Il1b (interleukin 1 beta) - Rat Genome Database

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Gene: Il1b (interleukin 1 beta) Rattus norvegicus
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Symbol: Il1b
Name: interleukin 1 beta
RGD ID: 2891
Description: Enables cytokine activity. Involved in several processes, including positive regulation of intracellular signal transduction; regulation of gene expression; and response to monosaccharide. Located in extracellular space. Used to study several diseases, including artery disease (multiple); brain disease (multiple); glomerulonephritis (multiple); interstitial lung disease (multiple); and kidney failure (multiple). Biomarker of several diseases, including artery disease (multiple); brain disease (multiple); kidney failure (multiple); liver disease (multiple); and lung disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); blood platelet disease (multiple); cervix disease (multiple); eye disease (multiple); and lung disease (multiple). Orthologous to human IL1B (interleukin 1 beta); PARTICIPATES IN pro-inflammatory cytokine mediated pathway; interleukin-1 signaling pathway; interleukin-12 signaling pathway; INTERACTS WITH (+)-catechin; (+)-pilocarpine; (+)-taxifolin.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: IL-1 beta; IL-1F2; interleukin-1 beta
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83137,030,200 - 137,036,581 (-)NCBIGRCr8
mRatBN7.23116,577,005 - 116,583,386 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3116,577,010 - 116,583,415 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3120,474,110 - 120,480,521 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03129,069,733 - 129,076,144 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03126,730,207 - 126,736,618 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03121,876,256 - 121,882,637 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3121,876,263 - 121,882,726 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03128,133,929 - 128,140,354 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43116,964,422 - 116,970,867 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13116,869,999 - 116,876,460 (-)NCBI
Celera3115,403,045 - 115,409,735 (-)NCBICelera
RH 3.4 Map31000.1RGD
Cytogenetic Map3q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (IEP)
acute kidney failure  (IDA,IEP,ISO)
Acute Lung Injury  (IDA,IEP,ISO)
acute myocardial infarction  (IEP)
acute necrotizing pancreatitis  (IEP)
adenocarcinoma  (ISO)
adult respiratory distress syndrome  (ISO)
agranulocytosis  (ISO)
AIDS Dementia Complex  (IEP)
Albuminuria  (ISO)
Alcoholic Liver Diseases  (IEP)
allergic conjunctivitis  (ISO)
allergic disease  (ISO)
allergic rhinitis  (ISO)
Alport syndrome  (ISO)
Alveolar Bone Loss  (IEP)
Alzheimer's disease  (IDA,IEP,ISO)
anemia  (ISO)
Animal Disease Models  (ISO)
Anorexia  (IEP,ISO)
anthracosis  (ISO)
anthrax disease  (ISO)
anti-basement membrane glomerulonephritis  (IEP,ISO)
antisynthetase syndrome  (ISO)
Arsenic Poisoning  (ISO)
arteriosclerosis  (IEP,ISO)
asbestosis  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
atopic dermatitis  (ISO)
atrophic gastritis  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
bacterial pneumonia  (ISO)
Behcet's disease  (ISO)
Brain Contusion  (IEP)
Brain Hypoxia-Ischemia  (IEP)
brain infarction  (IEP)
Brain Injuries  (IEP,ISO)
brain ischemia  (ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
Bronchial Hyperreactivity  (ISO)
bronchiectasis  (ISO)
bronchiolitis  (ISO)
bronchopulmonary dysplasia  (ISO)
Burns  (ISO)
Cachexia  (IDA)
calcinosis  (ISO)
Cardiomegaly  (IEP,ISO)
cardiomyopathy  (ISO)
Cardiotoxicity  (ISO)
Cerebral Hemorrhage  (IEP)
cerebral infarction  (ISO)
cervical cancer  (ISO)
cervix uteri carcinoma in situ  (ISO)
Chemical and Drug Induced Liver Injury  (IDA,IEP,ISO)
Chemical Burns  (ISO)
Chemically-Induced Disorders  (ISO)
cholangiocarcinoma  (ISO)
cholesteatoma  (ISO)
Chronic Experimental Pancreatitis  (ISO)
Chronic Intermittent Hypoxia  (IEP)
chronic kidney disease  (IDA,ISO)
chronic myeloid leukemia  (ISO)
chronic obstructive pulmonary disease  (ISO)
chronic progressive external ophthalmoplegia  (ISO)
cochlear disease  (IEP)
Cognitive Dysfunction  (IDA,ISO)
colitis  (IDA,ISO)
Colonic Neoplasms  (ISO)
common cold  (ISO)
congestive heart failure  (ISO)
Contrast-Induced Nephropathy  (IDA)
coronary artery disease  (ISO)
Coronary Disease  (ISO)
COVID-19  (ISO)
crescentic glomerulonephritis  (IDA)
cutaneous leishmaniasis  (ISO)
cystic fibrosis  (ISO)
cystitis  (IDA,IEP)
dental caries  (ISO)
depressive disorder  (IEP,ISO)
dermatomyositis  (ISO)
Diabetic Nephropathies  (IDA,ISO)
diabetic neuropathy  (IEP)
diabetic retinopathy  (ISO)
disease of cellular proliferation  (ISO)
Disease Progression  (ISO)
Drug Hypersensitivity Syndrome  (ISO)
Drug-Induced Agranulocytosis  (ISO)
Drug-Induced Immune Thrombocytopenia  (ISO)
dry eye syndrome  (ISO)
Eales Disease  (ISO)
Edema  (ISO)
encephalitis  (IEP)
end stage renal disease  (IDA,IEP,ISO)
endometriosis  (ISO)
endophthalmitis  (IEP)
Endotoxemia  (IEP)
Entamoebiasis  (ISO)
Enterocolitis  (IEP)
epididymitis  (IEP)
epilepsy  (IEP)
esophageal cancer  (ISO)
essential hypertension  (ISO)
Experimental Arthritis  (IDA,IEP,ISO)
Experimental Autoimmune Neuritis  (IEP)
Experimental Colitis  (ISO)
Experimental Diabetes Mellitus  (IDA,IEP,ISO)
Experimental Liver Cirrhosis  (IEP,ISO)
Experimental Melanoma  (ISO)
Experimental Radiation Injuries  (ISO)
Experimental Seizures  (IEP)
extrahepatic cholestasis  (ISO)
extrinsic allergic alveolitis  (IMP,ISO)
Eye Burns  (ISO)
eye disease  (ISO)
familial Mediterranean fever  (ISO)
Febrile Seizures  (IDA)
Fever  (IEP,ISO)
Fibrosis  (ISO)
focal segmental glomerulosclerosis  (ISO)
Gallbladder Neoplasms  (ISO)
gastric adenocarcinoma  (ISO)
gastric dilatation  (ISO)
gastric ulcer  (ISO)
Genetic Predisposition to Disease  (ISO)
glioblastoma  (ISO)
glomerulonephritis  (ISO)
glomerulosclerosis  (IDA)
gout  (ISO)
Gram-Negative Bacterial Infections  (ISO)
Graves' disease  (ISO)
Heart Injuries  (IEP,ISO)
heart valve disease  (ISO)
Heat Stroke  (IEP,ISO)
Helicobacter Infections  (ISO)
hemolytic-uremic syndrome  (ISO)
Hemorrhagic Shock  (IEP)
hepatitis C  (ISO)
hepatocellular carcinoma  (ISO)
herpes simplex virus keratitis  (ISO)
HIV Wasting Syndrome  (ISO)
Human Influenza  (ISO)
hydronephrosis  (IEP)
Hyperalgesia  (IDA,ISO)
Hypercholesterolemia  (ISO)
Hyperemia  (ISO)
hyperglycemia  (IEP)
hyperhomocysteinemia  (ISO)
hypertension  (IDA,IEP,ISO)
hypoglycemia  (ISO)
hypolipoproteinemia  (ISO)
Hypotension  (ISO)
IgA glomerulonephritis  (ISO)
Inflammation  (IDA,IEP,ISO)
Insulin Resistance  (IEP,ISO)
Invasive Pulmonary Aspergillosis  (ISO)
Kawasaki disease  (ISO)
Kearns-Sayre syndrome  (ISO)
keratoconus  (ISO)
kidney failure  (IDA,ISO)
Kidney Reperfusion Injury  (IDA,ISO)
learning disability  (ISO)
Leber hereditary optic neuropathy  (ISO)
leptospirosis  (ISO)
Lethargy  (ISO)
Leukocytosis  (ISO)
liver cirrhosis  (IEP)
Liver Reperfusion Injury  (IDA,ISO)
lung disease  (IEP,ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
Lung Reperfusion Injury  (IDA,IEP,ISO)
lupus nephritis  (ISO)
Lyme Neuroborreliosis  (IDA)
lymphopenia  (ISO)
Manganese Poisoning  (ISO)
MELAS syndrome  (ISO)
membranoproliferative glomerulonephritis  (IDA)
membranous glomerulonephritis  (IDA)
Memory Disorders  (ISO)
MERRF Syndrome  (ISO)
metabolic dysfunction-associated steatohepatitis  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
middle cerebral artery infarction  (IEP,ISO)
Middle East respiratory syndrome  (ISO)
mitochondrial myopathy  (ISO)
mucositis  (IDA,ISO)
multiple myeloma  (ISO)
Multiple Organ Failure  (IDA,ISO)
multiple sclerosis  (ISO)
muscular disease  (ISO)
myelodysplastic syndrome  (ISO)
myocardial infarction  (IDA,IEP,ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (IEP)
Necrosis  (ISO)
Neoplasm Invasiveness  (ISO)
nephrosis  (IDA)
nephrotic syndrome  (IEP,ISO)
neuroblastoma  (ISO)
neutropenia  (ISO)
Neutropenic Enterocolitis  (IEP)
obesity  (IEP,ISO)
obstructive sleep apnea  (IEP,ISO)
oral squamous cell carcinoma  (IEP)
osteoarthritis  (IEP,ISO)
osteoporosis  (IDA)
otitis media  (IEP)
Otitis Media with Effusion  (ISO)
Oxygen-Induced Retinopathy  (ISO)
pancreatic cancer  (ISO)
Pancreatic Cyst  (ISO)
pancreatitis  (IDA)
PAPA syndrome  (ISO)
paracoccidioidomycosis  (ISO)
Parkinson's disease  (IDA,ISO)
Parkinsonism  (IMP)
peptic ulcer disease  (ISO)
perinatal necrotizing enterocolitis  (IDA)
periodontitis  (IEP,ISO)
Peripheral Nerve Injuries  (IDA)
plague  (ISO)
pleural tuberculosis  (ISO)
pleurisy  (IDA,IEP,ISO)
pneumonia  (IEP,ISO)
polymyositis  (ISO)
polyneuropathy  (IEP)
portal hypertension  (IEP)
Postmenopausal Osteoporosis  (ISO)
