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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2891
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il1b
Name: interleukin 1 beta
Acc ID: CHEBI:4903
Term: 17alpha-ethynylestradiol
Definition: A 3-hydroxy steroid that is estradiol substituted by a ethynyl group at position 17. It is a xenoestrogen synthesized from estradiol and has been shown to exhibit high estrogenic potency on oral administration.
Chemical ID: MESH:D004997
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il1bincreases expressionEXP 6480464CTDEthinyl Estradiol results in increased expression of IL1B mRNA; Ethinyl Estradiol results in increased expression of IL1B proteinPMID:25051504
Il1baffects expressionISOIl1b (Mus musculus)6480464CTDEthinyl Estradiol affects the expression of IL1B mRNAPMID:15885639
Il1bincreases expressionISOIl1b (Mus musculus)6480464CTDEthinyl Estradiol results in increased expression of IL1B mRNAPMID:17942748
Il1bmultiple interactionsISOIl1b (Mus musculus)6480464CTD[Ethinyl Estradiol co-treated with ESR1 protein] inhibits the reaction [IL1B protein results in increased expression of BCL3 mRNA]; [Ethinyl Estradiol co-treated with ESR1 protein] inhibits the reaction [IL1B protein results in increased expression of CISH mRNA]; [Ethinyl Estradiol co-treated with ESR1 protein] inhibits the reaction [IL1B protein results in increased expression of CXCL5 mRNA]; [Ethinyl Estradiol co-treated with ESR1 protein] inhibits the reaction [IL1B protein results in increased expression of NR0B2 mRNA]; [Ethinyl Estradiol co-treated with ESR1 protein] inhibits the reaction [IL1B protein results in increased expression of PLK3 mRNA]; [Ethinyl Estradiol co-treated with IL1B protein] results in increased expression of APOA4 mRNA; [Ethinyl Estradiol co-treated with IL1B protein] results in increased expression of C1QB mRNA; [Ethinyl Estradiol co-treated with IL1B protein] results in increased expression of PTGDS mRNA; [Ethinyl Estradiol co-treated with IL1B protein] results in increased expression of TFF3 mRNA; [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of IL1B mRNA; Ethinyl Estradiol inhibits the reaction [IL1B protein results in increased expression of BCL3 mRNA]; Ethinyl Estradiol inhibits the reaction [IL1B protein results in increased expression of BIRC3 mRNA]; Ethinyl Estradiol inhibits the reaction [IL1B protein results in increased expression of CD83 mRNA]; Ethinyl Estradiol inhibits the reaction [IL1B protein results in increased expression of CISH mRNA]; Ethinyl Estradiol inhibits the reaction [IL1B protein results in increased expression of CXCL5 mRNA]; Ethinyl Estradiol inhibits the reaction [IL1B protein results in increased expression of CXCL9 mRNA]; Ethinyl Estradiol inhibits the reaction [IL1B protein results in increased expression of ELF3 mRNA]; Ethinyl Estradiol inhibits the reaction [IL1B protein results in increased expression of GADD45A mRNA]; Ethinyl Estradiol inhibits the reaction [IL1B protein results in increased expression of GADD45B mRNA]; Ethinyl Estradiol inhibits the reaction [IL1B protein results in increased expression of GBP2 mRNA]; Ethinyl Estradiol inhibits the reaction [IL1B protein results in increased expression of H2-L mRNA]; Ethinyl Estradiol inhibits the reaction [IL1B protein results in increased expression of HMOX1 mRNA]; Ethinyl Estradiol inhibits the reaction [IL1B protein results in increased expression of HSPA1A mRNA]; Ethinyl Estradiol inhibits the reaction [IL1B protein results in increased expression of ID3 mRNA]; Ethinyl Estradiol inhibits the reaction [IL1B protein results in increased expression of IFI47 mRNA]; Ethinyl Estradiol inhibits the reaction [IL1B protein results in increased expression of IL15RA mRNA]; Ethinyl Estradiol inhibits the reaction [IL1B protein results in increased expression of LCN2 mRNA]; Ethinyl Estradiol inhibits the reaction [IL1B protein results in increased expression of NFKB1 mRNA]; Ethinyl Estradiol inhibits the reaction [IL1B protein results in increased expression of PLK3 mRNA]; Ethinyl Estradiol inhibits the reaction [IL1B protein results in increased expression of RHOB mRNA]; Ethinyl Estradiol inhibits the reaction [IL1B protein results in increased expression of SOCS3 mRNA]; Ethinyl Estradiol inhibits the reaction [IL1B protein results in increased expression of TGTP1 mRNA]; Ethinyl Estradiol promotes the reaction [IL1B protein results in increased expression of CD14 mRNA]; Ethinyl Estradiol promotes the reaction [IL1B protein results in increased expression of CXCL2 mRNA]; Ethinyl Estradiol promotes the reaction [IL1B protein results in increased expression of NFE2L2 mRNA]; Ethinyl Estradiol promotes the reaction [IL1B protein results in increased expression of S100A9 mRNA]; Ethinyl Estradiol promotes the reaction [IL1B protein results in increased expression of SLC20A1 mRNA]; Ethinyl Estradiol promotes the reaction [IL1B protein results in increased expression of VCAM1 mRNA]PMID:12072388 PMID:17942748
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