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G |
Adipoq |
adiponectin, C1Q and collagen domain containing |
multiple interactions increases expression |
ISO |
2-chloro-5-nitrobenzanilide inhibits the reaction [shogaol results in increased expression of ADIPOQ mRNA]; shogaol inhibits the reaction [TNF protein results in decreased expression of and results in decreased secretion of ADIPOQ protein] |
CTD |
PMID:18577375 |
|
NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
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G |
Akr1b10 |
aldo-keto reductase family 1 member B10 |
increases expression |
ISO |
shogaol metabolite results in increased expression of AKR1B10 protein; shogaol results in increased expression of AKR1B10 mRNA; shogaol results in increased expression of AKR1B10 protein |
CTD |
PMID:25148906 |
|
NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852
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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions affects phosphorylation |
ISO |
shogaol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of AKT1 protein] AKT activator SC79 affects the reaction [shogaol affects the phosphorylation of AKT1 protein] |
CTD |
PMID:18683823 PMID:36341865 |
|
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression affects folding multiple interactions |
ISO |
shogaol results in increased expression of BAX protein shogaol affects the folding of BAX protein shogaol promotes the reaction [BAX protein binds to BAX protein binds to BAX protein]; shogaol promotes the reaction [BAX protein binds to BAX protein] |
CTD |
PMID:18384088 PMID:25619640 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression |
ISO |
shogaol results in decreased expression of BCL2 protein |
CTD |
PMID:18384088 |
|
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Bcl2l1 |
Bcl2-like 1 |
decreases expression |
ISO |
shogaol results in decreased expression of BCL2L1 protein |
CTD |
PMID:18384088 |
|
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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G |
Bdnf |
brain-derived neurotrophic factor |
multiple interactions increases expression |
ISO |
[shogaol co-treated with Hydrogen Peroxide] results in increased expression of BDNF mRNA; [shogaol co-treated with Hydrogen Peroxide] results in increased expression of BDNF protein; shogaol inhibits the reaction [Hydrogen Peroxide results in decreased expression of BDNF mRNA] [shogaol results in increased expression of BDNF protein] which results in increased expression of CHAT protein; [shogaol results in increased expression of BDNF protein] which results in increased expression of SLC5A7 protein |
CTD |
PMID:22381256 |
|
NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
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|
G |
Casp3 |
caspase 3 |
multiple interactions |
ISO |
[shogaol co-treated with TNFSF10 protein] results in increased cleavage of CASP3 protein; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [[shogaol co-treated with TNFSF10 protein] results in increased cleavage of CASP3 protein]; shogaol results in increased cleavage of and results in increased activity of CASP3 protein |
CTD |
PMID:18384088 PMID:25619640 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp9 |
caspase 9 |
multiple interactions |
ISO |
shogaol results in increased cleavage of and results in increased activity of CASP9 protein |
CTD |
PMID:18384088 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Cat |
catalase |
decreases expression |
ISO |
shogaol results in decreased expression of CAT mRNA; shogaol results in decreased expression of CAT protein |
CTD |
PMID:36341865 |
|
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Cdh1 |
cadherin 1 |
increases expression multiple interactions |
ISO |
shogaol results in increased expression of CDH1 mRNA; shogaol results in increased expression of CDH1 protein ferrostatin-1 inhibits the reaction [shogaol results in increased expression of CDH1 protein] |
CTD |
PMID:36341865 |
|
NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
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G |
Cdh2 |
cadherin 2 |
decreases expression affects expression |
ISO |
shogaol results in decreased expression of CDH2 protein shogaol affects the expression of CDH2 mRNA |
CTD |
PMID:36341865 |
|
NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
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G |
Cflar |
CASP8 and FADD-like apoptosis regulator |
multiple interactions decreases expression |
ISO |
Acetylcysteine inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in decreased expression of CFLAR protein modified form]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [shogaol results in decreased expression of CFLAR protein modified form]; CFLAR protein modified form inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; S-ethyl glutathione inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in decreased expression of CFLAR protein modified form]]; shogaol promotes the reaction [Cycloheximide results in decreased expression of CFLAR protein modified form]; shogaol promotes the reaction [TNFSF10 protein results in decreased expression of CFLAR protein modified form] |
CTD |
PMID:25619640 |
|
NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034
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G |
Chat |
choline O-acetyltransferase |
multiple interactions increases expression |
ISO |
[shogaol co-treated with Hydrogen Peroxide] results in increased expression of CHAT protein; shogaol inhibits the reaction [Hydrogen Peroxide results in decreased expression of CHAT protein]; staurosporine aglycone inhibits the reaction [[shogaol co-treated with Hydrogen Peroxide] results in increased expression of CHAT protein] [shogaol results in increased expression of BDNF protein] which results in increased expression of CHAT protein; shogaol results in increased expression of CHAT protein |
CTD |
PMID:22381256 |
|
NCBI chr16:7,657,362...7,717,093
Ensembl chr16:7,657,362...7,717,093
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G |