Postoperative Cognitive Dysfunction  (IDA,IEP)
Presenile and Senile Dementia  (IDA)
primary biliary cholangitis  (ISO)
Pseudomonas Aeruginosa Keratitis  (ISO)
Pseudomonas Infections  (ISO)
psoriasis  (ISO)
pulmonary edema  (ISO)
pulmonary fibrosis  (IDA,IEP,ISO)
pulmonary hypertension  (ISO)
pulmonary tuberculosis  (ISO)
Reperfusion Injury  (ISO)
respiratory allergy  (ISO)
Retina Reperfusion Injury  (IEP)
retinal vein occlusion  (IEP)
retinitis  (ISO)
retinopathy of prematurity  (IDA)
rheumatoid arthritis  (ISO)
rhinitis  (IEP,ISO)
Rhinosinusitis  (ISO)
schizophrenia  (ISO)
sciatic neuropathy  (IEP)
Sepsis  (IEP,ISO)
severe acute respiratory syndrome  (ISO)
shigellosis  (ISO)
silicosis  (ISO)
sinusitis  (ISO)
skin disease  (ISO)
sleep disorder  (ISO)
Small-For-Size Syndrome  (IDA)
Spinal Cord Injuries  (IDA,IEP)
Spontaneous Abortions  (ISO)
Staphylococcal Pneumonia  (ISO)
status asthmaticus  (ISO)
status epilepticus  (IDA,IEP)
steatotic liver disease  (IEP,ISO)
stomach cancer  (ISO)
Stomach Neoplasms  (ISO)
Stroke  (ISO)
Subarachnoid Hemorrhage  (ISO)
Systemic Inflammatory Response Syndrome  (ISO)
systemic lupus erythematosus  (ISO)
systemic scleroderma  (ISO)
thalassemia  (ISO)
thrombocytopenia  (ISO)
thrombocytosis  (ISO)
Thyroid Neoplasms  (ISO)
toxic shock syndrome  (ISO)
transient cerebral ischemia  (IDA,ISO)
Transplant Rejection  (ISO)
traumatic brain injury  (ISO)
trigeminal neuralgia  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
ulcerative colitis  (IEP,ISO)
ureteral obstruction  (IDA,ISO)
urinary bladder cancer  (ISO)
urinary tract infection  (IEP,ISO)
urticaria  (ISO)
uveitis  (IEP,ISO)
varicocele  (IEP)
vascular dementia  (ISO)
Venous Thrombosis  (IEP)
Ventilator-Induced Lung Injury  (IDA,IMP,ISO)
viral pneumonia  (ISO)
visceral leishmaniasis  (ISO)
Vulvar Vestibulitis  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-albicanol  (ISO)
(+)-catechin  (EXP,ISO)
(+)-epicatechin-3-O-gallate  (ISO)
(+)-isoborneol  (ISO)
(+)-pilocarpine  (EXP,ISO)
(+)-sesamin  (ISO)
(+)-syringaresinol beta-D-glucoside  (ISO)
(+)-taxifolin  (EXP,ISO)
(+)-Tetrandrine  (EXP,ISO)
(-)-anisomycin  (ISO)
(-)-Arctigenin  (ISO)
(-)-citrinin  (ISO)
(-)-cotinine  (EXP)
(-)-ephedrine  (EXP)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(-)-quinic acid  (ISO)
(20S)-ginsenoside Rg3  (EXP,ISO)
(20S)-ginsenoside Rh1  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(2E,4E)-hexa-2,4-dienoic acid  (EXP)
(4Z,7Z,10Z,13Z,15E,19Z)-17-hydroxydocosahexaenoic acid  (ISO)
(5Z,8Z,11Z,13E)-15-HETE  (ISO)
(E)-cinnamyl alcohol  (ISO)
(E)-roxithromycin  (EXP,ISO)
(E)-thiamethoxam  (EXP)
(R)-adrenaline  (ISO)
(R)-carnitine  (EXP)
(R)-lipoic acid  (EXP,ISO)
(R)-noradrenaline  (EXP)
(R,R,R)-alpha-tocopherol  (EXP,ISO)
(S)-colchicine  (EXP,ISO)
(S)-magnoflorine  (EXP)
(S)-naringenin  (EXP,ISO)
(S)-nicotine  (EXP,ISO)
(S)-ropivacaine  (ISO)
(Z)-ligustilide  (ISO)
1'-acetoxychavicol acetate  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,1-bis(2-aminoethyl)-2-hydroxy-3-oxotriazane  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1,3,7,9-tetramethyluric acid  (EXP)
1,3-benzothiazole-2-thiol  (ISO)
1,3-dichloropropan-2-ol  (ISO)
1,4-dithiothreitol  (ISO)
1,4-phenylenediamine  (ISO)
1,8-cineole  (EXP)
1-[(2,3,4-trimethoxyphenyl)methyl]piperazine  (EXP,ISO)
1-[2-(3,4-dichlorophenyl)ethyl]-4-methylpiperazine  (ISO)
1-bromopropane  (ISO)
1-chloro-2,4,6-trinitrobenzene  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-hydroxy-2-naphthoic acid  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP,ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
1-nitropyrene  (ISO)
1-O-palmitoyl-2-O-(5-oxovaleryl)-sn-glycero-3-phosphocholine  (ISO)
1-octadec-9-enoylglycero-3-phosphate  (ISO)
1-phenyl-1-cyclopentanecarboxylic acid 2-[2-(diethylamino)ethoxy]ethyl ester  (ISO)
11-deoxycorticosterone  (EXP)
15-acetyldeoxynivalenol  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP,ISO)
15-oxo-ETE  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
1H-imidazole  (ISO)
1H-pyrazole  (ISO)
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2'-bipyridine  (ISO)
2,2,2-trichloroethanol  (ISO)
2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9-hexadecafluorononanoic acid  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,3-bis(4-hydroxyphenyl)propionitrile  (EXP)
2,4,6-trinitrobenzenesulfonic acid  (EXP,ISO)
2,4-D  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,5-hexanedione  (EXP)
2,6-dinitrotoluene  (EXP)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (EXP)
2-acetamidofluorene  (EXP,ISO)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (ISO)
2-amino-2-deoxy-D-galactopyranose  (EXP,ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
2-arachidonoylglycerol  (ISO)
2-bromo-2-(bromomethyl)pentanedinitrile  (ISO)
2-chloroethanol  (ISO)
2-deoxy-D-glucose  (ISO)
2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid  (ISO)
2-hydroxyethyl methacrylate  (ISO)
2-methoxy-17beta-estradiol  (EXP)
2-methyl-1,4-phenylenediamine  (ISO)
2-methylserotonin  (ISO)
2-nitrofluorene  (ISO)
2-palmitoylglycerol  (ISO)
2-tert-butylhydroquinone  (EXP,ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
2-trans,6-trans-farnesyl diphosphate  (ISO)
25-hydroxycholesterol  (ISO)
26-hydroxycholesterol  (ISO)
3',5'-cyclic AMP  (ISO)
3',5'-cyclic GMP  (EXP,ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3'-O-(4-Benzoyl)benzoyl ATP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-1-decanol  (ISO)
3,4-dihydroxybenzoic acid  (EXP,ISO)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
3-acetyldeoxynivalenol  (ISO)
3-aminobenzamide  (ISO)
3-chloropropane-1,2-diol  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-mercaptopropanoic acid  (ISO)
3-methyladenine  (EXP,ISO)
3-methylcholanthrene  (ISO)
3-Nitrobenzanthrone  (ISO)
3-nitropropanoic acid  (EXP)
3-nitrotyrosine  (ISO)
3-phenylprop-2-enal  (EXP,ISO)
3alpha-hydroxy-5beta-pregnan-20-one  (ISO)
3beta-(2-diethylaminoethoxy)androst-5-en-17-one hydrochloride  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4',5,7-Trimethoxyflavone  (ISO)
4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-[6-(diaminomethylideneamino)-1-oxohexoxy]benzoic acid ethyl ester  (EXP)
4-\{[4-(dimethylamino)phenyl]diazenyl\}phenyl-beta-lactoside  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxy-TEMPO  (EXP,ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-2-thiophenecarboxylic acid methyl ester  (ISO)
4-nitroaniline  (ISO)
4-nitrobenzyl bromide  (ISO)
4-nitroquinoline N-oxide  (EXP,ISO)
4-nonylphenol  (EXP,ISO)
4-phenylbutyric acid  (EXP,ISO)
5'-S-methyl-5'-thioadenosine  (ISO)
5,6,7-trimethoxyflavone  (ISO)
5-aminoimidazole-4-carboxamide  (EXP)
5-aza-2'-deoxycytidine  (EXP,ISO)
5-azacytidine  (EXP,ISO)
5-fluorouracil  (EXP,ISO)
5-formyltetrahydrofolic acid  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
5-methoxypsoralen  (EXP)
6-aminonicotinamide  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP,ISO)
6-Methoxyflavone  (ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (EXP)
7,12-dimethyltetraphene  (EXP,ISO)
7,8-dihydroxycoumarin  (EXP,ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (EXP,ISO)
7-ketocholesterol  (ISO)
8-Br-cAMP  (ISO)
8-bromo-3',5'-cyclic GMP  (ISO)
8-chloro-2'-deoxyguanosine  (ISO)
8-epi-prostaglandin F2alpha  (EXP,ISO)
8-OH-DPAT  (ISO)
9-cis-retinoic acid  (ISO)
[6]-Shogaol  (ISO)
AACOCF3  (ISO)
abamectin  (EXP)
acetaldehyde  (ISO)
acetate ester  (ISO)
acetic acid  (EXP,ISO)
acetic anhydride  (ISO)
acetyl-CoA  (ISO)
acetylcholine  (ISO)
acetylleucyl-leucyl-norleucinal  (ISO)
acetylsalicylic acid  (EXP,ISO)
aconitine  (EXP,ISO)
acrolein  (EXP,ISO)
acrylamide  (EXP,ISO)
acrylonitrile  (EXP)
actinomycin D  (EXP,ISO)
acyclovir  (ISO)
adenine  (ISO)
adenosine  (EXP)
adenosine 5'-[gamma-thio]triphosphate  (ISO)
aflatoxin B1  (ISO)
Aflatoxin G1  (ISO)
agathisflavone  (EXP)
agmatine  (EXP)
AICA ribonucleotide  (ISO)
ajmalicine  (ISO)
albuterol  (ISO)
aldehydo-D-glucosamine  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
alendronic acid  (EXP,ISO)
aliskiren  (EXP)
Alisol B  (ISO)
Alkannin  (ISO)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (EXP)
allantoin  (EXP,ISO)
allethrin  (ISO)
allicin  (EXP,ISO)
allopurinol  (EXP,ISO)
alloxan  (ISO)
allyl alcohol  (EXP)
allyl methyl disulfide  (ISO)
Alpha-Boswellic acid  (ISO)
alpha-Chaconine  (ISO)
alpha-D-galactose  (EXP,ISO)
alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide  (ISO)
alpha-linolenic acid  (EXP,ISO)
alpha-methylhistamine  (ISO)
alpha-naphthoflavone  (ISO)
alpha-pinene  (EXP)
alpha-Solamarine  (ISO)
Alternaramide  (ISO)
alternariol  (ISO)
Altertoxin II  (ISO)
aluminium atom  (EXP)
aluminium hydroxide  (ISO)
aluminium oxide  (ISO)
