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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2458
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a1
Name: cytochrome P450, family 1, subfamily a, polypeptide 1
Acc ID: CHEBI:42223
Term: emodin
Definition: A trihydroxyanthraquinone that is 9,10-anthraquinone which is substituted by hydroxy groups at positions 1, 3, and 8 and by a methyl group at position 6. It is present in the roots and barks of numerous plants (particularly rhubarb and buckthorn), moulds, and lichens. It is an active ingredient of various Chinese herbs.
Chemical ID: MESH:D004642
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a1decreases activityISOCYP1A1 (Homo sapiens)6480464CTDEmodin results in decreased activity of CYP1A1 proteinPMID:27633141
Cyp1a1increases expressionISOCYP1A1 (Homo sapiens)6480464CTDEmodin results in increased expression of CYP1A1 mRNA; Emodin results in increased expression of CYP1A1 proteinPMID:11502733 PMID:14644660
Cyp1a1multiple interactionsISOCYP1A1 (Homo sapiens)6480464CTDEmodin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]PMID:17012224
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