RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
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Igf2
insulin-like growth factor 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12087403
NCBI chr 1:197,814,409...197,831,802
Ensembl chr 1:197,814,410...197,823,018
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Prss8
serine protease 8
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:24722141
NCBI chr 1:182,536,229...182,540,745
Ensembl chr 1:182,536,229...182,540,815
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Spint2
serine peptidase inhibitor, Kunitz type, 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:24722141
NCBI chr 1:84,558,159...84,580,616
Ensembl chr 1:84,558,166...84,580,616
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Tnf
tumor necrosis factor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16007645
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Ager
advanced glycosylation end product-specific receptor
ISO
RGD
PMID:22578261
RGD:6767308
NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
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Fas
Fas cell surface death receptor
ISO
protein:increased expression:villous trophoblast
RGD
PMID:12700199
RGD:12904022
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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Il1a
interleukin 1 alpha
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21493953
NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
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Il6
interleukin 6
ISO
protein:increased expression:plasma protein:increased expression: cervicovaginal fluid : associated with Premature Birth;protein:increased expression:tracheal aspirate fluid:
RGD
PMID:15547537 PMID:25687566 PMID:25011638
RGD:5128667 , RGD:12792243 , RGD:12791291
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Lta
lymphotoxin alpha
severity
ISO
associated with Premature Birth;DNA:SNP:promoter:250G>A (human)
RGD
PMID:15128916
RGD:12904055
NCBI chr20:3,618,853...3,621,324
Ensembl chr20:3,618,853...3,620,859
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Mbl2
mannose binding lectin 2
susceptibility
ISO
DNA:polymorphism:exon:p.G54D(human)
RGD
PMID:15723707
RGD:12910932
NCBI chr 1:228,016,439...228,024,736
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Mmp9
matrix metallopeptidase 9
severity
ISO
protein:increased expression:respiratory system fluid/secretion
RGD
PMID:12712078
RGD:13204828
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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Tgfb1
transforming growth factor, beta 1
severity
ISO
protein:increased expression:amniotic fluid
RGD
PMID:19332995
RGD:4145137
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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Tnf
tumor necrosis factor
no_association severity
ISO
associated with Premature Birth;DNA:SNP:promoter:c.-308 G>A (human) associated with Premature Birth;DNA:SNP:promoter:c.-238G>A (human)
RGD
PMID:15128916 PMID:15128916
RGD:12904055 , RGD:12904055
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Trem1
triggering receptor expressed on myeloid cells 1
ISO
associated with Premature Obstetric Labor;protein:increased expression:amniotic fluid:
RGD
PMID:19591072
RGD:127229904
NCBI chr 9:12,763,819...12,779,285
Ensembl chr 9:12,763,819...12,779,203
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Fgf8
fibroblast growth factor 8
ISO
testicular germ cell neoplasms
RGD
PMID:11764380
RGD:2289339
NCBI chr 1:244,584,477...244,590,578
Ensembl chr 1:244,584,652...244,590,359
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Igf2
insulin-like growth factor 2
disease_progression
ISO
RGD
PMID:17556377
RGD:2290454
NCBI chr 1:197,814,409...197,831,802
Ensembl chr 1:197,814,410...197,823,018
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Insr
insulin receptor
disease_progression
ISO
RGD
PMID:17556377
RGD:2290454
NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883
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Pdgfb
platelet derived growth factor subunit B
ISO
mRNA:increased expression:mononuclear cytotrophoblast cell
RGD
PMID:8504434
RGD:2292200
NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
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Pdgfrb
platelet derived growth factor receptor beta
ISO
mRNA:increased expression:mononuclear cytotrophoblast cell
RGD
PMID:8504434
RGD:2292200
NCBI chr18:54,499,962...54,538,840
Ensembl chr18:54,499,964...54,538,843
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Timp3
TIMP metallopeptidase inhibitor 3
ISO
DNA, protein:hypermethylation, decreased expression:promoter, placenta
RGD
PMID:15507671
RGD:2290418
NCBI chr 7:17,520,827...17,571,850
Ensembl chr 7:17,521,919...17,571,839
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Hspg2
heparan sulfate proteoglycan 2
ISO
ClinVar Annotator: match by term: Lethal Kniest-like syndrome
ClinVar
PMID:9536098 PMID:11279527 PMID:16199547 PMID:16927315 PMID:17576681 PMID:20542149 PMID:23836246 PMID:24011702 PMID:24088041 PMID:24781210 PMID:25504735 PMID:25741868 PMID:25741881 PMID:25803036 PMID:26467025 PMID:26508570 PMID:26633545 PMID:28242392 PMID:28492532 PMID:29271572 PMID:29620724 PMID:29901129 PMID:30362252 PMID:31127727 PMID:34244600 PMID:34906502 PMID:35982159 More...