aluminium sulfate (anhydrous)  (ISO)
aluminium(0)  (EXP)
AM-251  (ISO)
amentoflavone  (ISO)
amikacin  (ISO)
amiloride  (ISO)
aminoguanidine  (EXP,ISO)
aminophenazone  (ISO)
amiodarone  (EXP,ISO)
amitriptyline  (ISO)
amitrole  (EXP)
amlexanox  (ISO)
ammonia  (EXP,ISO)
ammonium acetate  (EXP)
ammonium chloride  (EXP,ISO)
ammonium nitrate  (ISO)
Ammothamnine  (EXP,ISO)
amosite asbestos  (EXP,ISO)
amphetamine  (EXP)
amphibole asbestos  (EXP,ISO)
amphotericin B  (ISO)
ampicillin  (EXP,ISO)
amrinone  (ISO)
anandamide  (ISO)
andrographolide  (ISO)
Anemoside B4  (ISO)
anethole  (EXP)
angiotensin II  (ISO)
anthocyanin  (EXP,ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
anthracen-2-amine  (EXP,ISO)
antigen  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
Apafant  (EXP,ISO)
apigenin  (EXP,ISO)
apocynin  (EXP,ISO)
arachidonic acid  (ISO)
aripiprazole  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (EXP)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
artesunate  (EXP)
asarone  (ISO)
asiatic acid  (ISO)
aspartame  (ISO)
asperentin  (ISO)
astaxanthin  (EXP,ISO)
astemizole  (ISO)
astilbin  (ISO)
astragaloside IV  (EXP)
atorvastatin calcium  (EXP,ISO)
ATP  (EXP,ISO)
atrazine  (EXP,ISO)
atropine  (ISO)
aucubin  (ISO)
auranofin  (ISO)
aurantio-obtusin  (ISO)
Aurin  (ISO)
Aurothioglucose  (ISO)
azathioprine  (ISO)
azithromycin  (ISO)
bafilomycin A1  (ISO)
baicalein  (ISO)
baicalin  (ISO)
BAPTA  (ISO)
Bardoxolone methyl  (ISO)
barium chloride  (EXP)
Bavachinin  (ISO)
BAY 60-6583  (ISO)
beclomethasone  (ISO)
bellidifolin  (ISO)
Belnacasan  (EXP,ISO)
benfotiamine  (ISO)
benzalkonium chloride  (ISO)
benzamide  (EXP)
benzatropine  (ISO)
benzbromarone  (ISO)
benzene  (EXP,ISO)
benzethonium chloride  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
benzyl bromide  (ISO)
benzylpenicillin  (ISO)
berberine  (EXP,ISO)
Bergenin  (EXP,ISO)
beryllium atom  (ISO)
beryllium dihydride  (ISO)
beryllium(0)  (ISO)
Besigomsin  (ISO)
beta-amyrin  (ISO)
beta-carotene  (ISO)
beta-cyclodextrin  (ISO)
beta-D-glucosamine  (EXP,ISO)
beta-D-glucosamine 6-sulfate  (ISO)
beta-eudesmol  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (ISO)
betalain  (ISO)
betulin  (ISO)
bezafibrate  (EXP,ISO)
bifenthrin  (EXP,ISO)
bilirubin IXalpha  (EXP,ISO)
biochanin A  (ISO)
biotin  (EXP)
biperiden  (ISO)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
Bisibuthiamine  (EXP)
bisoprolol  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP,ISO)
boldenone  (EXP)
Boldine  (EXP)
boric acid  (EXP)
boron atom  (EXP)
boron nitride  (ISO)
bortezomib  (EXP)
BQ 123  (ISO)
bromfenac  (ISO)
bromoacetate  (ISO)
bromodichloromethane  (ISO)
Bromoenol lactone  (ISO)
Brusatol  (ISO)
bucladesine  (ISO)
budesonide  (EXP,ISO)
Budlein A  (EXP)
bufalin  (ISO)
buspirone  (EXP)
buta-1,3-diene  (ISO)
butan-1-ol  (ISO)
butane-2,3-dione  (ISO)
butylated hydroxyanisole  (EXP,ISO)
Butylbenzyl phthalate  (ISO)
butyric acid  (ISO)
C.I. Natural Red 20  (ISO)
C60 fullerene  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium selenide  (ISO)
caffeine  (EXP,ISO)
Calcimycin  (ISO)
calcitriol  (EXP,ISO)
calcium atom  (ISO)
calcium dichloride  (EXP,ISO)
Calcium propionate  (EXP)
calcium(0)  (ISO)
calmidazolium  (ISO)
calycosin  (EXP)
camptothecin  (ISO)
candesartan  (EXP)
cannabidiol  (EXP,ISO)
cannabigerol  (EXP)
capsaicin  (EXP,ISO)
capsazepine  (ISO)
captan  (ISO)
carazolol  (ISO)
carbachol  (EXP)
carbamate ester  (ISO)
carbamazepine  (EXP)
carbendazim  (EXP,ISO)
carbidopa  (ISO)
carbon atom  (ISO)
carbon monoxide  (EXP,ISO)
carbon nanotube  (EXP,ISO)
Cardamonin  (ISO)
carmustine  (EXP)
carnosine  (ISO)
carrageenan  (EXP,ISO)
carvacrol  (EXP,ISO)
carvedilol  (EXP,ISO)
carveol  (ISO)
Cassiastearoptene  (EXP)
catalpol  (ISO)
CCCP  (ISO)
cefaloridine  (EXP)
cefoxitin  (ISO)
ceftaroline  (ISO)
ceftriaxone  (EXP)
celastrol  (EXP,ISO)
celecoxib  (EXP,ISO)
ceric oxide  (EXP)
cerium trichloride  (ISO)
cerivastatin  (EXP)
ceruletide  (EXP,ISO)
cetylpyridinium  (ISO)
CGP 52608  (ISO)
chaetoglobosin A  (ISO)
Chebulagic acid  (EXP)
chelerythrine  (ISO)
chenodeoxycholic acid  (ISO)
Chikusetsusaponin-IV  (ISO)
chitosan  (EXP)
chloral hydrate  (EXP)
chloramine T  (ISO)
chloroethene  (ISO)
chlorogenic acid  (EXP,ISO)
chloropicrin  (ISO)
chloroprene  (ISO)
chloroquine  (ISO)
chlorothalonil  (ISO)
chlorpromazine  (ISO)
chlorpyrifos  (EXP,ISO)
chlorquinaldol  (ISO)
cholesterol  (EXP,ISO)
cholic acid  (ISO)
choline  (ISO)
chondroitin sulfate  (ISO)
chromium atom  (ISO)
chromium(6+)  (EXP,ISO)
chrysene  (ISO)
chrysin  (EXP,ISO)
chrysin 5,7-dimethyl ether  (ISO)
ciglitazone  (ISO)
ciguatoxin CTX1B  (ISO)
cilostazol  (EXP,ISO)
cimetidine  (ISO)
cinnamyl alcohol  (ISO)
ciprofibrate  (ISO)
ciprofloxacin  (EXP,ISO)
cirsilineol  (ISO)
cis-caffeic acid  (EXP,ISO)
cisplatin  (EXP,ISO)
clavulanic acid  (ISO)
clenbuterol  (EXP)
clodronic acid  (ISO)
clofibrate  (ISO)
clonidine  (EXP,ISO)
clonidine (amino form)  (EXP,ISO)
clonidine (imino form)  (EXP,ISO)
clopidogrel  (ISO)
clorgyline  (ISO)
cloxacillin  (ISO)
clozapine  (EXP)
cobalt atom  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
cobalt(2+) sulfate  (ISO)
cocaine  (ISO)
coenzyme Q10  (EXP)
colforsin daropate hydrochloride  (EXP,ISO)
conjugated linoleic acid  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (EXP,ISO)
corilagin  (ISO)
corn oil  (EXP)
corticosterone  (EXP,ISO)
cortisol  (EXP,ISO)
cortisone  (ISO)
corynoline  (ISO)
coumarin  (EXP,ISO)
coumarins  (ISO)
coumermycin A1  (ISO)
crocidolite asbestos  (EXP,ISO)
crocin-1  (EXP)
crotonaldehyde  (EXP,ISO)
cucurbitacin B  (ISO)
cumene hydroperoxide  (ISO)
Cuprizon  (EXP,ISO)
curcumin  (EXP,ISO)
cyanocob(III)alamin  (ISO)
cyclizine  (ISO)
cycloastragenol  (EXP)
cycloheximide  (EXP,ISO)
Cyclopamine  (ISO)
cyclopentanol  (ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP,ISO)
cyprodinil  (ISO)
cytidine  (ISO)
cytochalasin B  (ISO)
cytochalasin D  (ISO)
D-glucose  (EXP,ISO)
D-penicillamine  (EXP)
daidzein  (ISO)
dantrolene  (EXP,ISO)
dapagliflozin  (EXP)
dapsone  (ISO)
DAPT  (EXP,ISO)
DDE  (EXP,ISO)
DDT  (ISO)
decabromodiphenyl ether  (EXP,ISO)
Decursin  (ISO)
dehydroepiandrosterone  (EXP)
dehydroepiandrosterone sulfate  (ISO)
delta-tocotrienol  (ISO)
delta8-THC  (ISO)
deoxycholic acid  (ISO)
Deoxycorticosterone acetate  (ISO)
deoxynivalenol  (EXP,ISO)
Deoxynivalenol 3-glucoside  (ISO)
desferrioxamine B  (ISO)
desipramine  (EXP)
dexamethasone  (EXP,ISO)
dexamethasone phosphate  (ISO)
dexmedetomidine  (ISO)
dextran sulfate  (EXP,ISO)
Di-n-hexyl phthalate  (ISO)
diallyl disulfide  (ISO)
Diallyl sulfide  (EXP,ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (ISO)
diazoxon  (ISO)
dibenziodolium  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dibutylstannane  (ISO)
dichlorine  (EXP,ISO)
dichlorvos  (EXP)
dichromium trioxide  (ISO)
diclofenac  (EXP,ISO)
dicloxacillin  (ISO)
dicoumarol  (ISO)
Dictamnine  (ISO)
Didecyldimethylammonium  (ISO)
dieckol  (ISO)
dieldrin  (EXP)
diethyl dithiophosphate  (ISO)
diethyl maleate  (ISO)
diethyl phthalate  (EXP,ISO)
diethyldithiocarbamic acid  (ISO)
diflunisal  (EXP)
digitoxin  (ISO)
dihydroartemisinin  (ISO)
Dihydrotanshinone I  (ISO)
diiodine  (EXP)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
diisopropyl fluorophosphate  (EXP,ISO)
dimemorfan  (EXP)
dimethoate  (ISO)
dimethyl fumarate  (ISO)
dimethyl sulfoxide  (EXP,ISO)
dimethyl-(phenylmethyl)-[2-[2-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]ethoxy]ethyl]ammonium  (ISO)
dimethylarsinic acid  (EXP)
diminazene diaceturate  (EXP,ISO)
dioscin  (EXP)
diosgenin  (EXP)
diosmetin  (EXP)
dioxygen  (EXP,ISO)
diphenhydramine  (ISO)
diprotium oxide  (EXP,ISO)
dipyridamole  (ISO)
diquat  (EXP,ISO)
disodium selenite  (EXP,ISO)
disulfiram  (ISO)
dithianon  (ISO)
dizocilpine maleate  (EXP)
dobutamine  (EXP,ISO)
donepezil hydrochloride  (EXP,ISO)
dopaminechrome (enol form)  (EXP)
doramapimod  (ISO)
dorsomorphin  (EXP,ISO)
doxepin  (EXP)
doxorubicin  (EXP,ISO)
doxycycline  (ISO)
EC 3.1.1.4 (phospholipase A2) inhibitor  (ISO)
edaravone  (EXP,ISO)
efavirenz  (EXP)
elemental boron  (EXP)
elemental carbon  (ISO)
elemental selenium  (EXP,ISO)
ellagic acid  (EXP,ISO)
emamectin benzoate  (ISO)
embelin  (EXP)
emodin  (EXP,ISO)
empagliflozin  (EXP)
enalapril  (EXP,ISO)
endosulfan  (EXP,ISO)
enflurane  (EXP)
enilconazole  (ISO)
enniatin  (ISO)
entacapone  (ISO)
Enterolactone  (ISO)
enzyme inhibitor  (EXP)
epalrestat  (ISO)
eplerenone  (EXP)
epoxiconazole  (ISO)
erdosteine  (ISO)
ergosterol  (EXP)
eriodictyol  (ISO)
Erionite  (ISO)
erlotinib hydrochloride  (ISO)
erythromycin A  (ISO)
esmolol  (ISO)
etacrynic acid  (ISO)
ethambutol  (EXP)
ethanol  (EXP,ISO)
ethion  (ISO)
ethionamide  (EXP)
Ethyl icosapentate  (EXP,ISO)
Ethylenethiourea  (ISO)