Chuk |
component of inhibitor of nuclear factor kappa B kinase complex |
multiple interactions |
ISO |
shogaol analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased expression of CHUK protein] |
CTD |
PMID:23899529 |
|
NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
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G |
Ctnnb1 |
catenin beta 1 |
decreases expression |
ISO |
shogaol results in decreased expression of CTNNB1 mRNA; shogaol results in decreased expression of CTNNB1 protein |
CTD |
PMID:27645308 |
|
NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
multiple interactions increases expression |
ISO |
Acetylcysteine inhibits the reaction [shogaol results in increased expression of DDIT3 mRNA]; Acetylcysteine inhibits the reaction [shogaol results in increased expression of DDIT3 protein] shogaol results in increased expression of DDIT3 mRNA; shogaol results in increased expression of DDIT3 protein |
CTD |
PMID:18384088 |
|
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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G |
Dffa |
DNA fragmentation factor subunit alpha |
increases degradation |
ISO |
shogaol results in increased degradation of DFFA protein |
CTD |
PMID:18384088 |
|
NCBI chr 5:159,540,715...159,553,639
Ensembl chr 5:159,540,715...159,553,633
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G |
Fabp4 |
fatty acid binding protein 4 |
multiple interactions increases expression |
ISO |
2-chloro-5-nitrobenzanilide inhibits the reaction [shogaol results in increased expression of FABP4 mRNA] |
CTD |
PMID:18577375 |
|
NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578
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G |
Fas |
Fas cell surface death receptor |
increases expression |
ISO |
shogaol results in increased expression of FAS protein |
CTD |
PMID:18384088 |
|
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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G |
Faslg |
Fas ligand |
increases expression |
ISO |
shogaol results in increased expression of FASLG protein |
CTD |
PMID:18384088 |
|
NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
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G |
Flt1 |
Fms related receptor tyrosine kinase 1 |
decreases expression |
ISO |
shogaol results in decreased expression of FLT1 protein |
CTD |
PMID:36341865 |
|
NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626
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G |
Ftl1 |
ferritin light chain 1 |
increases expression |
ISO |
shogaol metabolite results in increased expression of FTL protein; shogaol results in increased expression of FTL mRNA; shogaol results in increased expression of FTL protein |
CTD |
PMID:25148906 |
|
NCBI chr 1:95,936,387...95,938,234
Ensembl chr 1:95,936,387...95,939,725 Ensembl chr10:95,936,387...95,939,725
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G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
increases expression multiple interactions |
ISO |
shogaol metabolite results in increased expression of GCLC protein; shogaol results in increased expression of GCLC protein NFE2L2 gene mutant form inhibits the reaction [shogaol results in increased expression of GCLC mRNA] |
CTD |
PMID:25148906 |
|
NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
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G |
Gclm |
glutamate cysteine ligase, modifier subunit |
increases expression |
ISO |
shogaol metabolite results in increased expression of GCLM protein; shogaol results in increased expression of GCLM protein |
CTD |
PMID:25148906 |
|
NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
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G |
Gdf15 |
growth differentiation factor 15 |
increases expression |
ISO |
shogaol results in increased expression of GDF15 mRNA |
CTD |
PMID:25148906 |
|
NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055
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G |
Gpx4 |
glutathione peroxidase 4 |
decreases expression multiple interactions |
ISO |
shogaol results in decreased expression of GPX4 mRNA; shogaol results in decreased expression of GPX4 protein ferrostatin-1 inhibits the reaction [shogaol results in decreased expression of GPX4 protein] |
CTD |
PMID:36341865 |
|
NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982
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G |
Gsk3b |
glycogen synthase kinase 3 beta |
multiple interactions |
ISO |
shogaol results in increased expression of and results in increased phosphorylation of GSK3B protein |
CTD |
PMID:27645308 |
|
NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
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G |
H2ax |
H2A.X variant histone |
multiple interactions |
ISO |
shogaol analog inhibits the reaction [Doxorubicin results in increased phosphorylation of H2AX protein] |
CTD |
PMID:23899529 |
|
NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
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G |
Hmox1 |
heme oxygenase 1 |
multiple interactions increases expression |
ISO |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [shogaol metabolite results in increased expression of HMOX1 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [shogaol results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [shogaol metabolite results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [shogaol results in increased expression of HMOX1 protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [shogaol metabolite results in increased expression of HMOX1 protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [shogaol results in increased expression of HMOX1 protein] shogaol analog results in increased expression of HMOX1 protein; shogaol metabolite results in increased expression of HMOX1 protein; shogaol results in increased expression of HMOX1 mRNA; shogaol results in increased expression of HMOX1 protein KEAP1 protein affects the reaction [shogaol analog results in increased expression of HMOX1 protein]; NFE2L2 gene mutant form inhibits the reaction [shogaol results in increased expression of HMOX1 protein] shogaol analog results in increased expression of HMOX1 protein; shogaol results in increased expression of HMOX1 protein |
