMID:25233012 PMID:32171938
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