ethylisopropylamiloride  (ISO)
ethylmalonic acid  (EXP)
etodolac  (ISO)
etoposide  (ISO)
eugenol  (ISO)
eupatilin  (EXP,ISO)
Evodiamine  (ISO)
excitatory amino acid agonist  (EXP)
ezogabine  (EXP)
famotidine  (EXP,ISO)
Fargesin  (ISO)
farnesol  (ISO)
farnesyl diphosphate  (ISO)
farrerol  (EXP)
fasudil  (EXP,ISO)
fenitrothion  (EXP)
fenofibrate  (EXP,ISO)
fenpropathrin  (EXP)
fentin chloride  (ISO)
ferric ammonium citrate  (ISO)
ferric oxide  (ISO)
ferroheme b  (ISO)
ferrosoferric oxide  (EXP,ISO)
ferrostatin-1  (EXP,ISO)
Fexofenadine hydrochloride  (ISO)
Fidarestat  (ISO)
finasteride  (ISO)
fingolimod hydrochloride  (ISO)
fisetin  (EXP,ISO)
Flavokawain A  (ISO)
flavokawain B  (ISO)
flavone  (ISO)
flavonoids  (EXP)
flucloxacillin  (ISO)
fludrocortisone  (ISO)
flumequine  (ISO)
fluoxetine  (EXP,ISO)
flurbiprofen  (ISO)
flutamide  (EXP,ISO)
fluticasone  (ISO)
fluvastatin  (EXP)
folic acid  (ISO)
formaldehyde  (EXP,ISO)
formoterol fumarate  (ISO)
fragrance  (ISO)
Fraxinellone  (ISO)
fructose  (EXP,ISO)
fucoidan  (ISO)
fucoxanthin  (ISO)
fulvestrant  (EXP,ISO)
fumigaclavine C  (ISO)
fumonisin B1  (ISO)
furan  (EXP,ISO)
Fusarenone X  (ISO)
Fusaric acid  (ISO)
gadolinium atom  (ISO)
gadolinium trichloride  (EXP,ISO)
galactose  (EXP,ISO)
galangin  (EXP,ISO)
gallic acid  (EXP,ISO)
gallocatechin  (ISO)
Ganoderic acid A  (ISO)
Garcinol  (ISO)
Gastrodin  (EXP)
gefitinib  (ISO)
geldanamycin  (EXP,ISO)
Gelsemine  (ISO)
gemcitabine  (ISO)
gemfibrozil  (EXP,ISO)
Genipin  (ISO)
Geniposide  (EXP)
genistein  (EXP,ISO)
genkwanin  (ISO)
gentamycin  (EXP,ISO)
Geraniin  (ISO)
geraniol  (EXP,ISO)
geranylgeraniol  (ISO)
ghrelin  (ISO)
Gingerenone A  (ISO)
gingerol  (ISO)
Ginkgolide C  (EXP)
ginsenoside C-K  (ISO)
ginsenoside Rb1  (EXP,ISO)
ginsenoside Re  (ISO)
ginsenoside Rg1  (EXP,ISO)
glafenine  (EXP)
gliclazide  (EXP)
glucose  (EXP,ISO)
glutathione  (ISO)
glyburide  (EXP,ISO)
glycerol  (EXP,ISO)
glycidol  (EXP)
glycolic acid  (ISO)
glycyrol  (ISO)
glycyrrhetinate  (EXP,ISO)
glycyrrhetinic acid  (EXP,ISO)
glycyrrhizinic acid  (EXP)
glyoxal  (ISO)
glyphosate  (EXP,ISO)
Goe 6976  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
gossypin  (EXP)
GR 113808  (ISO)
granisetron  (ISO)
graphene oxide  (ISO)
graphite  (EXP,ISO)
guggulsterone  (ISO)
GW 4064  (ISO)
GW 501516  (ISO)
GW 6471  (EXP)
gypenoside LXXV  (ISO)
haloperidol  (ISO)
halothane  (EXP,ISO)
harmaline  (ISO)
Harpagide  (ISO)
heme b  (ISO)
hemin  (ISO)
herbacetin  (EXP)
herbimycin  (EXP)
hesperetin  (EXP,ISO)
hesperidin  (EXP,ISO)
Hexachloro-1,3-butadiene  (EXP)
hexachlorobenzene  (EXP)
hexadecanoic acid  (EXP,ISO)
hexane  (ISO)
hinokiflavone  (ISO)
hispidulin  (ISO)
histamine  (EXP)
homoeriodictyol  (ISO)
Honokiol  (ISO)
HU-308  (EXP,ISO)
huperzine A  (EXP)
hyaluronic acid  (EXP,ISO)
hydrocortisone succinate  (ISO)
hydrogen chloride  (EXP,ISO)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (EXP)
hydroquinone  (EXP,ISO)
hydroxychloroquine  (ISO)
hydroxylamine  (EXP)
hydroxysafflor yellow A  (ISO)
hydroxyzine  (ISO)
hypochlorous acid  (ISO)
hypoxanthine  (EXP,ISO)
Ibotenic acid  (EXP)
ibuprofen  (EXP,ISO)
icariin  (EXP,ISO)
icosanoid  (EXP)
ifosfamide  (EXP)
Iguratimod  (EXP)
Ile(5)-angiotensin II  (ISO)
iloprost  (ISO)
imidacloprid  (EXP,ISO)
Imipenem-cilastatin  (EXP,ISO)
imipramine  (ISO)
imiquimod  (ISO)
immunological adjuvant  (ISO)
IMP  (EXP)
indirubin-3'-monoxime  (ISO)
indole-3-methanol  (ISO)
indoline  (EXP)
indometacin  (EXP,ISO)
indoprofen  (ISO)
iohexol  (EXP,ISO)
ionomycin  (ISO)
irinotecan  (EXP,ISO)
iron atom  (EXP,ISO)
iron dextran  (EXP)
iron trichloride  (EXP,ISO)
iron(0)  (EXP,ISO)
iron(2+) sulfate (anhydrous)  (EXP,ISO)
isobutanol  (ISO)
isocyanates  (ISO)
isoflurane  (EXP,ISO)
isoniazide  (EXP,ISO)
isophorone diisocyanate  (ISO)
isoprenaline  (EXP,ISO)
isorhamnetin  (EXP,ISO)
isothiocyanate  (ISO)
isotretinoin  (EXP,ISO)
isovitexin  (EXP,ISO)
ivermectin  (ISO)
jaspamide  (EXP,ISO)
kaempferol  (ISO)
kaempferol 3-O-beta-D-glucoside  (ISO)
kahweol  (ISO)
kainic acid  (EXP,ISO)
ketamine  (EXP,ISO)
ketoconazole  (EXP,ISO)
ketorolac  (EXP)
ketotifen  (EXP,ISO)
KN-93  (ISO)
kojic acid  (EXP)
KT 5720  (ISO)
KT 5823  (ISO)
Kukoamine B  (ISO)
kuwanone G  (ISO)
kynurenic acid  (ISO)
L-1,4-dithiothreitol  (ISO)
L-arginine  (EXP,ISO)
L-ascorbic acid  (EXP,ISO)
L-dehydroascorbic acid  (EXP,ISO)
L-ethionine  (ISO)
L-gamma-glutamyl-L-cysteine  (ISO)
L-methionine  (ISO)
L-proline betaine  (ISO)
lactacystin  (ISO)
lactucin  (ISO)
lactulose  (EXP)
lamivudine  (EXP)
lansoprazole  (EXP,ISO)
Lasiocarpine  (ISO)
latrunculin A  (ISO)
latrunculin B  (EXP,ISO)
lead diacetate  (EXP,ISO)
lead nitrate  (EXP,ISO)
lead(0)  (EXP,ISO)
lead(II) chloride  (ISO)
leflunomide  (ISO)
lenalidomide  (EXP,ISO)
Leonurine  (EXP,ISO)
leptomycin B  (ISO)
leukotriene B4  (ISO)
levamisole  (ISO)
levetiracetam  (EXP)
levocabastine  (ISO)
levofloxacin  (ISO)
Licochalcone A  (ISO)
Licochalcone B  (ISO)
Liensinine  (ISO)
lignan  (ISO)
limonin  (ISO)
linalool  (EXP)
linoleic acid  (EXP,ISO)
linuron  (ISO)
lipoic acid  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
lipoteichoic acid  (EXP)
lipoxin A4  (ISO)
liquiritin  (ISO)
liraglutide  (ISO)
lithium atom  (ISO)
lithium carbonate  (ISO)
lithium chloride  (EXP,ISO)
lithium hydride  (ISO)
lithocholic acid  (ISO)
loganin  (EXP,ISO)
lonafarnib  (ISO)
lonidamine  (ISO)
lopinavir  (ISO)
lorcaserin  (ISO)
lovastatin  (ISO)
lumiracoxib  (ISO)
lupeol  (ISO)
luteolin  (EXP,ISO)
LY294002  (EXP,ISO)
lycopene  (ISO)
lysophosphatidylcholine  (ISO)
madecassoside  (ISO)
magnesium atom  (EXP)
magnesium dihydroxide  (ISO)
magnesium sulfate  (ISO)
Magnolol  (EXP)
malathion  (EXP,ISO)
malonaldehyde  (ISO)
malvidin  (ISO)
mancozeb  (ISO)
maneb  (EXP,ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
mangiferin  (EXP,ISO)
manoalide  (ISO)
manumycin A  (ISO)
masoprocol  (ISO)
mebendazole  (ISO)
Mecamylamine  (ISO)
mechlorethamine  (ISO)
medroxyprogesterone acetate  (ISO)
mefenamic acid  (ISO)
MeIQx  (ISO)
melatonin  (EXP,ISO)
melittin  (EXP,ISO)
meloxicam  (ISO)
melphalan  (ISO)
memantine  (ISO)
menadione  (EXP)
menaquinone  (ISO)
mepanipyrim  (ISO)
mephedrone  (EXP)
mercury atom  (ISO)
mercury dichloride  (EXP,ISO)
mercury(0)  (ISO)
mesalamine  (EXP,ISO)
metam  (ISO)
metamizole sodium  (EXP)
metaproterenol  (ISO)
metformin  (EXP,ISO)
methadone  (EXP)
methamphetamine  (EXP,ISO)
Methanandamide  (ISO)
methanol  (ISO)
methapyrilene  (EXP)
methimazole  (EXP)
methotrexate  (EXP,ISO)
methoxychlor  (EXP,ISO)
methyl methacrylate  (ISO)
Methyl palmitate  (EXP)
methylglyoxal  (EXP,ISO)
methylisothiazolinone  (ISO)
methyllycaconitine  (EXP,ISO)
methylmalonic acid  (EXP)
methylmercury chloride  (EXP)
methylphenidate  (EXP)
metronidazole  (ISO)
mevalonic acid  (ISO)
mevastatin  (ISO)
microcystin-LR  (EXP,ISO)
mifepristone  (EXP,ISO)
Miglitol  (EXP,ISO)
minocycline  (EXP,ISO)
miquelianin  (EXP)
mirtazapine  (EXP)
misoprostol  (ISO)
mitomycin C  (ISO)
Mizoribine  (ISO)
MJN110  (ISO)
MK 571  (ISO)
MK-2206  (EXP,ISO)
Mofezolac (TN)  (ISO)
molybdenum trichloride  (ISO)
mometasone furoate  (ISO)
monascin  (EXP,ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Monobutylphthalate  (ISO)
monocrotaline  (EXP,ISO)
Monocyte locomotion inhibitory factor  (ISO)
monosodium L-glutamate  (EXP)
monotropein  (ISO)
montelukast  (EXP,ISO)
morin  (EXP,ISO)
morphine  (EXP,ISO)
Morphine-3-glucuronide  (EXP,ISO)
Morroniside  (EXP,ISO)
Moxestrol  (ISO)
moxifloxacin  (ISO)
Muraglitazar  (EXP)
muramyl dipeptide  (ISO)
mycotoxin  (ISO)
myo-inositol hexakisphosphate  (ISO)
myrtenol  (EXP)
N(5)-ethyl-L-glutamine  (EXP)
N(gamma)-nitro-L-arginine methyl ester  (EXP,ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N,N-diethyl-m-toluamide  (EXP,ISO)
N,N-dimethylformamide  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP,ISO)
N-[2-(diethylamino)ethyl]-2-methoxy-5-methylsulfonylbenzamide  (EXP)
N-[3-(aminomethyl)benzyl]acetamidine  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-acetylsphingosine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (ISO)
N-hexadecanoylsphingosine  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-methyl-N-nitrosourea  (EXP,ISO)
N-methylnicotinate  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP,ISO)
N-tosyl-L-phenylalanyl chloromethyl ketone  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
NAD zwitterion  (ISO)
NAD(+)  (ISO)
nafcillin  (ISO)
nalidixic acid  (ISO)
naloxone  (ISO)
naproxen  (EXP,ISO)
naringin  (EXP,ISO)
nefazodone  (ISO)
Neferine  (EXP)
nelfinavir  (ISO)
neoastilbin  (ISO)
neoechinulin A  (ISO)
Neoisoliquiritin  (ISO)
neomycin  (ISO)
nevirapine  (ISO)
nickel atom  (EXP,ISO)
nickel dichloride  (EXP,ISO)
nickel sulfate  (EXP,ISO)
niclosamide  (ISO)
nicorandil  (EXP)
nicotinamide  (EXP,ISO)
nicotine  (EXP,ISO)
