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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2891
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il1b
Name: interleukin 1 beta
Acc ID: CHEBI:35696
Term: cobalt dichloride
Definition: A cobalt salt in which the cobalt metal is in the +2 oxidation state and the counter-anion is chloride. It is used as an indicator for water in desiccants.
Chemical ID: MESH:C018021
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il1bincreases expressionEXP 6480464CTDcobaltous chloride results in increased expression of IL1B proteinPMID:21296072 PMID:31362009
Il1bmultiple interactionsEXP 6480464CTDcobaltous chloride inhibits the reaction [Oxygen deficiency results in increased expression of IL1B protein]; Gallic Acid inhibits the reaction [cobaltous chloride results in increased expression of IL1B protein]; Luteolin inhibits the reaction [cobaltous chloride results in increased expression of IL1B protein]PMID:18635243 PMID:21296072 PMID:31362009
Il1bdecreases expressionISOIL1B (Homo sapiens)6480464CTDcobaltous chloride results in decreased expression of IL1B mRNAPMID:29594315
Il1bincreases expressionISOIl1b (Mus musculus)6480464CTDcobaltous chloride results in increased expression of IL1B mRNAPMID:16504308
Il1bincreases expressionISOIL1B (Homo sapiens)6480464CTDcobaltous chloride results in increased expression of IL1B mRNA; cobaltous chloride results in increased expression of IL1B proteinPMID:16504308 PMID:20974702
Il1bincreases secretionISOIl1b (Mus musculus)6480464CTDcobaltous chloride results in increased secretion of IL1B proteinPMID:19844976
Il1bincreases secretionISOIL1B (Homo sapiens)6480464CTDcobaltous chloride results in increased secretion of IL1B proteinPMID:21779360
Il1bmultiple interactionsISOIl1b (Mus musculus)6480464CTD2,2-bis(4-glycidyloxyphenyl)propane affects the reaction [[cobaltous chloride co-treated with lipopolysaccharide, E coli O55-B5 co-treated with Phloretin] results in increased expression of IL1B mRNA]; 2,2-bis(4-glycidyloxyphenyl)propane affects the reaction [[cobaltous chloride co-treated with Phloretin] affects the expression of IL1B mRNA]; 2,2-bis(4-glycidyloxyphenyl)propane affects the reaction [[cobaltous chloride co-treated with Phlorhizin] affects the expression of IL1B mRNA]; [cobaltous chloride co-treated with lipopolysaccharide, E coli O55-B5 co-treated with Phloretin] results in increased expression of IL1B mRNA; [cobaltous chloride co-treated with Phloretin] affects the expression of IL1B mRNA; [cobaltous chloride co-treated with Phlorhizin] affects the expression of IL1B mRNA; cobaltous chloride promotes the reaction [[HIF1A protein binds to IL1B promoter] which results in increased expression of IL1B mRNA]PMID:16504308 PMID:32408695
Il1bmultiple interactionsISOIL1B (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [cobaltous chloride results in increased secretion of IL1B protein]; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [cobaltous chloride results in increased secretion of IL1B protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [cobaltous chloride results in increased secretion of IL1B protein]; sodium bisulfide inhibits the reaction [cobaltous chloride results in increased secretion of IL1B protein]PMID:21779360
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