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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2458
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a1
Name: cytochrome P450, family 1, subfamily a, polypeptide 1
Acc ID: CHEBI:4806
Term: (-)-epigallocatechin 3-gallate
Definition: A gallate ester obtained by the formal condensation of gallic acid with the (3R)-hydroxy group of (-)-epigallocatechin.
Chemical ID: MESH:C045651
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a1affects bindingEXP 6480464CTDepigallocatechin gallate binds to CYP1A1 proteinPMID:23010222
Cyp1a1increases activityEXP 6480464CTDepigallocatechin gallate results in increased activity of CYP1A1 proteinPMID:15895106
Cyp1a1decreases expressionISOCYP1A1 (Homo sapiens)6480464CTDepigallocatechin gallate results in decreased expression of CYP1A1 mRNAPMID:20816778
Cyp1a1multiple interactionsISOCYP1A1 (Homo sapiens)6480464CTDepigallocatechin gallate inhibits the reaction [[Tetrachlorodibenzodioxin binds to and results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA]; epigallocatechin gallate inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]PMID:11064004 PMID:14558788
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