nicotinic acid  (ISO)
nifedipine  (ISO)
nigericin  (ISO)
nilotinib  (EXP,ISO)
nimesulide  (EXP,ISO)
nitrates  (ISO)
nitric oxide  (EXP,ISO)
nitrites  (EXP,ISO)
nitroflurbiprofen  (EXP)
nitrofurazone  (ISO)
nitrogen dioxide  (EXP,ISO)
nitroglycerin  (EXP)
nitroprusside  (EXP,ISO)
nitrososulfamethoxazole  (ISO)
Nivalenol  (ISO)
NMN zwitterion  (EXP,ISO)
nobiletin  (EXP)
nocodazole  (ISO)
nonanoic acid  (ISO)
Nonylphenol  (EXP,ISO)
Nookatone  (EXP)
norfloxacin  (EXP,ISO)
norlaudanosoline  (ISO)
notoginsenoside R1  (EXP,ISO)
NS-398  (EXP,ISO)
NSC 23766  (ISO)
nystatin  (ISO)
O-acetyl-L-carnitine  (EXP)
o-anisidine  (ISO)
O-methyleugenol  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (EXP,ISO)
octanoic acid  (ISO)
ofloxacin  (ISO)
okadaic acid  (EXP,ISO)
olanzapine  (ISO)
olaparib  (ISO)
oleanolic acid  (ISO)
oleic acid  (EXP,ISO)
Olmesartan medoxomil  (EXP)
omeprazole  (EXP)
Ondansetron  (EXP)
orciprenaline  (ISO)
organoselenium compound  (EXP)
oridonin  (EXP)
orlistat  (EXP)
oroxylin A  (EXP,ISO)
oxaliplatin  (EXP)
oxidopamine  (EXP,ISO)
oxybutynin  (ISO)
ozone  (EXP,ISO)
p-cresol  (ISO)
p-menthan-3-ol  (ISO)
p-tolualdehyde  (ISO)
paclitaxel  (EXP,ISO)
paeoniflorin  (EXP,ISO)
Paeonol  (EXP,ISO)
Palbinone  (EXP)
paliperidone palmitate  (ISO)
palmatine  (EXP,ISO)
Palmitic acid(d3)  (ISO)
pamidronate  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parathion  (ISO)
parathion-methyl  (ISO)
paricalcitol  (ISO)
paroxetine  (ISO)
parthenolide  (ISO)
patulin  (ISO)
pazopanib  (ISO)
PD 0325901  (ISO)
penbutolol  (ISO)
pentachlorophenol  (ISO)
pentamidine  (ISO)
pentetic acid  (ISO)
pentobarbital  (EXP,ISO)
Pentoxifylline  (EXP,ISO)
peptidoglycan  (EXP,ISO)
perampanel  (EXP)
perfluorobutyric acid  (ISO)
perfluorodecanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
perindopril  (EXP,ISO)
permethrin  (EXP,ISO)
peroxides  (EXP)
pevonedistat  (ISO)
pexidartinib  (ISO)
PGI3  (ISO)
Phellodendrine  (EXP)
phenanthridone  (EXP)
Phenelzine  (ISO)
phenethyl caffeate  (EXP,ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (EXP,ISO)
phenol  (EXP,ISO)
phenylarsine oxide  (ISO)
phenylephrine  (EXP)
phenytoin  (ISO)
PhIP  (EXP,ISO)
phloretin  (ISO)
phlorizin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosalone  (EXP)
phosgene  (EXP)
phosphatidic acid  (ISO)
phosphatidylcholine  (ISO)
phosphoramide mustard  (EXP)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
phoxim  (EXP)
phthalaldehyde  (ISO)
physostigmine  (ISO)
phytoestrogen  (ISO)
Phytolaccoside E  (ISO)
piclamilast  (EXP)
picropodophyllotoxin  (ISO)
pimobendan  (ISO)
pinitol  (EXP,ISO)
pinostrobin  (EXP)
pioglitazone  (EXP,ISO)
piperacillin  (EXP)
piperazine  (ISO)
piperine  (ISO)
piperonyl butoxide  (ISO)
Pirarubicin  (EXP)
pirfenidone  (ISO)
pirinixic acid  (EXP,ISO)
pirprofen  (ISO)
platycodin D  (EXP,ISO)
pluronic P-123  (ISO)
Poloxamer  (ISO)
Polpunonic acid  (ISO)
poly(cytidylic acid)  (EXP)
poly(ethylene)  (ISO)
poly(I:C)  (EXP,ISO)
polymyxin B2  (ISO)
Potassium 2,6-dihydroxytriazinecarboxylate  (EXP,ISO)
potassium atom  (ISO)
potassium bromate  (EXP,ISO)
potassium chloride  (EXP,ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
Praeruptorin A  (ISO)
pravastatin  (EXP,ISO)
prednisolone  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
PRIM-O-GLUCOSYLCIMIFUGIN  (EXP,ISO)
primaquine  (ISO)
proanthocyanidin  (EXP)
probucol  (EXP)
procaterol  (EXP)
procyanidin B2  (EXP)
procyanidin B3  (ISO)
procyclidine  (ISO)
procymidone  (ISO)
prodigiosin  (EXP)
progesterone  (EXP,ISO)
promethazine  (EXP)
propamocarb  (ISO)
propiconazole  (EXP,ISO)
propionic acid  (EXP,ISO)
propofol  (ISO)
propranolol  (EXP,ISO)
prostaglandin D2  (EXP,ISO)
prostaglandin D3  (ISO)
prostaglandin E2  (EXP,ISO)
prostaglandin E3  (ISO)
prostaglandin F2alpha  (ISO)
prostaglandin I2  (EXP)
protein kinase inhibitor  (ISO)
prunetin  (ISO)
pterostilbene  (ISO)
puerarin  (ISO)
Punicalagin  (EXP)
purmorphamine  (EXP)
Pyridostigmine bromide  (EXP,ISO)
pyrimethanil  (ISO)
pyrrolidine dithiocarbamate  (EXP,ISO)
pyrvinium  (EXP)
quartz  (ISO)
quercetagetin  (EXP)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (EXP)
quercetin 3-O-beta-D-glucopyranoside  (EXP)
quercitrin  (EXP)
quinazolines  (ISO)
quinolinic acid  (EXP)
radicicol  (EXP)
raloxifene  (EXP,ISO)
ramipril  (EXP)
ranitidine  (EXP)
Ranitidine bismuth citrate  (ISO)
raspberry ketone  (EXP)
reactive oxygen species  (ISO)
remdesivir  (ISO)
Repaglinide  (EXP)
reparixin  (ISO)
resiniferatoxin  (ISO)
resiquimod  (ISO)
resolvin D1  (ISO)
resolvin D2  (ISO)
resorcinol  (ISO)
resveratrol  (EXP,ISO)
Rhein  (ISO)
Rhynchophylline  (EXP)
ribavirin  (ISO)
riboflavin  (ISO)
rifampicin  (EXP,ISO)
rimonabant  (ISO)
rivaroxaban  (EXP)
Rizatriptan benzoate  (EXP)
Ro 31-8220  (ISO)
rofecoxib  (EXP,ISO)
roflumilast  (EXP)
rolipram  (EXP,ISO)
ropinirole  (EXP)
Roridin A  (ISO)
rosmarinic acid  (EXP,ISO)
rosuvastatin calcium  (EXP)
rotenone  (EXP,ISO)
Ruscogenin  (ISO)
Rutecarpine  (ISO)
rutin  (EXP,ISO)
ruxolitinib  (ISO)
ryanodine  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-adenosyl-L-methioninate  (EXP,ISO)
S-adenosyl-L-methionine  (EXP,ISO)
S-allylcysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP,ISO)
salicylates  (EXP)
salicylic acid  (ISO)
Salidroside  (EXP,ISO)
Salmeterol xinafoate  (ISO)
salubrinal  (ISO)
Salvianolic acid A  (EXP)
salvianolic acid B  (EXP,ISO)
Sanggenon C  (EXP)
sarin  (EXP,ISO)
saroglitazar  (ISO)
sarpogrelate  (ISO)
SB 203580  (EXP,ISO)
SB 206553  (ISO)
SC-58125  (ISO)
scalaradial  (ISO)
scoparone  (ISO)
scopolamine  (EXP,ISO)
selenium atom  (EXP,ISO)
senecionine  (ISO)
serotonin  (ISO)
serpentine asbestos  (EXP,ISO)
Sesamol  (ISO)
sevoflurane  (EXP,ISO)
Shikonin  (ISO)
silibinin  (ISO)
silicon atom  (EXP)
silicon dioxide  (EXP,ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
silver(1+) nitrate  (ISO)
silychristin  (ISO)
simvastatin  (EXP,ISO)
sinapic acid  (EXP,ISO)
sincalide  (EXP)
Sinomenine  (ISO)
sirolimus  (EXP,ISO)
sirtinol  (ISO)
SL-327  (EXP)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
sodium atom  (ISO)
sodium aurothiomalate  (ISO)
sodium azide  (EXP)
sodium benzoate  (EXP)
sodium chloride  (ISO)
sodium cholate  (EXP,ISO)
sodium chromate  (ISO)
sodium dichromate  (EXP,ISO)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (EXP,ISO)
sodium hydroxide  (ISO)
sodium nitrite  (EXP,ISO)
Sodium oleate  (ISO)
Sodium salicylate  (ISO)
sodium stibogluconate  (ISO)
solasodine  (EXP)
Soman  (EXP,ISO)
sorafenib  (ISO)
sotorasib  (ISO)
soyasaponin I  (ISO)
sphingosine 1-phosphate  (ISO)
spironolactone  (ISO)
SR 144528  (ISO)
stattic  (ISO)
stavudine  (ISO)
sterigmatocystin  (ISO)
streptozocin  (EXP,ISO)
strychnine  (ISO)
styrene  (ISO)
succimer  (ISO)
Sucralfate  (ISO)
sulfamethizole  (ISO)
sulfasalazine  (EXP,ISO)
sulfonyldimethane  (EXP)
sulforaphane  (EXP,ISO)
sulfoxaflor  (EXP)
sulfur dioxide  (EXP)
sulindac  (EXP,ISO)
Sulpyrine  (EXP)
sumatriptan  (EXP)
sunitinib  (EXP)
superoxide  (ISO)
surfactin  (ISO)
surfactin C  (ISO)
T-2 toxin  (EXP,ISO)
tacrine  (ISO)
tacrolimus hydrate  (ISO)
tadalafil  (EXP,ISO)
Talc  (ISO)
tamibarotene  (ISO)
tamoxifen  (EXP,ISO)
tangeretin  (EXP)
Tanshinone I  (ISO)
taurine  (EXP,ISO)
taurocholic acid  (EXP,ISO)
tauroursodeoxycholic acid  (ISO)
tazobactam  (EXP)
telmisartan  (EXP,ISO)
tenofovir disoproxil fumarate  (EXP)
terbutaline  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP)
testosterone  (EXP,ISO)
testosterone enanthate  (EXP)
Testosterone propionate  (ISO)
tetrachloro-1,4-benzoquinone  (ISO)
Tetrachlorobisphenol A  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
tetrafluoroethene  (ISO)
tetralin  (ISO)
tetraphene  (ISO)
tetrathiomolybdate(2-)  (ISO)
thalidomide  (EXP,ISO)
thapsigargin  (EXP,ISO)
Theaflavin 3,3'-digallate  (EXP,ISO)
theophylline  (EXP,ISO)
thiacloprid  (EXP)
thiamethoxam  (EXP)
thiamine(1+) chloride  (EXP)
thiazoles  (EXP)
thioacetamide  (EXP,ISO)
thiopental  (EXP)
thiostrepton  (ISO)
thiram  (ISO)
thromboxane B2  (ISO)
thymol  (ISO)
thymol sulfate(1-)  (ISO)
thymoquinone  (EXP,ISO)
thyroxine  (ISO)
tienilic acid  (ISO)
tigecycline  (EXP,ISO)
Timosaponin b ii  (ISO)
tipifarnib  (ISO)
Tiron  (ISO)
titanium atom  (EXP,ISO)
titanium dioxide  (EXP,ISO)
TMC-120A  (ISO)
tofacitinib  (EXP,ISO)
tolterodine tartrate  (ISO)
toluene  (EXP)
toluene 2,4-diisocyanate  (ISO)
Tomentosin  (ISO)
topotecan  (EXP)
toyocamycin  (ISO)
trametinib  (ISO)
trans-anethole  (EXP)
trans-caffeic acid  (EXP,ISO)
trans-ferulic acid  (EXP,ISO)
trans-piceid  (EXP)
trazodone  (ISO)
trelagliptin  (ISO)
tremolite asbestos  (ISO)
triamcinolone acetonide  (ISO)
tribromoethanol  (EXP)
tributylstannane  (ISO)
tributyrin  (ISO)
trichloroacetic acid  (EXP,ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclocarban  (EXP)
