RGD Reference Report - Retinal cytokine response in mouse alkali-burned eye. - Rat Genome Database

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Retinal cytokine response in mouse alkali-burned eye.

Authors: Miyamoto, F  Sotozono, C  Ikeda, T  Kinoshita, S 
Citation: Miyamoto F, etal., Ophthalmic Res. 1998;30(3):168-71.
RGD ID: 7794723
Pubmed: PMID:9618720   (View Abstract at PubMed)

The kinetics of inflammatory cytokines in sensory retina of mice with corneal alkali-burned eyes were examined. Retinal samples were collected from ICR mice with unburned and alkali-burned eyes from day 3 to day 14. Enzyme-linked immunosorbent assay was used to quantitate the expression levels of interleukin-1 alpha (IL-1 alpha), IL-1 beta and IL-6. Concentrations of IL-1 beta and IL-6 were significantly elevated at day 3 after alkali burn, and reduced to normal level by day 7. The concentration of IL-1 alpha was below assay sensitivity at all times. A significant elevation of IL-1 beta and IL-6 in the sensory retina may contribute to the retinal inflammatory response in the alkali-burned eyes. This is the first report suggesting that the retina is involved in the damage process of alkali burn.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Eye Burns  ISOIl1b (Mus musculus)7794723; 7794723protein:increased expression:retinaRGD 
Eye Burns  IEP 7794723protein:increased expression:retinaRGD 

Objects Annotated

Genes (Rattus norvegicus)
Il1b  (interleukin 1 beta)

Genes (Mus musculus)
Il1b  (interleukin 1 beta)

Genes (Homo sapiens)
IL1B  (interleukin 1 beta)


Additional Information