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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2891
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il1b
Name: interleukin 1 beta
Acc ID: CHEBI:6682
Term: mangiferin
Definition: A C-glycosyl compound consisting of 1,3,6,7-tetrahydroxyxanthen-9-one having a beta-D-glucosyl residue at the 6-position.
Chemical ID: MESH:C013592
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il1bmultiple interactionsEXP 6480464CTDmangiferin inhibits the reaction [Galactosamine results in increased expression of IL1B mRNA]; mangiferin inhibits the reaction [IL1B protein results in increased expression of NOS2 mRNA]; mangiferin inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]; mangiferin inhibits the reaction [Methotrexate results in increased expression of IL1B protein]PMID:15381052 PMID:22310181 PMID:36249937
Il1bmultiple interactionsISOIl1b (Mus musculus)6480464CTDmangiferin analog inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL1B protein]; mangiferin inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]PMID:27125760 PMID:27474068
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