triclosan  (ISO)
Trihexyphenidyl  (ISO)
trilobatin  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
troglitazone  (EXP,ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
tropisetron  (EXP,ISO)
trovafloxacin  (ISO)
Tryptanthrine  (ISO)
tubocurarine  (ISO)
tungsten  (EXP,ISO)
Tungsten carbide  (ISO)
tunicamycin  (EXP,ISO)
U-73122  (ISO)
ubiquinone-0  (ISO)
ubiquinones  (ISO)
umbelliferone  (EXP)
undecan-2-one  (EXP,ISO)
uranium atom  (EXP,ISO)
urethane  (EXP,ISO)
ursodeoxycholic acid  (EXP,ISO)
ursolic acid  (EXP)
usnic acid  (ISO)
valproic acid  (EXP,ISO)
valsartan  (EXP)
vanadyl sulfate  (ISO)
vancomycin  (ISO)
vanillin  (ISO)
varespladib methyl  (ISO)
veliparib  (ISO)
venom  (ISO)
verbascose  (ISO)
vincaleukoblastine  (EXP,ISO)
vincamine  (ISO)
vinclozolin  (EXP)
vincristine  (EXP,ISO)
Vinpocetine  (ISO)
vitamin E  (EXP,ISO)
vitamin K  (EXP)
vorinostat  (ISO)
VX-745  (ISO)
warfarin  (EXP,ISO)
water  (EXP,ISO)
wedelolactone  (EXP)
WIN 55212-2  (EXP,ISO)
withaferin A  (ISO)
wogonin  (EXP,ISO)
wortmannin  (ISO)
Xanthatin  (ISO)
xanthohumol  (ISO)
XL147  (ISO)
xyloglucan  (ISO)
Y-27632  (ISO)
Yangonin  (ISO)
zafirlukast  (ISO)
zaragozic acid A  (EXP,ISO)
zearalenone  (EXP,ISO)
zerumbone  (ISO)
zidovudine  (ISO)
zileuton  (ISO)
zinc acetate  (EXP)
zinc atom  (EXP,ISO)
zinc dichloride  (EXP,ISO)
zinc molecular entity  (ISO)
zinc oxide  (EXP,ISO)
zinc protoporphyrin  (EXP,ISO)
zinc sulfate  (EXP,ISO)
zinc(0)  (EXP,ISO)
zingerone  (EXP)
zingiberene  (EXP)
ziram  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
astrocyte activation  (IEA,ISO)
cellular response to antibiotic  (IEP)
cellular response to fatty acid  (IEP)
cellular response to glucose stimulus  (IEP)
cellular response to interleukin-17  (IEA,ISO)
cellular response to lipid  (IEP)
cellular response to lipopolysaccharide  (IBA,IEP)
cellular response to mechanical stimulus  (ISO)
cellular response to xenobiotic stimulus  (ISO)
chronic inflammatory response to antigenic stimulus  (IEP)
cytokine-mediated signaling pathway  (IBA,ISO)
defense response to Gram-positive bacterium  (ISO)
ectopic germ cell programmed cell death  (IEA,ISO)
extrinsic apoptotic signaling pathway in absence of ligand  (IEA,ISO)
fever generation  (IEA,IEP)
hyaluronan biosynthetic process  (ISO)
immune response  (IEA)
inflammatory response  (IBA,ISO)
interleukin-1-mediated signaling pathway  (ISO)
JNK cascade  (IEA,ISO)
learning or memory  (IEP)
leukocyte migration  (ISO)
memory  (IMP)
monocyte aggregation  (ISO)
negative regulation of adiponectin secretion  (IEA,ISO)
negative regulation of branching morphogenesis of a nerve  (IDA)
negative regulation of cell population proliferation  (ISO)
negative regulation of D-glucose transmembrane transport  (IEA,ISO)
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
negative regulation of gap junction assembly  (ISO)
negative regulation of gene expression  (IDA)
negative regulation of glutamate secretion  (IMP)
negative regulation of insulin receptor signaling pathway  (IEA,ISO)
negative regulation of lipid catabolic process  (ISO)
negative regulation of lipid metabolic process  (IEA,ISO)
negative regulation of MAP kinase activity  (ISO)
negative regulation of neural precursor cell proliferation  (IDA)
negative regulation of neurogenesis  (IDA)
negative regulation of neuron differentiation  (IDA)
negative regulation of synaptic transmission  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IDA)
neutrophil chemotaxis  (IEA,ISO)
positive regulation of angiogenesis  (IEA,ISO)
positive regulation of apoptotic process  (IDA,IMP)
positive regulation of astrocyte differentiation  (IDA)
positive regulation of calcidiol 1-monooxygenase activity  (ISO)
positive regulation of canonical NF-kappaB signal transduction  (IDA,IEA,ISO)
positive regulation of cell division  (IEA)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of chemokine production  (IEA,ISO)
positive regulation of complement activation  (ISO)
positive regulation of cytokine production  (IEA)
positive regulation of cytosolic calcium ion concentration  (IDA)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of epithelial to mesenchymal transition  (ISO)
positive regulation of ERK1 and ERK2 cascade  (IDA)
positive regulation of fever generation  (IEA,ISO)
positive regulation of gene expression  (IBA,IDA,ISO)
positive regulation of glial cell differentiation  (IDA)
positive regulation of glial cell proliferation  (ISO)
positive regulation of granulocyte macrophage colony-stimulating factor production  (ISO)
positive regulation of heterotypic cell-cell adhesion  (ISO)
positive regulation of immature T cell proliferation in thymus  (IBA,IDA)
positive regulation of inflammatory response  (ISO)
positive regulation of interleukin-2 production  (ISO)
positive regulation of interleukin-6 production  (IDA,IEA,ISO)
positive regulation of interleukin-8 production  (ISO)
positive regulation of JNK cascade  (IDA,IEA,ISO)
positive regulation of JUN kinase activity  (IMP)
positive regulation of lipid catabolic process  (IEA,ISO)
positive regulation of MAP kinase activity  (ISO)
positive regulation of membrane protein ectodomain proteolysis  (ISO)
positive regulation of mitotic nuclear division  (ISO)
positive regulation of monocyte chemotactic protein-1 production  (ISO)
positive regulation of neuron apoptotic process  (IMP)
positive regulation of neutrophil chemotaxis  (IMP)
positive regulation of NF-kappaB transcription factor activity  (ISO)
positive regulation of nitric oxide biosynthetic process  (ISO)
positive regulation of non-canonical NF-kappaB signal transduction  (ISO)
positive regulation of p38MAPK cascade  (IEA,ISO)
positive regulation of prostaglandin biosynthetic process  (ISO)
positive regulation of prostaglandin secretion  (IEA,ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of RNA biosynthetic process  (ISO)
positive regulation of stress-activated MAPK cascade  (IDA,IMP)
positive regulation of T cell proliferation  (ISO)
positive regulation of T-helper 1 cell cytokine production  (ISO,ISS)
positive regulation of tight junction disassembly  (ISO)
positive regulation of transcription by RNA polymerase II  (IDA,IEA,ISO)
positive regulation of type II interferon production  (ISO,ISS)
positive regulation of vascular endothelial growth factor production  (IEA,ISO)
regulation of canonical NF-kappaB signal transduction  (ISO)
regulation of defense response to virus by host  (IEA,ISO)
regulation of ERK1 and ERK2 cascade  (ISO)
regulation of establishment of endothelial barrier  (ISO)
regulation of insulin secretion  (ISO)
regulation of neurogenesis  (IGI)
regulation of nitric-oxide synthase activity  (ISO)
response to ATP  (IEA,ISO)
response to carbohydrate  (IEA,ISO)
response to dexamethasone  (IEP)
response to estradiol  (IEP)
response to ethanol  (IEP)
response to gamma radiation  (IEP)
response to glucocorticoid  (IEP)
response to hypoxia  (IEP)
response to immobilization stress  (IEP)
response to interleukin-1  (ISO)
response to isolation stress  (IEP)
response to L-ascorbic acid  (IEP)
response to lipopolysaccharide  (IEA,IEP,ISO)
response to nutrient  (IEP)
response to organic cyclic compound  (IEP)
response to ozone  (IEP)
response to peptide hormone  (IEP)
response to stilbenoid  (IEP)
response to vitamin D  (IEP)
response to xenobiotic stimulus  (IEP)
sequestering of triglyceride  (ISO)
signal transduction  (IEA)
social behavior  (IMP)
vascular endothelial growth factor production  (ISO,ISS)

Cellular Component
cytosol  (IEA)
extracellular region  (ISO)
extracellular space  (IBA,IDA,IEA,ISO)
lysosome  (IEA)
secretory granule  (IEA,ISO)
vesicle  (ISO)

Molecular Function

References

References - curated
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374. Knockdown of lncRNA H19 alleviates ox-LDL-induced HCAECs inflammation and injury by mediating miR-20a-5p/HDAC4 axis. Yang Y, etal., Inflamm Res. 2022 Sep;71(9):1109-1121. doi: 10.1007/s00011-022-01604-z. Epub 2022 Jul 19.
375. Mutations in the ELANE gene are associated with development of periodontitis in patients with severe congenital neutropenia. Ye Y, etal., J Clin Immunol. 2011 Dec;31(6):936-45. doi: 10.1007/s10875-011-9572-0. Epub 2011 Jul 29.
376. Interleukin-1beta mediates sleep alteration in rats with rotenone-induced parkinsonism. Yi PL, etal., Sleep. 2007 Apr 1;30(4):413-25.
377. Phosphodiesterase-5 inhibition by sildenafil citrate in a rat model of bleomycin-induced lung fibrosis. Yildirim A, etal., Pulm Pharmacol Ther. 2010 Jun;23(3):215-21. Epub 2009 Nov 27.
378. Relationship between serum interleukin-1beta levels and acute phase response proteins in patients with familial Mediterranean fever. Yildirim K, etal., Biochem Med (Zagreb). 2012;22(1):109-13.