CTD |
PMID:23899529 PMID:25148906 PMID:36341865 |
|
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Ikbkb |
inhibitor of nuclear factor kappa B kinase subunit beta |
multiple interactions |
ISO |
shogaol analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased expression of IKBKB protein] |
CTD |
PMID:23899529 |
|
NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
shogaol inhibits the reaction [IL1B protein results in increased expression of PTGES protein] |
CTD |
PMID:27645308 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Keap1 |
Kelch-like ECH-associated protein 1 |
multiple interactions decreases expression increases alkylation |
ISO |
KEAP1 protein affects the reaction [shogaol analog results in increased expression of HMOX1 protein]; KEAP1 protein affects the reaction [shogaol analog results in increased expression of NFE2L2 protein]; KEAP1 protein affects the reaction [shogaol analog results in increased expression of NQO1 protein] shogaol metabolite results in decreased expression of KEAP1 protein; shogaol results in decreased expression of KEAP1 protein shogaol results in increased alkylation of KEAP1 protein |
CTD |
PMID:23899529 PMID:25148906 |
|
NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions decreases phosphorylation |
ISO |
shogaol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein] shogaol results in decreased phosphorylation of MAPK1 protein |
CTD |
PMID:18683823 PMID:36341865 |
|
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions decreases phosphorylation |
ISO |
shogaol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein] shogaol results in decreased phosphorylation of MAPK3 protein |
CTD |
PMID:18683823 PMID:36341865 |
|
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mmp2 |
matrix metallopeptidase 2 |
affects expression decreases expression multiple interactions |
ISO |
shogaol affects the expression of MMP2 mRNA shogaol results in decreased expression of MMP2 protein AKT activator SC79 inhibits the reaction [shogaol results in decreased expression of MMP2 protein] |
CTD |
PMID:36341865 |
|
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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G |
Mmp9 |
matrix metallopeptidase 9 |
multiple interactions decreases expression |
ISO |
shogaol analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased secretion of MMP9 protein]; shogaol analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA] shogaol results in decreased expression of MMP9 mRNA; shogaol results in decreased expression of MMP9 protein |
CTD |
PMID:23899529 PMID:36341865 |
|
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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G |
Mt1 |
metallothionein 1 |
multiple interactions increases expression |
ISO |
NFE2L2 gene mutant form inhibits the reaction [shogaol results in increased expression of MT1 mRNA]; NFE2L2 gene mutant form inhibits the reaction [shogaol results in increased expression of MT1 protein] shogaol results in increased expression of MT1 mRNA; shogaol results in increased expression of MT1 protein |
CTD |
PMID:25148906 |
|
NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049 Ensembl chr17:10,826,032...10,827,049
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
increases expression multiple interactions affects localization |
ISO |
shogaol analog results in increased expression of NFE2L2 protein 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [shogaol affects the localization of and results in increased phosphorylation of NFE2L2 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [shogaol metabolite affects the localization of NFE2L2 protein modified form]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [shogaol metabolite affects the localization of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [shogaol affects the localization of and results in increased phosphorylation of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [shogaol metabolite affects the localization of NFE2L2 protein modified form]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [shogaol metabolite affects the localization of NFE2L2 protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [shogaol affects the localization of and results in increased phosphorylation of NFE2L2 protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [shogaol metabolite affects the localization of NFE2L2 protein modified form]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [shogaol metabolite affects the localization of NFE2L2 protein]; shogaol metabolite results in increased expression of and results in increased phosphorylation of NFE2L2 protein; shogaol results in increased expression of and results in increased phosphorylation of NFE2L2 protein shogaol affects the localization of NFE2L2 protein; shogaol metabolite affects the localization of NFE2L2 protein; shogaol metabolite affects the localization of NFE2L2 protein modified form KEAP1 protein affects the reaction [shogaol analog results in increased expression of NFE2L2 protein]; NFE2L2 gene mutant form inhibits the reaction [shogaol results in increased expression of GCLC mRNA]; NFE2L2 gene mutant form inhibits the reaction [shogaol results in increased expression of HMOX1 protein]; NFE2L2 gene mutant form inhibits the reaction [shogaol results in increased expression of MT1 mRNA]; NFE2L2 gene mutant form inhibits the reaction [shogaol results in increased expression of MT1 protein] |
CTD |
PMID:23899529 PMID:25148906 |
|
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
multiple interactions |
ISO |
shogaol inhibits the reaction [Lipopolysaccharides affects the localization of NFKB1 protein]; shogaol inhibits the reaction [Lipopolysaccharides results in increased activity of [NFKB1 protein binds to RELA protein]] |
CTD |
PMID:18683823 |
|
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO |
