RGD Reference Report - The cyclooxygenase-2 inhibitor parecoxib inhibits surgery-induced proinflammatory cytokine expression in the hippocampus in aged rats. - Rat Genome Database

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The cyclooxygenase-2 inhibitor parecoxib inhibits surgery-induced proinflammatory cytokine expression in the hippocampus in aged rats.

Authors: Peng, M  Wang, YL  Wang, FF  Chen, C  Wang, CY 
Citation: Peng M, etal., J Surg Res. 2012 Nov;178(1):e1-8. doi: 10.1016/j.jss.2012.08.030. Epub 2012 Aug 31.
RGD ID: 7204702
Pubmed: PMID:22959208   (View Abstract at PubMed)
DOI: DOI:10.1016/j.jss.2012.08.030   (Journal Full-text)

BACKGROUND: Neuroinflammatory response triggered by surgery has been increasingly reported to be associated with postoperative cognitive dysfunction. Proinflammatory cytokines, such as interleukin 1beta (IL-1beta) and tumor necrosis factor alpha (TNF-alpha), play a pivotal role in mediating surgery-induced neuroinflammation. The role of cyclooxygenase-2 (COX-2), a critical regulator in inflammatory response, in surgery-induced neuroinflammation is still unknown. The aim of the study was to investigate the changes of COX-2 expression and prostaglandin E2 (PGE2) production in the hippocampus in aged rats following partial hepatectomy. The effects of selective COX-2 inhibitor (parecoxib) on hippocampal proinflammatory cytokine expression were also evaluated. METHODS: Aged rats were randomly divided into three groups: control (n = 10), surgery (n = 30), and parecoxib (n = 30). Control animals received sterile saline to control for the effects of injection stress. Rats in the surgery group received partial hepatectomy under isoflurane anesthesia and sterile saline injection. Rats in the parecoxib group received surgery and anesthesia similar to surgery group rats, and parecoxib treatment. On postanesthetic days 1, 3, and 7, animals were euthanized to assess levels of hippocampal COX-2 expression, PGE2 production, and cytokines IL-1beta and TNF-alpha expression. The effects of parecoxib on proinflammatory cytokine expression were also assessed. RESULTS: Partial hepatectomy significantly increased COX-2 expression, PGE2 production, and proinflammatory cytokine expression in the hippocampus in aged rats on postoperative days 1 and 3. Parecoxib inhibited hippocampal IL-1beta and TNF-alpha expression through downregulation of the COX-2/PGE2 pathway. CONCLUSION: COX-2 may play a critical role in surgery-induced neuroinflammation. The COX-2 inhibitor may be a promising candidate for treatment of neuroinflammation caused by surgical trauma.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Postoperative Cognitive Dysfunction  ISOIl1b (Rattus norvegicus)7204702; 7204702 RGD 
Postoperative Cognitive Dysfunction  IDA 7204702 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Il1b  (interleukin 1 beta)

Genes (Mus musculus)
Il1b  (interleukin 1 beta)

Genes (Homo sapiens)
IL1B  (interleukin 1 beta)


Additional Information