RGD Reference Report - Interleukin-1 beta, interleukin-1 receptor antagonist and interleukin-6 plasma levels and cytokine gene polymorphisms in chronic lymphocytic leukemia: correlation with prognostic parameters. - Rat Genome Database

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Interleukin-1 beta, interleukin-1 receptor antagonist and interleukin-6 plasma levels and cytokine gene polymorphisms in chronic lymphocytic leukemia: correlation with prognostic parameters.

Authors: Hulkkonen, J  Vilpo, J  Vilpo, L  Koski, T  Hurme, M 
Citation: Hulkkonen J, etal., Haematologica. 2000 Jun;85(6):600-6.
RGD ID: 11522755
Pubmed: PMID:10870116   (View Abstract at PubMed)

BACKGROUND AND OBJECTIVE: The growth of B-cell chronic lymphocytic leukemia (B-CLL) cells has been shown to be dependent on exogenous growth factors in vitro. We wanted to evaluate the clinical relevance of interleukin (IL)-6, IL-1 beta and interleukin-1 receptor antagonist (IL-1Ra) in B-CLL. As the plasma levels of IL-6, IL-1 beta and IL-1Ra have been suggested to be partly dependent on gene polymorphism, the previously described polymorphisms of the IL-1 complex genes and the IL-6 gene were also studied. DESIGN AND METHODS: The plasma levels of these cytokines were measured in a cohort of 36 patients with B-CLL and in 400 healthy subjects. The previously described polymorphisms of the IL-1 complex genes and the IL-6 gene were studied using PCR and RFLP. These data was correlated with other parameters associated with severity and prognosis of B-CLL and a number of clinical and laboratory findings. RESULTS: The plasma concentrations of IL-1 beta and IL-1Ra were lower in B-CLL patients than in normal controls (p < 0.001). The IL-1 beta plasma levels were dependent on the cell immunophenotype score and state of progression of the disease. Moreover, plasma concentrations of IL-6 were elevated in B-CLL patients compared with healthy subjects (p < 0.005) and correlated with disease stage, hemoglobin levels, anemia and erythrocyte sedimentation rate in the patients. The allele frequencies of the analyzed genes were similar in patients and controls. INTERPRETATION AND CONCLUSIONS: Our data demonstrate that in B-CLL, plasma levels of IL-1 beta, IL-1Ra and IL-6 differ from normal, and mechanisms other than allelic imbalance of their genes account for the distinct cytokine profiles observed in this disease.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
B-Cell Chronic Lymphocytic Leukemia severityIEP 11522755protein:decreased expression:plasma:RGD 
B-Cell Chronic Lymphocytic Leukemia  IEP 11522755protein:decreased expression:plasma:RGD 
B-Cell Chronic Lymphocytic Leukemia  IEP 11522755protein:increased expression:plasma:RGD 
B-Cell Chronic Lymphocytic Leukemia severityISOIL1B (Homo sapiens)11522755; 11522755protein:decreased expression:plasma:RGD 
B-Cell Chronic Lymphocytic Leukemia  ISOIL1RN (Homo sapiens)11522755; 11522755protein:decreased expression:plasma:RGD 
B-Cell Chronic Lymphocytic Leukemia  ISOIL6 (Homo sapiens)11522755; 11522755protein:increased expression:plasma:RGD 

Objects Annotated

Genes (Rattus norvegicus)
Il1b  (interleukin 1 beta)
Il1rn  (interleukin 1 receptor antagonist)
Il6  (interleukin 6)

Genes (Mus musculus)
Il1b  (interleukin 1 beta)
Il1rn  (interleukin 1 receptor antagonist)
Il6  (interleukin 6)

Genes (Homo sapiens)
IL1B  (interleukin 1 beta)
IL1RN  (interleukin 1 receptor antagonist)
IL6  (interleukin 6)


Additional Information