NCBI chr 5:149,677,437...149,778,594
Ensembl chr 5:149,677,476...149,778,594
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Ldlrad2
low density lipoprotein receptor class A domain containing 2
ISO
ClinVar Annotator: match by term: Lethal Kniest-like syndrome
ClinVar
PMID:25504735 PMID:25741868 PMID:26467025 PMID:28492532
NCBI chr 5:149,778,795...149,788,335
Ensembl chr 5:149,779,675...149,787,140
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Agt
angiotensinogen
ISO
ClinVar Annotator: match by term: Anhydramnios
ClinVar
PMID:25741868 PMID:35005812
NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
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Dnajb11
DnaJ heat shock protein family (Hsp40) member B11
ISO
ClinVar Annotator: match by term: anhydramnios
ClinVar
PMID:25741868 PMID:35005812
NCBI chr11:78,151,750...78,168,259
Ensembl chr11:78,150,429...78,180,407
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Inf2
inverted formin 2
ISO
ClinVar Annotator: match by term: Oligohydramnios
ClinVar
PMID:25741868
NCBI chr 6:131,649,162...131,675,944
Ensembl chr 6:131,649,211...131,675,941
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Nphp3
nephrocystin 3
ISO
ClinVar Annotator: match by term: anhydramnios
ClinVar
PMID:25741868 PMID:35005812
NCBI chr 8:104,621,908...104,662,383
Ensembl chr 8:104,621,864...104,662,383
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Pdgfa
platelet derived growth factor subunit A
IEP
mRNA, protein:increased expression:lung
RGD
PMID:17519529
RGD:2292203
NCBI chr12:15,645,549...15,667,056
Ensembl chr12:15,645,541...15,666,497
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Pdgfb
platelet derived growth factor subunit B
IEP
mRNA, protein:increased expression:lung
RGD
PMID:17519529
RGD:2292203
NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
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Pdgfra
platelet derived growth factor receptor alpha
IEP
mRNA:increased expression:lung
RGD
PMID:17519529
RGD:2292203
NCBI chr14:33,005,838...33,054,347
Ensembl chr14:33,005,839...33,054,335
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Pdgfrb
platelet derived growth factor receptor beta
IEP
mRNA:increased expression:lung
RGD
PMID:17519529
RGD:2292203
NCBI chr18:54,499,962...54,538,840
Ensembl chr18:54,499,964...54,538,843
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Pdpn
podoplanin
IEP
mRNA, protein:decreased expression:lung
RGD
PMID:11839536
RGD:2292243
NCBI chr 5:155,601,691...155,635,656
Ensembl chr 5:155,601,691...155,635,656
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Pkd1
polycystin 1, transient receptor potential channel interacting
ISO
ClinVar Annotator: match by term: anhydramnios
ClinVar
PMID:25741868 PMID:35005812
NCBI chr10:13,573,779...13,621,138
Ensembl chr10:13,573,021...13,621,128
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Pkd2
polycystin 2, transient receptor potential cation channel
ISO
ClinVar Annotator: match by term: anhydramnios
ClinVar
PMID:25741868 PMID:35005812
NCBI chr14:5,237,135...5,280,455
Ensembl chr14:5,237,135...5,280,825
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Pkhd1
PKHD1 ciliary IPT domain containing fibrocystin/polyductin
ISO
ClinVar Annotator: match by term: Oligohydramnios | ClinVar Annotator: match by term: anhydramnios
ClinVar
PMID:11898128 PMID:11919560 PMID:12506140 PMID:12846734 PMID:12874454 PMID:15108277 PMID:15108281 PMID:15696446 PMID:15706593 PMID:15805161 PMID:16133180 PMID:16199545 PMID:19914852 PMID:20413436 PMID:21274727 PMID:25124979 PMID:25741868 PMID:26695994 PMID:27225849 PMID:28375157 PMID:28492532 PMID:30773290 PMID:32799815 PMID:33532864 PMID:35005812 More...
