RGD Reference Report - Interleukin-6, interleukin-8, and soluble tumor necrosis factor receptor-I in the cord blood as predictors of chronic lung disease in premature infants.

General

Interleukin-6, interleukin-8, and soluble tumor necrosis factor receptor-I in the cord blood as predictors of chronic lung disease in premature infants.
Authors:	An, H Nishimaki, S Ohyama, M Haruki, A Naruto, T Kobayashi, N Sugai, T Kobayashi, Y Mori, M Seki, K Yokota, S
Citation:	An H, etal., Am J Obstet Gynecol. 2004 Nov;191(5):1649-54.
RGD ID:	5128667
Pubmed:	PMID:15547537 (View Abstract at PubMed)
DOI:	DOI:10.1016/j.ajog.2004.04.014 (Journal Full-text)
OBJECTIVES: In order to predict the late-development of chronic lung disease of prematurity (CLD), cytokines in the cord blood were assessed in this study. STUDY DESIGN: Eighteen premature infants with CLD were enrolled. Cord blood plasma levels of cytokines of these infants and 12 control infants without CLD were measured including interleukin (IL)-1beta, IL-2, IL-4, IL-6, IL-8, IL-10, interferon (IFN)-gamma, tumor necrosis factor (TNF)-alpha, soluble TNF receptor-I, and soluble IL-6 receptor using a cytometric bead array and an enzyme-linked immunosorbent assay. RESULTS: The cord blood IL-6, IL-8, and sTNFR-I levels were significantly elevated in CLD infants compared with those in control (P < .05). IL-1beta, IL-2, IL-4, IL-10, and IFN-gamma were undetectable in both groups. CLD infants with maternal chorioamnionitis had higher IL-6 than those without chorioamnionitis (P < .01). In CLD infants, IL-6 was higher in the infants who required prolonged oxygen therapy (P < .05). CONCLUSION: Elevated inflammatory cytokines in the cord blood are associated with the progression to CLD.

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Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
chorioamnionitis		IEP		5128667	protein:increased expression:plasma	RGD
chorioamnionitis		ISO	IL6 (Homo sapiens)	5128667; 5128667	protein:increased expression:plasma	RGD
lung disease		IEP		5128667	protein:increased expression:plasma	RGD
lung disease		ISO	IL6 (Homo sapiens)	5128667; 5128667	protein:increased expression:plasma	RGD

Objects Annotated

Genes (Rattus norvegicus)

Il6 (interleukin 6)

Genes (Mus musculus)

Il6 (interleukin 6)

Genes (Homo sapiens)

IL6 (interleukin 6)

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Interleukin-6, interleukin-8, and soluble tumor necrosis factor receptor-I in the cord blood as predictors of chronic lung disease in premature infants.