RGD Reference Report - Predominant expression of fibroblast growth factor (FGF) 8, FGF4, and FGF receptor 1 in nonseminomatous and highly proliferative components of testicular germ cell tumors. - Rat Genome Database

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Predominant expression of fibroblast growth factor (FGF) 8, FGF4, and FGF receptor 1 in nonseminomatous and highly proliferative components of testicular germ cell tumors.

Authors: Suzuki, K  Tokue, A  Kamiakito, T  Kuriki, K  Saito, K  Tanaka, A 
Citation: Suzuki K, etal., Virchows Arch. 2001 Nov;439(5):616-21.
RGD ID: 2289339
Pubmed: PMID:11764380   (View Abstract at PubMed)

Nonseminomatous components within testicular germ cell tumors affect patient prognosis to varying degrees. These components are well known to mimic early embryonic totipotential tissues. Prompted by the recent observation that fibroblast growth factor (FGF) 8, FGF4, and FGF receptor (FGFR) 1 are required for the growth of early postimplantational embryonic tissues, we investigated the expressions of FGF8, FGF4, and FGFRI in surgically resected specimens of primary testicular germ cell tumors using an immunohistochemical method. All cases of embryonal carcinoma (14 cases), yolk sac tumor (3 cases), and choriocarcinoma (3 cases) showed positive immunostaining for FGF8, FGF4, and FGFR1. In contrast, out of 13 cases of seminoma, immunostaining was negative for FGF8, FGF4, and FGFR1 in 8 cases (61.5%), 6 cases (46.1%), and 7 cases (53.8%), respectively. In 7 cases of mature and immature teratoma, most areas showed negative immunostaining. In addition, the Ki-67 labeling index showed extremely high mitogenic activity in embryonal carcinoma, yolk sac tumor, and choriocarcinoma, which are precisely the carcinomas with the highest expressions of FGF8, FGF4, and FGFR1. It is in keeping with the immunohistochemical result that murine teratocarcinoma P19 cells were shown to express FGF8, FGF4, and FGFRI only under undifferentiated growth conditions. Taken together, these findings confirm the involvement of FGF8, FGF4, and FGFR1 in highly proliferative conditions of nonseminomatous germ cell tumors.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
choriocarcinoma  IEP 2289339protein:increased expression:testicular germ cell neoplasmsRGD 
choriocarcinoma  ISOFGF8 (Homo sapiens)2289339; 2289339testicular germ cell neoplasmsRGD 
embryonal carcinoma  IEP 2289339protein:increased expression:testicular germ cell neoplasmsRGD 
embryonal carcinoma  ISOFGF8 (Homo sapiens)2289339; 2289339testicular germ cell neoplasmsRGD 
endodermal sinus tumor  IEP 2289339protein:increased expression:testicular germ cell neoplasmsRGD 
endodermal sinus tumor  ISOFGF8 (Homo sapiens)2289339; 2289339testicular germ cell neoplasmsRGD 

Objects Annotated

Genes (Rattus norvegicus)
Fgf8  (fibroblast growth factor 8)

Genes (Mus musculus)
Fgf8  (fibroblast growth factor 8)

Genes (Homo sapiens)
FGF8  (fibroblast growth factor 8)


Additional Information