NCBI chr 9:22,547,396...23,037,443
Ensembl chr 9:22,549,513...23,037,381
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Tmem67
transmembrane protein 67
ISO
ClinVar Annotator: match by term: Oligohydramnios | ClinVar Annotator: match by term: anhydramnios
ClinVar
PMID:19466712 PMID:19508969 PMID:19540516 PMID:19574260 PMID:20607301 PMID:21068128 PMID:21866095 PMID:23559409 PMID:25741868 PMID:26035863 PMID:26092869 PMID:28492532 PMID:35005812 More...
NCBI chr 5:25,536,458...25,589,378
Ensembl chr 5:25,536,458...25,589,334
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Bhmt
betaine-homocysteine S-methyltransferase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17376725
NCBI chr 2:24,859,871...24,879,449
Ensembl chr 2:24,859,873...24,879,742
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Mthfd1
methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:15633187
NCBI chr 6:94,977,862...95,045,375
Ensembl chr 6:94,977,862...95,045,372
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Nos3
nitric oxide synthase 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:11354626
NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
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Proc
protein C, inactivator of coagulation factors Va and VIIIa
susceptibility
ISO
RGD
PMID:9855597
RGD:11564329
NCBI chr18:23,764,367...23,774,816
Ensembl chr18:23,764,368...23,775,133
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Agtr1a
angiotensin II receptor, type 1a
IEP
mRNA, protein:increased expression:placenta
RGD
PMID:20621762
RGD:5147460
NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
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Cyp19a1
cytochrome P450, family 19, subfamily a, polypeptide 1
IEP
mRNA, protein:altered expression:hippocampus (rat)
RGD
PMID:20662593
RGD:4890445
NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758
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Emp2
epithelial membrane protein 2
ISS
MouseDO
NCBI chr10:5,360,073...5,394,734
Ensembl chr10:5,360,073...5,394,733
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Epo
erythropoietin
treatment
ISO
RGD
PMID:20809703
RGD:10400897
NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
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Gjb3
gap junction protein, beta 3
ISO
RGD
PMID:11237463
RGD:12436730
NCBI chr 5:139,649,227...139,654,970
Ensembl chr 5:139,649,195...139,654,980
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Grin1
glutamate ionotropic receptor NMDA type subunit 1
IEP
mRNA, protein:altered expression:hippocampus (rat)
RGD
PMID:19144756
RGD:2326049
NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603
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Grin2a
glutamate ionotropic receptor NMDA type subunit 2A
IEP
protein:decreased expression:hippocampus (rat)
RGD
PMID:19144756
RGD:2326049
NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637
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Grin2b
glutamate ionotropic receptor NMDA type subunit 2B
IEP
protein:increased expression:hippocampus (rat)
RGD
PMID:19144756
RGD:2326049
NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279
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Itga2
integrin subunit alpha 2
IEP
mRNA:decreased expression:placenta (rat)
RGD
PMID:20621762
RGD:5147460
NCBI chr 2:46,520,345...46,621,487
Ensembl chr 2:46,523,948...46,621,481
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Pdx1
pancreatic and duodenal homeobox 1
IEP
mRNA:increased expression:placenta (rat)
RGD
PMID:17893880
RGD:2311215
NCBI chr12:7,757,865...7,763,064
Ensembl chr12:7,757,865...7,763,064
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Ppargc1a
PPARG coactivator 1 alpha
IEP
mRNA, protein:decreased expression:gastrocnemius muscle (rat)
RGD
PMID:18319353
RGD:10059693
NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
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Serpine1
serpin family E member 1
ISO
protein:increased expression:plasma:
RGD
PMID:26903689
RGD:11557202
NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
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Gpc3
glypican 3
ISO
protein:increased expression:placenta, trophoblast cells (human)
RGD
PMID:20868507
RGD:243065141
NCBI chr X:131,868,986...132,236,824
Ensembl chr X:131,868,990...132,236,798
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Abcc8
ATP binding cassette subfamily C member 8
ISO
ClinVar Annotator: match by term: Polyhydramnios
ClinVar
PMID:16613899 PMID:16885549 PMID:18025408 PMID:18981553 PMID:21989597 PMID:25741868 PMID:27538677 PMID:32027066 PMID:32792356 More...
