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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2891
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il1b
Name: interleukin 1 beta
Acc ID: CHEBI:15355
Term: acetylcholine
Definition: Actylcholine is an ester of acetic acid and choline, which acts as a neurotransmitter.
Chemical ID: MESH:D000109
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il1bincreases secretionISOIl1b (Mus musculus)6480464CTDIL1B protein results in increased secretion of AcetylcholinePMID:16122837
Il1bmultiple interactionsISOIl1b (Mus musculus)6480464CTD[IL1B protein co-treated with APP protein] results in increased secretion of Acetylcholine; IL1B protein inhibits the reaction [APP protein results in decreased secretion of Acetylcholine]PMID:16122837
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