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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2891
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il1b
Name: interleukin 1 beta
Acc ID: CHEBI:2955
Term: azithromycin
Definition: A macrolide antibiotic useful for the treatment of bacterial infections.
Chemical ID: MESH:D017963
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il1bdecreases expressionISOIl1b (Mus musculus)6480464CTDAzithromycin results in decreased expression of IL1B proteinPMID:18435685
Il1bmultiple interactionsISOIl1b (Mus musculus)6480464CTDAzithromycin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; Azithromycin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]PMID:21195124
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