379. Interleukin-1beta Promoter Polymorphism Enhances the Risk of Sleep Disturbance in Alzheimer's Disease. Yin Y, etal., PLoS One. 2016 Mar 3;11(3):e0149945. doi: 10.1371/journal.pone.0149945. eCollection 2016.
380. Interleukin-1 alpha, interleukin-1 beta, and tumor necrosis factor gene expression in endotoxin-induced uveitis. Yoshida M, etal., Invest Ophthalmol Vis Sci. 1994 Mar;35(3):1107-13.
381. Inhibition of Poly(ADP-Ribose) Polymerase Attenuates Acute Kidney Injury in Sodium Taurocholate-Induced Acute Pancreatitis in Rats. Yu J, etal., Pancreas. 2012 Nov;41(8):1299-305. doi: 10.1097/MPA.0b013e318252dbc3.
382. Pregnane X Receptor Not Nuclear Factor-kappa B Up-regulates P-glycoprotein Expression in the Brain of Chronic Epileptic Rats Induced by Kainic Acid. Yu N, etal., Neurochem Res. 2017 Aug;42(8):2167-2177. doi: 10.1007/s11064-017-2224-x. Epub 2017 Mar 16.
383. Local Induction of B Cell Interleukin-10 Competency Alleviates Inflammation and Bone Loss in Ligature-Induced Experimental Periodontitis in Mice. Yu P, etal., Infect Immun. 2016 Dec 29;85(1). pii: IAI.00645-16. doi: 10.1128/IAI.00645-16. Print 2017 Jan.
384. Akebia Saponin D attenuates amyloid beta-induced cognitive deficits and inflammatory response in rats: involvement of Akt/NF-kappaB pathway. Yu X, etal., Behav Brain Res. 2012 Dec 1;235(2):200-9. doi: 10.1016/j.bbr.2012.07.045. Epub 2012 Aug 8.
385. Effect of loss of bite force on interleukin-1beta expression in rat periodontium. Yuan L and Zhou WD, Di Yi Jun Yi Da Xue Xue Bao 2002 Oct;22(10):925-7.
386. Association of interleukin-1beta and interleukin-1 receptor antagonist gene polymorphisms in Turkish children with atopic asthma. Zeyrek D, etal., Allergy Asthma Proc. 2008 Sep-Oct;29(5):468-74.
387. Early gestational intrauterine infection induces postnatal lung inflammation and arrests lung development in a rat model. Zhan CY, etal., J Matern Fetal Neonatal Med. 2010 May 17.
388. Activation of Nod-like receptor protein 3 inflammasomes turns on podocyte injury and glomerular sclerosis in hyperhomocysteinemia. Zhang C, etal., Hypertension. 2012 Jul;60(1):154-62. Epub 2012 May 29.
389. Gene expression profile related to inflammation in rat model of traumatic deep vein thrombosis. Zhang CQ, etal., Chin J Traumatol. 2007 Aug;10(4):206-12.
390. The effects of inflammation on lipid accumulation in the kidneys of children with primary nephrotic syndrome. Zhang G, etal., Inflammation. 2011 Dec;34(6):645-52.
391. Exosome-mediated targeted delivery of miR-210 for angiogenic therapy after cerebral ischemia in mice. Zhang H, etal., J Nanobiotechnology. 2019 Feb 19;17(1):29. doi: 10.1186/s12951-019-0461-7.
392. Protective effects of sinomenine against doxorubicin-induced nephrosis in rats. Zhang J, etal., J Asian Nat Prod Res. 2012;14(7):678-87. doi: 10.1080/10286020.2012.685070. Epub 2012 May 15.
393. OTUB1 overexpression in mesangial cells is a novel regulator in the pathogenesis of glomerulonephritis through the decrease of DCN level. Zhang Y, etal., PLoS One. 2012;7(1):e29654. Epub 2012 Jan 18.
394. Therapeutic Effects of Cortex acanthopanacis Aqueous Extract on Bone Metabolism of Ovariectomized Rats. Zhang Z, etal., Evid Based Complement Alternat Med. 2012;2012:492627. Epub 2012 Sep 11.
395. Improved outcome of EAN, an animal model of GBS, through amelioration of peripheral and central inflammation by minocycline. Zhang ZY, etal., J Cell Mol Med. 2009 Feb;13(2):341-51. doi: 10.1111/j.1582-4934.2008.00333.x. Epub 2008 Apr 8.
396. Effect of Ginkgo leaf parenteral solution on blood and cochlea antioxidant and immunity indexes in OM rats. Zhao J, etal., Molecules. 2011 Dec 15;16(12):10433-42. doi: 10.3390/molecules161210433.
397. Altered biliary epithelial cell and monocyte responses to lipopolysaccharide as a TLR ligand in patients with primary biliary cirrhosis. Zhao J, etal., Scand J Gastroenterol. 2011 Apr;46(4):485-94. doi: 10.3109/00365521.2010.539624. Epub 2011 Jan 28.
398. IL-10-592 polymorphism is associated with IL-10 expression and severity of enterovirus 71 infection in chinese children. Zhao N, etal., J Clin Virol. 2017 Oct;95:42-46. doi: 10.1016/j.jcv.2017.08.005. Epub 2017 Aug 19.
399. Protective effect of dioscin against thioacetamide-induced acute liver injury via FXR/AMPK signaling pathway in vivo. Zheng L, etal., Biomed Pharmacother. 2018 Jan;97:481-488. doi: 10.1016/j.biopha.2017.10.153. Epub 2017 Nov 6.
400. Long-Term Binge and Escalating Ethanol Exposure Causes Necroinflammation and Fibrosis in Rat Liver. Zhou JY, etal., Alcohol Clin Exp Res. 2012 Sep 25. doi: 10.1111/j.1530-0277.2012.01936.x.
401. Dexamethasone pretreatment attenuates lung and kidney injury in cholestatic rats induced by hepatic ischemia/reperfusion. Zhou L, etal., Inflammation. 2012 Feb;35(1):289-96.
402. Ghrelin attenuates acute pancreatitis-induced lung injury and inhibits substance P expression. Zhou X and Xue C, Am J Med Sci. 2010 Jan;339(1):49-54.
403. Protective effects of Huang Qi Huai granules on adriamycin nephrosis in rats. Zhu C, etal., Pediatr Nephrol. 2011 Jun;26(6):905-13. Epub 2011 Feb 27.
404. The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-α. Zhu S, etal., Nat Med. 2012 Jul;18(7):1077-86. doi: 10.1038/nm.2815.
405. Plasma cytokines profile in older subjects with late onset Alzheimer's disease or vascular dementia. Zuliani G, etal., J Psychiatr Res. 2007 Oct;41(8):686-93. Epub 2006 Apr 4.
Additional References at PubMed
PMID:1752215   PMID:1919436   PMID:2989698   PMID:3493774   PMID:8383325   PMID:10383454   PMID:10653850   PMID:10748004   PMID:11016935   PMID:11090614   PMID:11168643   PMID:11536012  
PMID:11793965   PMID:11930180   PMID:12054592   PMID:12091394   PMID:12139924   PMID:12182417   PMID:12231480   PMID:12392281   PMID:12477932   PMID:12483741   PMID:12531724   PMID:12598651  
PMID:12694391   PMID:12707357   PMID:12794041   PMID:12864980   PMID:12874323   PMID:12925700   PMID:12950323   PMID:12957790   PMID:12958148   PMID:12960020   PMID:14500723   PMID:14507968  
PMID:14525971   PMID:14572767   PMID:14575314   PMID:14581482   PMID:14597101   PMID:14615050   PMID:14651966   PMID:14652719   PMID:14684367   PMID:15034066   PMID:15085088   PMID:15100360  
PMID:15115662   PMID:15147725   PMID:15172111   PMID:15191814   PMID:15283957   PMID:15292196   PMID:15304373   PMID:15316242   PMID:15319424   PMID:15476580   PMID:15551000   PMID:15591777  
PMID:15622524   PMID:15694370   PMID:15713269   PMID:15755725   PMID:15773230   PMID:15808840   PMID:15843532   PMID:15882780   PMID:15883745   PMID:15899045   PMID:15905573   PMID:15932594  
PMID:15950780   PMID:16040592   PMID:16081876   PMID:16083355   PMID:16106045   PMID:16189509   PMID:16238458   PMID:16260493   PMID:16301672   PMID:16325304   PMID:16341933   PMID:16371439  
PMID:16423834   PMID:16427196   PMID:16547818   PMID:16567807   PMID:16575408   PMID:16626814   PMID:16707097   PMID:16720358   PMID:16720713   PMID:16762003   PMID:16802110   PMID:16822942  
PMID:16823390   PMID:16830232   PMID:16848226   PMID:16887357   PMID:16887807   PMID:16972262   PMID:17018336   PMID:17023519   PMID:17036048   PMID:17076768   PMID:17137520   PMID:17158358  
PMID:17166735   PMID:17170234   PMID:17184753   PMID:17196563   PMID:17234889   PMID:17386088   PMID:17407761   PMID:17419800   PMID:17442043   PMID:17449272   PMID:17467122   PMID:17486449  
PMID:17505309   PMID:17505802   PMID:17602892   PMID:17689191   PMID:17822921   PMID:17874178   PMID:17881497   PMID:17884764   PMID:17912642   PMID:17914961   PMID:17916651   PMID:17920716  
PMID:17959986   PMID:17989112   PMID:17996195   PMID:17997277   PMID:18032781   PMID:18036576   PMID:18059318   PMID:18073507   PMID:18073510   PMID:18171908   PMID:18178625   PMID:18182231  
PMID:18201371   PMID:18288929   PMID:18299267   PMID:18299269   PMID:18304357   PMID:18323732   PMID:18373975   PMID:18390750   PMID:18421573   PMID:18431565   PMID:18443542   PMID:18455872  
PMID:18463842   PMID:18470577   PMID:18487441   PMID:18490713   PMID:18500427   PMID:18511291   PMID:18535404   PMID:18535786   PMID:18541537   PMID:18554806   PMID:18559338   PMID:18563316  
PMID:18598258   PMID:18632279   PMID:18664380   PMID:18675261   PMID:18687386   PMID:18700232   PMID:18752652   PMID:18821705   PMID:18841529   PMID:18848809   PMID:19022682   PMID:19032770  
PMID:19041259   PMID:19109696   PMID:19151248   PMID:19158679   PMID:19180878   PMID:19183878   PMID:19193853   PMID:19235895   PMID:19326443   PMID:19349674   PMID:19359664   PMID:19362079  
PMID:19398497   PMID:19473768   PMID:19524870   PMID:19534684   PMID:19537852   PMID:19592596   PMID:19593445   PMID:19609086   PMID:19655406   PMID:19666510   PMID:19666548   PMID:19722154  
PMID:19723085   PMID:19734906   PMID:19743505   PMID:19774496   PMID:19816055   PMID:19841289   PMID:19861503   PMID:19882666   PMID:19900553   PMID:19940926   PMID:19951488   PMID:19958762  
PMID:20004705   PMID:20018936   PMID:20027291   PMID:20034811   PMID:20035858   PMID:20041150   PMID:20108347   PMID:20371087   PMID:20380881   PMID:20420568   PMID:20454616   PMID:20529813  
PMID:20554964   PMID:20625799   PMID:20658183   PMID:20702406   PMID:20736890   PMID:20739563   PMID:20855265   PMID:20883789   PMID:20926198   PMID:20939479   PMID:20969918   PMID:20970480  
PMID:20977842   PMID:21053877   PMID:21092452   PMID:21093329   PMID:21098642   PMID:21115202   PMID:21147091   PMID:21167894   PMID:21199478   PMID:21244430   PMID:21265103   PMID:21354239  
PMID:21394197   PMID:21443890   PMID:21470686   PMID:21494199   PMID:21555119   PMID:21559518   PMID:21621857   PMID:21681347   PMID:21685693   PMID:21708940   PMID:21719118   PMID:21745542  
PMID:21846367   PMID:21949132   PMID:22033365   PMID:22036618   PMID:22144718   PMID:22213141   PMID:22229265   PMID:22266391   PMID:22281445   PMID:22358087   PMID:22466130   PMID:22529213  
PMID:22554776   PMID:22613711   PMID:22615852   PMID:22617488   PMID:22697788   PMID:22699075   PMID:22706317   PMID:22710061   PMID:22715380   PMID:22743055   PMID:22795792   PMID:22796213  
PMID:22822059   PMID:22836011   PMID:22869351   PMID:22932066   PMID:22941198   PMID:22981168   PMID:23000030   PMID:23017227   PMID:23034271   PMID:23076999   PMID:23077050   PMID:23123184  
PMID:23318465   PMID:23326018   PMID:23376588   PMID:23398888   PMID:23426662   PMID:23510989   PMID:23520364   PMID:23537341   PMID:23648475   PMID:23665321   PMID:23681983   PMID:23695883  
PMID:23747799   PMID:23766263   PMID:23817958   PMID:23828564   PMID:23892723   PMID:23928073   PMID:24003233   PMID:24020812   PMID:24037056   PMID:24048027   PMID:24095834   PMID:24114903  
PMID:24129485   PMID:24144795   PMID:24152426   PMID:24157594   PMID:24216329   PMID:24234155   PMID:24252536   PMID:24338227   PMID:24338258   PMID:24376764   PMID:24425765   PMID:24432310  
PMID:24498101   PMID:24571083   PMID:24621600   PMID:24677092   PMID:24771421   PMID:24784232   PMID:24917666   PMID:24955935   PMID:24965599   PMID:25024200   PMID:25070591   PMID:25081109  
PMID:25108165   PMID:25120739   PMID:25204733   PMID:25327529   PMID:25430780   PMID:25453765   PMID:25455591   PMID:25466829   PMID:25476526   PMID:25480578   PMID:25511383   PMID:25617163  
PMID:25697011   PMID:25702530   PMID:25801039   PMID:25816133   PMID:25847140   PMID:25863030   PMID:25931416   PMID:25979559   PMID:26055433   PMID:26084225   PMID:26203149   PMID:26239160  