shogaol analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased expression of NFKBIA protein] shogaol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased degradation of NFKBIA protein] |
CTD |
PMID:18683823 PMID:23899529 |
|
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
shogaol analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of NOS2 protein] shogaol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; shogaol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; shogaol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of NOS2 protein] |
CTD |
PMID:18683823 PMID:23899529 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
multiple interactions increases expression |
ISO |
KEAP1 protein affects the reaction [shogaol analog results in increased expression of NQO1 protein] |
CTD |
PMID:23899529 |
|
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions increases cleavage |
ISO |
Acetylcysteine inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; Acetylcysteine inhibits the reaction [shogaol results in increased cleavage of PARP1 protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; CFLAR protein modified form inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; S-ethyl glutathione inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; shogaol promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein] |
CTD |
PMID:18384088 PMID:25619640 |
|
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
increases activity |
ISO |
shogaol results in increased activity of PPARG protein |
CTD |
PMID:18577375 |
|
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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G |
Ptges |
prostaglandin E synthase |
multiple interactions decreases expression |
ISO |
shogaol inhibits the reaction [IL1B protein results in increased expression of PTGES protein] shogaol results in decreased expression of PTGES mRNA |
CTD |
PMID:27645308 |
|
NCBI chr 3:14,177,892...14,189,236
|
|
G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
shogaol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; shogaol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; shogaol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein] shogaol analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein] |
CTD |
PMID:18683823 PMID:23899529 |
|
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
shogaol inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein]; shogaol inhibits the reaction [Lipopolysaccharides results in increased activity of [NFKB1 protein binds to RELA protein]]; shogaol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein] shogaol analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of RELA protein] |
CTD |
PMID:18683823 PMID:23899529 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Slc5a7 |
solute carrier family 5 member 7 |
multiple interactions increases expression |
ISO |
[shogaol co-treated with Hydrogen Peroxide] results in increased expression of SLC5A7 protein; shogaol inhibits the reaction [Hydrogen Peroxide results in decreased expression of SLC5A7 protein]; staurosporine aglycone inhibits the reaction [[shogaol co-treated with Hydrogen Peroxide] results in increased expression of SLC5A7 protein] [shogaol results in increased expression of BDNF protein] which results in increased expression of SLC5A7 protein; shogaol results in increased expression of SLC5A7 protein |
CTD |
PMID:22381256 |
|
NCBI chr 9:7,595,440...7,626,258
Ensembl chr 9:7,595,444...7,626,258
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G |
Slc7a11 |
solute carrier family 7 member 11 |
decreases expression |
ISO |
shogaol results in decreased expression of SLC7A11 mRNA; shogaol results in decreased expression of SLC7A11 protein |
CTD |
PMID:36341865 |
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NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
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G |
Sod2 |
superoxide dismutase 2 |
decreases expression |
ISO |
shogaol results in decreased expression of SOD2 mRNA; shogaol results in decreased expression of SOD2 protein |
CTD |
PMID:36341865 |
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NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
shogaol inhibits the reaction [TNF protein results in decreased expression of and results in decreased secretion of ADIPOQ protein] |
CTD |
PMID:18577375 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tnfsf10 |
TNF superfamily member 10 |
multiple interactions increases response to substance |
ISO |
[shogaol co-treated with TNFSF10 protein] results in increased cleavage of CASP3 protein; Acetylcysteine inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in decreased expression of CFLAR protein modified form]]; Acetylcysteine inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [[shogaol co-treated with TNFSF10 protein] results in increased cleavage of CASP3 protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; CFLAR protein modified form inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; S-ethyl glutathione inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in decreased expression of CFLAR protein modified form]]; S-ethyl glutathione inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; shogaol promotes the reaction [TNFSF10 protein results in decreased expression of CFLAR protein modified form]; shogaol promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein] shogaol results in increased susceptibility to TNFSF10 protein |
CTD |
PMID:25619640 |
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NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
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G |
Vim |
vimentin |
decreases expression multiple interactions |
ISO |
shogaol results in decreased expression of VIM mRNA; shogaol results in decreased expression of VIM protein ferrostatin-1 inhibits the reaction [shogaol results in decreased expression of VIM protein] |
CTD |
PMID:36341865 |
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NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
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