NCBI chr 1:96,598,568...96,679,563
Ensembl chr 1:96,598,647...96,679,510
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Gldn
gliomedin
ISO
ClinVar Annotator: match by term: Polyhydramnios
ClinVar
PMID:25741868 PMID:27616481 PMID:28726266 PMID:31680349
NCBI chr 8:54,679,015...54,723,198
Ensembl chr 8:54,679,119...54,723,196
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Hyls1
HYLS1, centriolar and ciliogenesis associated
ISO
ClinVar Annotator: match by term: Polyhydramnios
ClinVar
PMID:25741868 PMID:27055666 PMID:31680349
NCBI chr 8:33,912,692...33,921,760
Ensembl chr 8:33,912,692...33,921,760
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Igf2
insulin-like growth factor 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:9349812
NCBI chr 1:197,814,409...197,831,802
Ensembl chr 1:197,814,410...197,823,018
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Kcnq1
potassium voltage-gated channel subfamily Q member 1
ISO
ClinVar Annotator: match by term: Polyhydramnios
ClinVar
PMID:1984130 PMID:2654361 PMID:15781747 PMID:15840476 PMID:19716085 PMID:19841300 PMID:22581653 PMID:22949429 PMID:23392653 PMID:23631430 PMID:24033266 PMID:24947509 PMID:25741868 PMID:25854863 PMID:26546361 PMID:26669661 PMID:27831900 PMID:28492532 PMID:30755392 PMID:31447099 PMID:32893267 PMID:34135346 PMID:34404389 PMID:34798354 PMID:35352813 PMID:36102233 More...
NCBI chr 1:198,291,711...198,624,683
Ensembl chr 1:198,291,766...198,624,669
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Lnpep
leucyl and cystinyl aminopeptidase
ISO
associated with Diabetes Mellitus
RGD
PMID:1789335
RGD:2311543
NCBI chr 1:58,258,642...58,355,532
Ensembl chr 1:58,258,642...58,354,544
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Mtm1
myotubularin 1
ISO
ClinVar Annotator: match by term: Polyhydramnios
ClinVar
PMID:25741868
NCBI chr 6:488,923...506,882
Ensembl chr 6:488,969...506,860
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Piezo1
piezo-type mechanosensitive ion channel component 1
ISO
ClinVar Annotator: match by term: Polyhydramnios
ClinVar
PMID:25741868 PMID:28492532 PMID:30244526 PMID:31680349
NCBI chr19:50,544,580...50,606,812
Ensembl chr19:50,544,582...50,606,501
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Pus3
pseudouridine synthase 3
ISO
ClinVar Annotator: match by term: Polyhydramnios
ClinVar
PMID:25741868 PMID:27055666 PMID:31680349
NCBI chr 8:33,910,461...33,918,716
Ensembl chr 8:33,911,357...33,918,714
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Slc26a3
solute carrier family 26 member 3
ISO
ClinVar Annotator: match by term: Polyhydramnios
ClinVar
PMID:9718329 PMID:21394828 PMID:25741868 PMID:28492532 PMID:31680349 PMID:33191723 PMID:34503561 More...
NCBI chr 6:48,023,892...48,064,829
Ensembl chr 6:48,023,892...48,064,772
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Strada
STE20 related adaptor alpha
ISO
ClinVar Annotator: match by term: PMSE SYNDROME | ClinVar Annotator: match by term: Polyhydramnios, megalencephaly, and symptomatic epilepsy CTD Direct Evidence: marker/mechanism
OMIM ClinVar CTD
PMID:9536098 PMID:16199547 PMID:17522105 PMID:17576681 PMID:20424326 PMID:25741868 PMID:27170158 PMID:28492532 PMID:29358611 PMID:33605605 PMID:35830182 More...
NCBI chr10:91,094,849...91,123,890
Ensembl chr10:91,094,687...91,123,830
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