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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2891
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il1b
Name: interleukin 1 beta
Acc ID: CHEBI:4317
Term: dantrolene
Definition: The hydrazone resulting from the formal condensation of 5-(4-nitrophenyl)furfural with 1-aminohydantoin. A ryanodine receptor antagonist used for the relief of chronic severe spasticity and malignant hyperthermia.
Chemical ID: MESH:D003620
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il1baffects expressionEXP 6480464CTDDantrolene affects the expression of IL1B mRNAPMID:25051504
Il1bmultiple interactionsISOIl1b (Mus musculus)6480464CTDDantrolene inhibits the reaction [Halothane results in increased expression of IL1B mRNA]PMID:32795494
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