Piezo1 (piezo-type mechanosensitive ion channel component 1) - Rat Genome Database

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Gene: Piezo1 (piezo-type mechanosensitive ion channel component 1) Rattus norvegicus
Analyze
Symbol: Piezo1
Name: piezo-type mechanosensitive ion channel component 1
RGD ID: 1308822
Description: Predicted to have cation channel activity; identical protein binding activity; and mechanosensitive ion channel activity. Predicted to be involved in several processes, including cellular response to mechanical stimulus; positive regulation of cell-cell adhesion mediated by integrin; and positive regulation of integrin activation. Predicted to localize to endoplasmic reticulum and plasma membrane. Human ortholog(s) of this gene implicated in dehydrated hereditary stomatocytosis 1 and hereditary lymphedema. Orthologous to human PIEZO1 (piezo type mechanosensitive ion channel component 1); INTERACTS WITH (+)-schisandrin B; acetamide; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Fam38a; family with sequence similarity 38, member A; LOC361430; membrane protein induced by beta-amyloid treatment; Mib
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21950,544,580 - 50,606,812 (-)NCBI
Rnor_6.0 Ensembl1955,305,496 - 55,367,353 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01955,305,494 - 55,367,680 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01966,014,939 - 66,075,869 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41952,770,967 - 52,834,347 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11952,776,154 - 52,852,837 (-)NCBI
Celera1949,784,059 - 49,845,831 (-)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:8889548   PMID:16854388   PMID:20016066   PMID:20813920   PMID:22343900   PMID:26390154   PMID:27756599   PMID:29261642   PMID:29469092   PMID:29735991   PMID:30004235   PMID:30948157  
PMID:31727906  


Genomics

Comparative Map Data
Piezo1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21950,544,580 - 50,606,812 (-)NCBI
Rnor_6.0 Ensembl1955,305,496 - 55,367,353 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01955,305,494 - 55,367,680 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01966,014,939 - 66,075,869 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41952,770,967 - 52,834,347 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11952,776,154 - 52,852,837 (-)NCBI
Celera1949,784,059 - 49,845,831 (-)NCBICelera
Cytogenetic Map19q12NCBI
PIEZO1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1688,715,338 - 88,785,220 (-)EnsemblGRCh38hg38GRCh38
GRCh381688,715,338 - 88,785,220 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371688,781,746 - 88,851,628 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361687,309,247 - 87,351,726 (-)NCBINCBI36hg18NCBI36
Build 341687,309,255 - 87,330,160NCBI
Celera1673,852,958 - 73,920,009 (-)NCBI
Cytogenetic Map16q24.3NCBI
HuRef1674,477,633 - 74,549,500 (-)NCBIHuRef
CHM1_11690,193,016 - 90,262,796 (-)NCBICHM1_1
Piezo1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398123,208,437 - 123,278,068 (-)NCBIGRCm39mm39
GRCm39 Ensembl8123,208,437 - 123,278,068 (-)Ensembl
GRCm388122,481,698 - 122,551,329 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8122,481,698 - 122,551,329 (-)EnsemblGRCm38mm10GRCm38
MGSCv378125,005,598 - 125,075,229 (-)NCBIGRCm37mm9NCBIm37
MGSCv368125,372,380 - 125,437,419 (-)NCBImm8
Celera8126,710,730 - 126,780,760 (-)NCBICelera
Cytogenetic Map8E1NCBI
Piezo1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555412,618,438 - 2,643,771 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555412,618,167 - 2,655,349 (-)NCBIChiLan1.0ChiLan1.0
PIEZO1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11689,088,323 - 89,143,463 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1689,088,323 - 89,125,068 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01669,428,461 - 69,498,454 (-)NCBIMhudiblu_PPA_v0panPan3
PIEZO1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1564,584,153 - 64,640,423 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl564,570,035 - 64,640,375 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha564,595,638 - 64,651,743 (+)NCBI
ROS_Cfam_1.0564,804,439 - 64,860,493 (+)NCBI
UMICH_Zoey_3.1564,830,683 - 64,886,668 (+)NCBI
UNSW_CanFamBas_1.0564,662,209 - 64,718,234 (+)NCBI
UU_Cfam_GSD_1.0565,068,355 - 65,124,410 (+)NCBI
Piezo1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934925,178,700 - 25,226,974 (+)NCBI
SpeTri2.0NW_004936641932,291 - 980,440 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PIEZO1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6915,365 - 967,106 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16914,480 - 967,113 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2654,610,402 - 54,612,349 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PIEZO1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1574,100,675 - 74,167,194 (-)NCBI
ChlSab1.1 Ensembl574,100,929 - 74,134,167 (-)Ensembl
Piezo1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624746821,651 - 871,481 (+)NCBI