PMID:26279426   PMID:26279447   PMID:26304161   PMID:26306596   PMID:26308798   PMID:26344001   PMID:26394923   PMID:26403276   PMID:26591203   PMID:26678483   PMID:26687115   PMID:26818462  
PMID:26827495   PMID:26858253   PMID:26881256   PMID:26884383   PMID:26902320   PMID:26909757   PMID:26923576   PMID:26927380   PMID:26987229   PMID:27038016   PMID:27104804   PMID:27175012  
PMID:27178341   PMID:27188585   PMID:27214337   PMID:27235543   PMID:27363337   PMID:27412645   PMID:27424133   PMID:27744091   PMID:27764704   PMID:27767056   PMID:28005965   PMID:28153540  
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PMID:35389569   PMID:35851539   PMID:35883093   PMID:37749991   PMID:37838078   PMID:38194074   PMID:39182540  


Genomics

Comparative Map Data
Il1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83137,030,200 - 137,036,581 (-)NCBIGRCr8
mRatBN7.23116,577,005 - 116,583,386 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3116,577,010 - 116,583,415 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3120,474,110 - 120,480,521 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03129,069,733 - 129,076,144 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03126,730,207 - 126,736,618 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03121,876,256 - 121,882,637 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3121,876,263 - 121,882,726 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03128,133,929 - 128,140,354 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43116,964,422 - 116,970,867 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13116,869,999 - 116,876,460 (-)NCBI
Celera3115,403,045 - 115,409,735 (-)NCBICelera
RH 3.4 Map31000.1RGD
Cytogenetic Map3q36NCBI
IL1B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382112,829,751 - 112,836,779 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2112,829,751 - 112,836,816 (-)EnsemblGRCh38hg38GRCh38
GRCh372113,587,328 - 113,594,356 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362113,303,808 - 113,310,827 (-)NCBINCBI36Build 36hg18NCBI36
Build 342113,303,567 - 113,310,587NCBI
Celera2106,972,536 - 106,979,555 (-)NCBICelera
Cytogenetic Map2q14.1NCBI
HuRef2106,041,964 - 106,048,983 (-)NCBIHuRef
CHM1_12113,591,491 - 113,598,510 (-)NCBICHM1_1
T2T-CHM13v2.02113,256,242 - 113,263,270 (-)NCBIT2T-CHM13v2.0
Il1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392129,206,490 - 129,213,059 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2129,206,490 - 129,213,059 (-)EnsemblGRCm39 Ensembl
GRCm382129,364,569 - 129,371,164 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2129,364,570 - 129,371,139 (-)EnsemblGRCm38mm10GRCm38
MGSCv372129,190,315 - 129,196,856 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362129,056,020 - 129,062,561 (-)NCBIMGSCv36mm8
Celera2130,592,096 - 130,598,637 (-)NCBICelera
Cytogenetic Map2F1NCBI
cM Map262.97NCBI
Il1b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554701,486,967 - 1,491,947 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554701,486,936 - 1,491,888 (+)NCBIChiLan1.0ChiLan1.0
IL1B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21215,277,345 - 15,288,509 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A15,284,243 - 15,291,284 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A89,216,313 - 89,223,358 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A113,846,299 - 113,853,424 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A113,846,306 - 113,853,424 (-)Ensemblpanpan1.1panPan2
IL1B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11737,019,329 - 37,033,388 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1737,019,329 - 37,024,458 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1736,788,618 - 36,793,136 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01737,794,784 - 37,800,390 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1737,795,225 - 37,800,354 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11736,930,880 - 36,935,397 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01736,987,147 - 36,991,665 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01737,201,034 - 37,205,552 (-)NCBIUU_Cfam_GSD_1.0
Il1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629282,357,182 - 82,363,416 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367831,252,158 - 1,257,165 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367831,251,678 - 1,256,807 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC110258578
(Sus scrofa - pig)		 No map positions available.
IL1B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11415,844,628 - 15,852,652 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1415,844,672 - 15,850,729 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660803,810,298 - 3,839,365 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il1b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474912,852,021 - 12,858,760 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474912,852,128 - 12,858,478 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Il1b
31 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:64
Count of miRNA genes:57
Interacting mature miRNAs:64
Transcripts:ENSRNOT00000006308
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)370653097121056321Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat
7387306Bw124Body weight QTL 1243.20.0003body mass (VT:0001259)body weight (CMO:0000012)384091273129091273Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)373376539118376539Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)391797474136797474Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)397084464142084464Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)389772419134772419Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
1358204Insglur1Insulin/glucose ratio QTL 13.8blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)3115638168135181505Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3107693393152693393Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)370348525121056321Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
1331758Bp207Blood pressure QTL 2072.848arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3112287552135181505Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)395735366140735366Rat

Markers in Region
PMC22755P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23116,577,542 - 116,578,515 (+)MAPPERmRatBN7.2
Rnor_6.03121,876,794 - 121,877,766NCBIRnor6.0
Rnor_5.03128,138,844 - 128,139,816UniSTSRnor5.0
RGSC_v3.43116,964,960 - 116,965,932UniSTSRGSC3.4
Celera3115,403,583 - 115,404,555UniSTS
Cytogenetic Map3q36UniSTS
RH142428  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23116,579,747 - 116,580,480 (+)MAPPERmRatBN7.2
Rnor_6.03121,878,999 - 121,879,731NCBIRnor6.0
Rnor_5.03128,136,835 - 128,137,567UniSTSRnor5.0
RGSC_v3.43116,967,229 - 116,967,961UniSTSRGSC3.4
Celera3115,406,097 - 115,406,829UniSTS
RH 3.4 Map31000.1UniSTS
Cytogenetic Map3q36UniSTS
PMC151130P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23116,577,544 - 116,578,516 (+)MAPPERmRatBN7.2
Rnor_6.03121,876,796 - 121,877,767NCBIRnor6.0
Rnor_5.03128,138,843 - 128,139,814UniSTSRnor5.0
RGSC_v3.43116,964,962 - 116,965,933UniSTSRGSC3.4
Celera3115,403,585 - 115,404,556UniSTS
Cytogenetic Map3q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 45 91 91 90 59 25 59 6 213 93 71 44 55 31

Sequence


Ensembl Acc Id: ENSRNOT00000006308   ⟹   ENSRNOP00000006308
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3116,577,010 - 116,583,406 (-)Ensembl
Rnor_6.0 Ensembl3121,876,263 - 121,882,726 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000116269   ⟹   ENSRNOP00000088822
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3116,577,010 - 116,583,415 (-)Ensembl
RefSeq Acc Id: NM_031512   ⟹   NP_113700
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83137,030,200 - 137,036,581 (-)NCBI
mRatBN7.23116,577,005 - 116,583,386 (-)NCBI
Rnor_6.03121,876,256 - 121,882,637 (-)NCBI
Rnor_5.03128,133,929 - 128,140,354 (+)NCBI
RGSC_v3.43116,964,422 - 116,970,867 (-)RGD
Celera3115,403,045 - 115,409,735 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_113700 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41426 (Get FASTA)   NCBI Sequence Viewer  
  AAH91141 (Get FASTA)   NCBI Sequence Viewer  
  EDL80163 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000006308.2
  ENSRNOP00000088822.1
GenBank Protein Q63264 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_113700   ⟸   NM_031512
- UniProtKB: Q63264 (UniProtKB/Swiss-Prot),   Q5BKB0 (UniProtKB/TrEMBL),   F7F755 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000006308   ⟸   ENSRNOT00000006308
Ensembl Acc Id: ENSRNOP00000088822   ⟸   ENSRNOT00000116269
Protein Domains
Interleukin-1 propeptide

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63264-F1-model_v2 AlphaFold Q63264 1-268 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692423
Promoter ID:EPDNEW_R2948
Type:single initiation site
Name:Il1b_1
Description:interleukin 1 beta
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03121,882,667 - 121,882,727EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2891 AgrOrtholog
BioCyc Gene G2FUF-47908 BioCyc
Ensembl Genes ENSRNOG00000004649 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000006308.5 UniProtKB/TrEMBL
  ENSRNOT00000116269.1 UniProtKB/TrEMBL
Gene3D-CATH 2.80.10.50 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7365029 IMAGE-MGC_LOAD
InterPro IL-1_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-1_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-1_propep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL1/FGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24494 UniProtKB/TrEMBL
MGC_CLONE MGC:108658 IMAGE-MGC_LOAD
NCBI Gene 24494 ENTREZGENE
PANTHER PTHR10078 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10078:SF30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam IL1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL1_propep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB IL1B RGD
PhenoGen Il1b PhenoGen
PRINTS IL1HBGF UniProtKB/TrEMBL
  INTERLEUKIN1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  INTRLEUKIN1B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  INTRLEUKN1AB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE INTERLEUKIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004649 RatGTEx
SMART IL1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50353 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A5V4_RAT UniProtKB/TrEMBL
  F7F755 ENTREZGENE, UniProtKB/TrEMBL
  IL1B_RAT UniProtKB/Swiss-Prot
  Q5BKB0 ENTREZGENE, UniProtKB/TrEMBL
  Q63264 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Il1b  Interleukin 1 beta      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease neurotoxin, N-(2-chloroethyl)-N-ethyl-2 bromobenzylamine (DSP4) induces chemical lesions in the locus ceruleus neurons which is a feature of Alzheimers disease 625673
gene_expression maximum level of mRNA is expressed in microglia 1 day after amyloid beta injection and the level reduces after days 3 and 7 625673
gene_process induces nerve growth factor (NGF) mRNA in cultured fibroblasts and acts synergistically with tumor necrosis factor (TNF) to increase NGF mRNA from cultured astrocytes 625630
gene_process may regulate amyloid precursor protein (APP)expression after traumatic brain injury 727500
gene_regulation mRNA level dramatically increases after cyclophosphamide (CYP)-induced cystitis 625673