Position Markers
RH131577  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21950,544,232 - 50,544,563 (+)MAPPER
Rnor_6.01955,305,147 - 55,305,477NCBIRnor6.0
Rnor_5.01966,014,592 - 66,014,922UniSTSRnor5.0
RGSC_v3.41952,770,620 - 52,770,950UniSTSRGSC3.4
Celera1949,783,712 - 49,784,042UniSTS
RH 3.4 Map19701.3UniSTS
Cytogenetic Map19q12UniSTS
RH141716  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21950,544,757 - 50,544,940 (+)MAPPER
Rnor_6.01955,305,672 - 55,305,854NCBIRnor6.0
Rnor_5.01966,015,117 - 66,015,299UniSTSRnor5.0
RGSC_v3.41952,771,145 - 52,771,327UniSTSRGSC3.4
Celera1949,784,237 - 49,784,419UniSTS
RH 3.4 Map19698.5UniSTS
Cytogenetic Map19q12UniSTS
MARC_12079-12080:1004624307:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21950,554,920 - 50,555,531 (+)MAPPER
Rnor_6.01955,315,834 - 55,316,444NCBIRnor6.0
Rnor_5.01966,025,279 - 66,025,889UniSTSRnor5.0
RGSC_v3.41952,781,307 - 52,781,917UniSTSRGSC3.4
Celera1949,794,236 - 49,794,846UniSTS
Cytogenetic Map19q12UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19243296362275575Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19650676160220581Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191899398262275575Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191917749562275575Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)192140778762275575Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192481825762275575Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)193299439262275575Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum insulin level (CMO:0000358)193791679960220451Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)193791679960220451Rat
5135224Leukc1Leukocyte quantity QTL 1eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)194883071260220581Rat
2313395Anxrr26Anxiety related response QTL 26aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)195473521758072143Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:89
Count of miRNA genes:72
Interacting mature miRNAs:83
Transcripts:ENSRNOT00000058332
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 26 28 22 12 22 4 21 30 11
Low 2 17 29 19 7 19 8 11 70 14 10 8
Below cutoff 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000091139   ⟹   ENSRNOP00000069995
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1955,305,496 - 55,367,353 (-)Ensembl
RefSeq Acc Id: NM_001077200   ⟹   NP_001070668
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21950,544,580 - 50,606,501 (-)NCBI
Rnor_6.01955,305,494 - 55,367,353 (-)NCBI
Rnor_5.01966,014,939 - 66,075,869 (-)NCBI
RGSC_v3.41952,770,967 - 52,834,347 (-)RGD
Celera1949,784,059 - 49,845,831 (-)RGD
Sequence:
RefSeq Acc Id: XM_008772626   ⟹   XP_008770848
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21950,544,580 - 50,606,803 (-)NCBI
Rnor_6.01955,305,494 - 55,367,680 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008772627   ⟹   XP_008770849
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21950,544,580 - 50,606,803 (-)NCBI
Rnor_6.01955,305,494 - 55,367,680 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017601325   ⟹   XP_017456814
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21950,544,580 - 50,570,977 (-)NCBI
Rnor_6.01955,305,494 - 55,360,135 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039097875   ⟹   XP_038953803
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21950,544,580 - 50,573,720 (-)NCBI
RefSeq Acc Id: XM_039097876   ⟹   XP_038953804
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21950,544,580 - 50,573,720 (-)NCBI
RefSeq Acc Id: XR_005496668
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21950,548,538 - 50,606,812 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_001070668   ⟸   NM_001077200
- UniProtKB: Q0KL00 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008770849   ⟸   XM_008772627
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_008770848   ⟸   XM_008772626
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017456814   ⟸   XM_017601325
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSRNOP00000069995   ⟸   ENSRNOT00000091139
RefSeq Acc Id: XP_038953804   ⟸   XM_039097876
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038953803   ⟸   XM_039097875
- Peptide Label: isoform X3
Protein Domains
PIEZO   Piezo_RRas_bdg

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701209
Promoter ID:EPDNEW_R11733
Type:single initiation site
Name:Piezo1_1
Description:piezo-type mechanosensitive ion channel component 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01955,367,347 - 55,367,407EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308822 AgrOrtholog
Ensembl Genes ENSRNOG00000056786 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000069995 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000091139 ENTREZGENE, UniProtKB/TrEMBL
InterPro Piezo UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Piezo_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Piezo_RRas-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:361430 UniProtKB/Swiss-Prot
NCBI Gene 361430 ENTREZGENE
PANTHER PTHR13167 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PIEZO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Piezo_RRas_bdg UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Piezo1 PhenoGen
UniProt A0A0G2JWS3_RAT UniProtKB/TrEMBL
  PIEZ1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-07-16 Piezo1  piezo-type mechanosensitive ion channel component 1  Fam38a  family with sequence similarity 38, member A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Fam38a  family with sequence similarity 38, member A   Fam38a_predicted  family with sequence similarity 38, member A (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Fam38a_predicted  family with sequence similarity 38, member A (predicted)      Symbol and Name status set to approved 70820 APPROVED